Chlorhexidine (diacetate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Chlorhexidine (diacetate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Chlorhexidine (diacetate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.151563
MYH9 myosin, heavy chain 9, non-muscle 0.140922
COL6A3 collagen, type VI, alpha 3 0.134955
MYO10 myosin X 0.108793
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.103465
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0948934
B2M beta-2-microglobulin 0.0907094
HLA-B major histocompatibility complex, class I, B 0.0790675
INHBA inhibin, beta A 0.0728933
NDRG1 N-myc downstream regulated 1 0.07148
DST dystonin 0.0702901
CD44 CD44 molecule (Indian blood group) 0.0597489
RPS12 ribosomal protein S12 0.0535253
TIMP1 TIMP metallopeptidase inhibitor 1 0.0533924
FAM13A family with sequence similarity 13, member A 0.0519875
HIPK2 homeodomain interacting protein kinase 2 0.0516387
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0504401
STC1 stanniocalcin 1 0.0504058
CLMP CXADR-like membrane protein 0.049823
AKAP12 A kinase (PRKA) anchor protein 12 0.0486121
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0480277
ATP13A3 ATPase type 13A3 0.0453886
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0446536
ARHGAP21 Rho GTPase activating protein 21 0.0442161
HLA-A major histocompatibility complex, class I, A 0.044113
NAMPT nicotinamide phosphoribosyltransferase 0.0438722
TGFBI transforming growth factor, beta-induced, 68kDa 0.0430762
FMNL2 formin-like 2 0.0428575
ARHGAP22 Rho GTPase activating protein 22 0.0409819
CD59 CD59 molecule, complement regulatory protein 0.0409684
PRRC2C proline-rich coiled-coil 2C 0.0405457
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0404981
RPL35A ribosomal protein L35a 0.0390999
SPAG9 sperm associated antigen 9 0.0387493
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0350296
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0347026
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0337815
CALR calreticulin 0.0336409
IGFBP7 insulin-like growth factor binding protein 7 0.0336291
MCL1 myeloid cell leukemia 1 0.0329051
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0320636
JARID2 jumonji, AT rich interactive domain 2 0.0317489
RPL37A ribosomal protein L37a 0.031658
ZEB1 zinc finger E-box binding homeobox 1 0.0312911
IGF2 insulin-like growth factor 2 0.0311013
MEIS1 Meis homeobox 1 0.0307818
PDE8A phosphodiesterase 8A 0.0298925
SRRM2 serine/arginine repetitive matrix 2 0.0289064
UBA6 ubiquitin-like modifier activating enzyme 6 0.028891
MSN moesin 0.0281327
TPT1 tumor protein, translationally-controlled 1 0.0279687
RPL11 ribosomal protein L11 0.0279054
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0278656
RASA2 RAS p21 protein activator 2 0.0277634
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0276107
ITPRID2 ITPR interacting domain containing 2 0.0274655
STC2 stanniocalcin 2 0.0273961
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0271779
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0263743
SOD2 superoxide dismutase 2, mitochondrial 0.0262959
RAB6A RAB6A, member RAS oncogene family 0.0260713
VEGFA vascular endothelial growth factor A 0.0260203
HMGA2 high mobility group AT-hook 2 0.0247966
S100A9 S100 calcium binding protein A9 0.0240958
TPM3 tropomyosin 3 0.0239765
GANAB glucosidase, alpha; neutral AB 0.0238333
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0238264
RPS3 ribosomal protein S3 0.0237823
TBX2 T-box 2 0.0237457
ITGA11 integrin, alpha 11 0.0232782
SET SET nuclear proto-oncogene 0.0230108
PALM2AKAP2 PALM2 and AKAP2 fusion 0.022738
RPL23 ribosomal protein L23 0.0225424
ANXA5 annexin A5 0.0224834
ANGPTL4 angiopoietin-like 4 0.0223229
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0222077
NBAS neuroblastoma amplified sequence 0.0221768
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0219723
SPRED1 sprouty-related, EVH1 domain containing 1 0.0219439
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0217975
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.021658
DNER delta/notch-like EGF repeat containing 0.0215415
GIGYF2 GRB10 interacting GYF protein 2 0.0214867
MRC2 mannose receptor, C type 2 0.0213414
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0213304
RAB8B RAB8B, member RAS oncogene family 0.021194
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0211435
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0209035
ARRDC3 arrestin domain containing 3 0.0208686
CEMIP cell migration inducing protein, hyaluronan binding 0.0208082
SMOX spermine oxidase 0.0207176
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.020706
NUP58 nucleoporin 58 0.0206718
PLAUR plasminogen activator, urokinase receptor 0.0206337
RPL3 ribosomal protein L3 0.0206324
SFTPA2 surfactant protein A2 0.0205071
COL6A1 collagen, type VI, alpha 1 0.0202808
NCKAP1 NCK-associated protein 1 0.020238
MMP1 matrix metallopeptidase 1 0.0201629
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0201454

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.32927
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.193594
VIM vimentin -0.18889
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0947135
AHNAK AHNAK nucleoprotein -0.090825
EMP1 epithelial membrane protein 1 -0.0878101
FNDC3B fibronectin type III domain containing 3B -0.0811792
ACTG1 actin gamma 1 -0.0686882
ABI3BP ABI family, member 3 (NESH) binding protein -0.0658599
VCL vinculin -0.05968
LMAN1 lectin, mannose-binding, 1 -0.0595371
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0587305
ASPH aspartate beta-hydroxylase -0.0571029
HDLBP high density lipoprotein binding protein -0.0561458
RRBP1 ribosome binding protein 1 -0.0543944
LOC112694756 uncharaterized LOC112694756 -0.0524033
ADGRB3 adhesion G protein-coupled receptor B3 -0.0522493
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.050032
FN1 fibronectin 1 -0.0484418
PRKG1 protein kinase, cGMP-dependent, type I -0.0456434
COL1A2 collagen, type I, alpha 2 -0.0440078
COL1A1 collagen, type I, alpha 1 -0.0404736
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0404329
CAVIN1 caveolae associated protein 1 -0.039587
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0389642
INTS6 integrator complex subunit 6 -0.0384386
FBN1 fibrillin 1 -0.0380498
CALD1 caldesmon 1 -0.0375574
PKM pyruvate kinase, muscle -0.0365239
LOX lysyl oxidase -0.0364683
SEC24D SEC24 family member D -0.0345155
INSIG1 insulin induced gene 1 -0.0337868
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0319344
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0317835
IER3 immediate early response 3 -0.0317308
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0311401
NABP1 nucleic acid binding protein 1 -0.0290814
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0290536
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0287821
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0286642
BZW1 basic leucine zipper and W2 domains 1 -0.0285864
CAV1 caveolin 1, caveolae protein, 22kDa -0.0282747
CALU calumenin -0.0281293
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0275896
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0272496
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0269153
FTH1 ferritin, heavy polypeptide 1 -0.0263125
RPL4 ribosomal protein L4 -0.0261921
RPS24 ribosomal protein S24 -0.0260579
TPM4 tropomyosin 4 -0.026029
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0260187
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.025841
TUBB tubulin, beta class I -0.0258
CANX calnexin -0.0257798
CCDC102B coiled-coil domain containing 102B -0.0255981
TRAM1 translocation associated membrane protein 1 -0.0253669
TMEM263 transmembrane protein 263 -0.0252057
MAP1B microtubule-associated protein 1B -0.0251679
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0247591
SQSTM1 sequestosome 1 -0.0247457
GARS1 glycyl-tRNA synthetase 1 -0.0247115
DIAPH2 diaphanous-related formin 2 -0.0243194
FTL ferritin, light polypeptide -0.0242443
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0237362
PDLIM5 PDZ and LIM domain 5 -0.0236999
GNAS GNAS complex locus -0.0232521
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0232384
NBEAL1 neurobeachin-like 1 -0.0229281
FUS FUS RNA binding protein -0.0226358
NID2 nidogen 2 (osteonidogen) -0.0225765
EPAS1 endothelial PAS domain protein 1 -0.0223156
ANXA2 annexin A2 -0.0221682
POTEF POTE ankyrin domain family, member F -0.0219951
VDAC1 voltage-dependent anion channel 1 -0.02183
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0216762
BTG1 B-cell translocation gene 1, anti-proliferative -0.0215976
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0214841
PTMA prothymosin, alpha -0.0213224
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0211103
MAML2 mastermind-like 2 (Drosophila) -0.0210524
LOXL2 lysyl oxidase-like 2 -0.0209754
PGK1 phosphoglycerate kinase 1 -0.0207958
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0207035
GLG1 golgi glycoprotein 1 -0.0205886
IPO9 importin 9 -0.0205407
SLIT2 slit homolog 2 (Drosophila) -0.020425
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.02019
ZBTB20 zinc finger and BTB domain containing 20 -0.0200625
ACLY ATP citrate lyase -0.0199324
PALLD palladin, cytoskeletal associated protein -0.0199191
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0196855
BBS9 Bardet-Biedl syndrome 9 -0.0193804
SLC38A2 solute carrier family 38, member 2 -0.0185754
PARVA parvin, alpha -0.0185063
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0184229
OSMR oncostatin M receptor -0.0183747
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0183427
CLIC4 chloride intracellular channel 4 -0.0181969
TPM1 tropomyosin 1 (alpha) -0.0181782
HOOK3 hook microtubule-tethering protein 3 -0.0181179