Cholangitis Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A bile duct disease that is an inflammation of the bile duct. (Human Disease Ontology, DOID_9446)
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Genes

131 genes associated with the disease Cholangitis in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.024
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.024
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.006
CCHCR1 coiled-coil alpha-helical rod protein 1 2.006
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.006
C6ORF15 chromosome 6 open reading frame 15 2.006
POU5F1 POU class 5 homeobox 1 2.006
TCF19 transcription factor 19 2.006
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.975
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.975
HLA-B major histocompatibility complex, class I, B 1.967
HLA-C major histocompatibility complex, class I, C 1.967
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.947
ZBTB12 zinc finger and BTB domain containing 12 1.947
STK19 serine/threonine kinase 19 1.947
TNXB tenascin XB 1.947
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.947
C4B complement component 4B (Chido blood group) 1.947
SLC44A4 solute carrier family 44, member 4 1.947
C2 complement component 2 1.947
DXO decapping exoribonuclease 1.947
CFB complement factor B 1.947
NELFE negative elongation factor complex member E 1.947
C4A complement component 4A (Rodgers blood group) 1.947
NEU1 sialidase 1 (lysosomal sialidase) 1.947
MUC22 mucin 22 1.932
BSN bassoon presynaptic cytomatrix protein 1.901
AMIGO3 adhesion molecule with Ig-like domain 3 1.901
IP6K1 inositol hexakisphosphate kinase 1 1.901
MST1 macrophage stimulating 1 1.901
GMPPB GDP-mannose pyrophosphorylase B 1.901
APEH acylaminoacyl-peptide hydrolase 1.901
RNF123 ring finger protein 123 1.901
FOXP1 forkhead box P1 1.83
HLA-DMA major histocompatibility complex, class II, DM alpha 1.768
HLA-DMB major histocompatibility complex, class II, DM beta 1.768
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.768
HLA-DOA major histocompatibility complex, class II, DO alpha 1.768
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.768
BRD2 bromodomain containing 2 1.768
ATXN2 ataxin 2 1.729
SH2B3 SH2B adaptor protein 3 1.729
PHETA1 PH domain containing endocytic trafficking adaptor 1 1.729
CUX2 cut-like homeobox 2 1.729
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.71
MICB MHC class I polypeptide-related sequence B 1.706
MCCD1 mitochondrial coiled-coil domain 1 1.706
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 1.706
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 1.706
LTA lymphotoxin alpha 1.706
LST1 leukocyte specific transcript 1 1.706
LTB lymphotoxin beta (TNF superfamily, member 3) 1.706
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 1.706
TNF tumor necrosis factor 1.706
NCR3 natural cytotoxicity triggering receptor 3 1.706
BAD BCL2-associated agonist of cell death 1.606
CATSPERZ catsper channel auxiliary subunit zeta 1.606
FKBP2 FK506 binding protein 2, 13kDa 1.606
PRDX5 peroxiredoxin 5 1.606
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 1.606
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 1.606
GPR137 G protein-coupled receptor 137 1.606
ESRRA estrogen-related receptor alpha 1.606
CCDC88B coiled-coil domain containing 88B 1.606
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 1.606
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 1.606
KCNK4 potassium channel, two pore domain subfamily K, member 4 1.606
HES5 hes family bHLH transcription factor 5 1.592
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 1.592
TTC34 tetratricopeptide repeat domain 34 1.592
PANK4 pantothenate kinase 4 1.592
MMEL1 membrane metallo-endopeptidase-like 1 1.592
PRXL2B peroxiredoxin like 2B 1.592
PLCH2 phospholipase C, eta 2 1.592
CLEC16A C-type lectin domain family 16, member A 1.581
DACT3 dishevelled-binding antagonist of beta-catenin 3 1.556
PRKD2 protein kinase D2 1.556
GNG8 guanine nucleotide binding protein (G protein), gamma 8 1.556
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 1.556
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.556
FKRP fukutin related protein 1.556
STRN4 striatin, calmodulin binding protein 4 1.556
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 1.556
TFF1 trefoil factor 1 1.512
UBASH3A ubiquitin associated and SH3 domain containing A 1.512
TFF2 trefoil factor 2 1.512
TMPRSS3 transmembrane protease, serine 3 1.512
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 1.512
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 1.512
DOK6 docking protein 6 1.503
CD226 CD226 molecule 1.503
RTTN rotatin 1.503
ACOXL acyl-CoA oxidase-like 1.428
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 1.31
AQP12A aquaporin 12A 1.275
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 1.275
DUSP28 dual specificity phosphatase 28 1.275
GPR35 G protein-coupled receptor 35 1.275
CAPN10 calpain 10 1.275
AQP12B aquaporin 12B 1.275
ANKMY1 ankyrin repeat and MYND domain containing 1 1.275
KIF1A kinesin family member 1A 1.275
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 1.173
SIK2 salt-inducible kinase 2 1.173
ALG9 ALG9, alpha-1,2-mannosyltransferase 1.173
SLC48A1 solute carrier family 48 (heme transporter), member 1 1.131
HDAC7 histone deacetylase 7 1.131
ENDOU endonuclease, polyU-specific 1.131
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 1.131
CD28 CD28 molecule 1.116
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 1.089
NKX6-2 NK6 homeobox 2 1.089
TCF4 transcription factor 4 1.089
BRWD1 bromodomain and WD repeat domain containing 1 1.075
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 1.075
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 1.055
RBM17 RNA binding motif protein 17 1.055
IL15RA interleukin 15 receptor, alpha 1.055
IL2RA interleukin 2 receptor, alpha 1.055
SGSM1 small G protein signaling modulator 1 1.012
KIAA1671 KIAA1671 1.012
PIWIL3 piwi-like RNA-mediated gene silencing 3 1.012
FLNC filamin C, gamma 0.925
KCP kielin/chordin-like protein 0.925
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.925
TNPO3 transportin 3 0.925
IRF5 interferon regulatory factor 5 0.925
IL21 interleukin 21 0.819
IL2 interleukin 2 0.819
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.732
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.732