| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/439772 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Chloro-L-alanine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFP37 | ZFP37 zinc finger protein | 0.9 |
| KLHL23 | kelch-like family member 23 | 0.69 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.61 |
| TSC22D1 | TSC22 domain family, member 1 | 0.6 |
| ZNRD1 | zinc ribbon domain containing 1 | 0.57 |
| ATXN7L3 | ataxin 7-like 3 | 0.55 |
| RNF113A | ring finger protein 113A | 0.54 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.51 |
| POLH | polymerase (DNA directed), eta | 0.5 |
| FLII | flightless I homolog (Drosophila) | 0.48 |
| TCHP | trichoplein, keratin filament binding | 0.47 |
| CBARP | CACN subunit beta associated regulatory protein | 0.43 |
| LATS2 | large tumor suppressor kinase 2 | 0.39 |
| PSEN1 | presenilin 1 | 0.39 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.39 |
| MCOLN3 | mucolipin 3 | 0.38 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | 0.38 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | 0.36 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | 0.36 |
| MT-CO1 | cytochrome c oxidase subunit I | 0.35 |
| KCTD2 | potassium channel tetramerization domain containing 2 | 0.35 |
| PUM2 | pumilio RNA-binding family member 2 | 0.33 |
| PLEKHG6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | 0.33 |
| SLC12A8 | solute carrier family 12, member 8 | 0.33 |
| SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae) | 0.33 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | 0.32 |
| RGL2 | ral guanine nucleotide dissociation stimulator-like 2 | 0.32 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.32 |
| HKDC1 | hexokinase domain containing 1 | 0.32 |
| PARPBP | PARP1 binding protein | 0.31 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.3 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.3 |
| CD58 | CD58 molecule | 0.3 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.3 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | 0.3 |
| ADCY6 | adenylate cyclase 6 | 0.29 |
| EXT1 | exostosin glycosyltransferase 1 | 0.29 |
| BRMS1 | breast cancer metastasis suppressor 1 | 0.29 |
| CCDC66 | coiled-coil domain containing 66 | 0.29 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | 0.29 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | 0.29 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | 0.28 |
| ATE1 | arginyltransferase 1 | 0.28 |
| PROSER1 | proline and serine rich 1 | 0.28 |
| MOCS1 | molybdenum cofactor synthesis 1 | 0.28 |
| WDYHV1 | WDYHV motif containing 1 | 0.28 |
| ZNF92 | zinc finger protein 92 | 0.28 |
| CPNE5 | copine V | 0.27 |
| RBM41 | RNA binding motif protein 41 | 0.27 |
| TMEM248 | transmembrane protein 248 | 0.27 |
| ZNF777 | zinc finger protein 777 | 0.27 |
| SYK | spleen tyrosine kinase | 0.27 |
| PLEKHG3 | pleckstrin homology domain containing, family G (with RhoGef domain) member 3 | 0.26 |
| SELENOF | selenoprotein F | 0.26 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | 0.26 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.26 |
| SRD5A3 | steroid 5 alpha-reductase 3 | 0.26 |
| CCDC150 | coiled-coil domain containing 150 | 0.26 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.26 |
| ELK1 | ELK1, member of ETS oncogene family | 0.25 |
| RAB40C | RAB40C, member RAS oncogene family | 0.25 |
| PRAME | preferentially expressed antigen in melanoma | 0.25 |
| NDRG2 | NDRG family member 2 | 0.25 |
| C15ORF61 | chromosome 15 open reading frame 61 | 0.25 |
| ICA1L | islet cell autoantigen 1,69kDa-like | 0.25 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.25 |
| CDC34 | cell division cycle 34 | 0.25 |
| WWC3 | WWC family member 3 | 0.25 |
| MOCS2 | molybdenum cofactor synthesis 2 | 0.24 |
| TSPAN15 | tetraspanin 15 | 0.24 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.24 |
| YIPF1 | Yip1 domain family, member 1 | 0.24 |
| KAZN | kazrin, periplakin interacting protein | 0.24 |
| FEM1A | fem-1 homolog a (C. elegans) | 0.24 |
| H3-3A | H3.3 histone A | 0.23 |
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | 0.23 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.23 |
| ZNF121 | zinc finger protein 121 | 0.23 |
| TATDN3 | TatD DNase domain containing 3 | 0.23 |
| DUSP5 | dual specificity phosphatase 5 | 0.23 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | 0.23 |
| ZNF544 | zinc finger protein 544 | 0.23 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.23 |
| TMEM184C | transmembrane protein 184C | 0.23 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.23 |
| ZNF669 | zinc finger protein 669 | 0.23 |
| FLCN | folliculin | 0.22 |
| ETNK2 | ethanolamine kinase 2 | 0.22 |
| HIST3H2BB | histone cluster 3, H2bb | 0.22 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | 0.22 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.22 |
| IFI35 | interferon-induced protein 35 | 0.22 |
| IFRD1 | interferon-related developmental regulator 1 | 0.22 |
| OSGEPL1 | O-sialoglycoprotein endopeptidase-like 1 | 0.22 |
| HSPA1L | heat shock 70kDa protein 1-like | 0.22 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.22 |
| CBR3 | carbonyl reductase 3 | 0.22 |
| LRRK2 | leucine-rich repeat kinase 2 | 0.22 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.33 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -1.01 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.86 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | -0.85 |
| ETV6 | ets variant 6 | -0.84 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | -0.79 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.75 |
| HBB | hemoglobin, beta | -0.74 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.65 |
| WNT10B | wingless-type MMTV integration site family, member 10B | -0.64 |
| ZNF428 | zinc finger protein 428 | -0.55 |
| DGKE | diacylglycerol kinase, epsilon 64kDa | -0.54 |
| CNTRL | centriolin | -0.54 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.53 |
| ITPRIPL1 | inositol 1,4,5-trisphosphate receptor interacting protein-like 1 | -0.52 |
| S100A14 | S100 calcium binding protein A14 | -0.52 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | -0.51 |
| CEP57 | centrosomal protein 57kDa | -0.49 |
| ZBTB49 | zinc finger and BTB domain containing 49 | -0.48 |
| CCDC9 | coiled-coil domain containing 9 | -0.46 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.46 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.46 |
| ARHGAP44 | Rho GTPase activating protein 44 | -0.45 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | -0.45 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | -0.44 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.44 |
| F8A1 | coagulation factor VIII-associated 1 | -0.44 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.44 |
| SET | SET nuclear proto-oncogene | -0.44 |
| C12ORF60 | chromosome 12 open reading frame 60 | -0.44 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.43 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | -0.43 |
| MAGEA6 | melanoma antigen family A6 | -0.42 |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | -0.42 |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 | -0.41 |
| DHRS13 | dehydrogenase/reductase (SDR family) member 13 | -0.41 |
| FKBPL | FK506 binding protein like | -0.39 |
| CLIC6 | chloride intracellular channel 6 | -0.39 |
| ENO1 | enolase 1, (alpha) | -0.39 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.39 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.38 |
| INHBA | inhibin, beta A | -0.38 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.38 |
| SPEG | SPEG complex locus | -0.38 |
| MT1F | metallothionein 1F | -0.38 |
| PTBP1 | polypyrimidine tract binding protein 1 | -0.38 |
| ENKD1 | enkurin domain containing 1 | -0.37 |
| HDAC11 | histone deacetylase 11 | -0.37 |
| BIN1 | bridging integrator 1 | -0.36 |
| EWSR1 | EWS RNA-binding protein 1 | -0.36 |
| SLX4 | SLX4 structure-specific endonuclease subunit | -0.36 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.36 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.36 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -0.36 |
| CD82 | CD82 molecule | -0.36 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | -0.35 |
| DENND5A | DENN/MADD domain containing 5A | -0.34 |
| SBSN | suprabasin | -0.34 |
| FCHO1 | FCH domain only 1 | -0.34 |
| TMEM173 | transmembrane protein 173 | -0.34 |
| TJAP1 | tight junction associated protein 1 (peripheral) | -0.33 |
| IQCE | IQ motif containing E | -0.33 |
| B2M | beta-2-microglobulin | -0.33 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | -0.33 |
| PML | promyelocytic leukemia | -0.33 |
| INO80D | INO80 complex subunit D | -0.32 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | -0.32 |
| CRTC3 | CREB regulated transcription coactivator 3 | -0.32 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.32 |
| RNF181 | ring finger protein 181 | -0.32 |
| ZNF362 | zinc finger protein 362 | -0.32 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.32 |
| ING2 | inhibitor of growth family, member 2 | -0.32 |
| CDCA3 | cell division cycle associated 3 | -0.32 |
| PPT2 | palmitoyl-protein thioesterase 2 | -0.32 |
| NCBP2AS2 | NCBP2 antisense 2 (head to head) | -0.31 |
| RNF170 | ring finger protein 170 | -0.31 |
| TMEM63A | transmembrane protein 63A | -0.31 |
| MROH6 | maestro heat-like repeat family member 6 | -0.31 |
| SELENOM | selenoprotein M | -0.31 |
| TMEM200A | transmembrane protein 200A | -0.3 |
| TMEM104 | transmembrane protein 104 | -0.3 |
| TTC9C | tetratricopeptide repeat domain 9C | -0.3 |
| TRAPPC6B | trafficking protein particle complex 6B | -0.3 |
| YBEY | ybeY metallopeptidase (putative) | -0.3 |
| KIZ | kizuna centrosomal protein | -0.3 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.3 |
| LAMC2 | laminin, gamma 2 | -0.3 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.3 |
| COPRS | coordinator of PRMT5, differentiation stimulator | -0.3 |
| CDA | cytidine deaminase | -0.3 |
| ANKRD16 | ankyrin repeat domain 16 | -0.3 |
| CNST | consortin, connexin sorting protein | -0.3 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | -0.3 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | -0.29 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.29 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -0.29 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.29 |
| FANCM | Fanconi anemia, complementation group M | -0.29 |
| INSR | insulin receptor | -0.29 |
