Chloroquine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. (Chemical Entities of Biological Interest Ontology, CHEBI_3638)
External Link http://ctdbase.org/detail.go?type=chem&acc=D002738
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Genes

40 genes/proteins interacting with the chemical Chloroquine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP5 aquaporin 5
ATM ATM serine/threonine kinase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BIRC5 baculoviral IAP repeat containing 5
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAT catalase
CD34 CD34 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
CTSB cathepsin B
CTSD cathepsin D
CTSL cathepsin L
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
GJA1 gap junction protein, alpha 1, 43kDa
GLP1R glucagon-like peptide 1 receptor
GSR glutathione reductase
HSPA1B heat shock 70kDa protein 1B
IL1B interleukin 1, beta
IL2 interleukin 2
IL6 interleukin 6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
NOS2 nitric oxide synthase 2, inducible
POMC proopiomelanocortin
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SCARB1 scavenger receptor class B, member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SQSTM1 sequestosome 1
TNF tumor necrosis factor
TP53 tumor protein p53