Cholelithiasis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS). (Experimental Factor Ontology, EFO_0004799)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D002769
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Genes

137 genes/proteins associated with the disease Cholelithiasis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
ASPG asparaginase 2.88009
TNF tumor necrosis factor 1.92579
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.84464
CCL2 chemokine (C-C motif) ligand 2 1.76309
IL6 interleukin 6 1.71748
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.70512
IFNG interferon, gamma 1.68932
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.67697
FAS Fas cell surface death receptor 1.65864
IL1B interleukin 1, beta 1.65
CCL5 chemokine (C-C motif) ligand 5 1.61154
BAX BCL2-associated X protein 1.60781
BCL2 B-cell CLL/lymphoma 2 1.56681
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.54888
TGFB1 transforming growth factor, beta 1 1.53332
TP53 tumor protein p53 1.51456
JUN jun proto-oncogene 1.50776
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.46304
CRP C-reactive protein, pentraxin-related 1.44409
VCAM1 vascular cell adhesion molecule 1 1.44327
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.43293
PLAT plasminogen activator, tissue 1.43266
APOA1 apolipoprotein A-I 1.43266
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.43048
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.42669
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.40288
CAT catalase 1.39897
NOS2 nitric oxide synthase 2, inducible 1.39114
BCL2L1 BCL2-like 1 1.34459
ICAM1 intercellular adhesion molecule 1 1.32993
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.32369
F2 coagulation factor II (thrombin) 1.3231
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.32132
MAPK3 mitogen-activated protein kinase 3 1.31178
MAPK1 mitogen-activated protein kinase 1 1.3039
DHCR24 24-dehydrocholesterol reductase 1.30208
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.29812
PPARG peroxisome proliferator-activated receptor gamma 1.29626
IL2 interleukin 2 1.28058
NPPA natriuretic peptide A 1.28058
EDN1 endothelin 1 1.27564
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 1.26607
VEGFA vascular endothelial growth factor A 1.26576
PPARA peroxisome proliferator-activated receptor alpha 1.26205
FASN fatty acid synthase 1.25929
EGR2 early growth response 2 1.25776
MMP2 matrix metallopeptidase 2 1.25059
IL12B interleukin 12B 1.23011
APOB apolipoprotein B 1.22758
NPPB natriuretic peptide B 1.22599
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.22306
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.2208
KRT8 keratin 8, type II 1.21855
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.21468
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.2137
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.21173
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.20262
COL6A3 collagen, type VI, alpha 3 1.19704
IGFBP1 insulin-like growth factor binding protein 1 1.19312
GSTM3 glutathione S-transferase mu 3 (brain) 1.19213
SLCO1B1 solute carrier organic anion transporter family, member 1B1 1.18489
GADD45A growth arrest and DNA-damage-inducible, alpha 1.18193
MMP9 matrix metallopeptidase 9 1.17366
ALB albumin 1.17101
REN renin 1.16335
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.15865
FADS1 fatty acid desaturase 1 1.15831
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.15391
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 1.15189
PCNA proliferating cell nuclear antigen 1.15122
SARAF store-operated calcium entry-associated regulatory factor 1.1485
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.14678
PLLP plasmolipin 1.14268
PKLR pyruvate kinase, liver and RBC 1.14132
ECH1 enoyl CoA hydratase 1, peroxisomal 1.13862
CCND1 cyclin D1 1.12872
SOD2 superoxide dismutase 2, mitochondrial 1.12461
MRAP melanocortin 2 receptor accessory protein 1.12391
THRSP thyroid hormone responsive 1.12288
FASLG Fas ligand (TNF superfamily, member 6) 1.12254
DDIT3 DNA-damage-inducible transcript 3 1.12117
MCL1 myeloid cell leukemia 1 1.11911
FGB fibrinogen beta chain 1.11741
NOS3 nitric oxide synthase 3 (endothelial cell) 1.10942
LPL lipoprotein lipase 1.10246
FAM107A family with sequence similarity 107, member A 1.10175
LHB luteinizing hormone beta polypeptide 1.09751
CXCL10 chemokine (C-X-C motif) ligand 10 1.09751
FMO1 flavin containing monooxygenase 1 1.09716
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.09611
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 1.09366
CTSL cathepsin L 1.09047
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.09047
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.08762
PRL prolactin 1.08549
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.08266
LOX lysyl oxidase 1.08196
FOS FBJ murine osteosarcoma viral oncogene homolog 1.08161
PPARD peroxisome proliferator-activated receptor delta 1.07768
ATF3 activating transcription factor 3 1.07376
FN1 fibronectin 1 1.07376
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.07093
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.06952
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 1.06808
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.06734
TIMP3 TIMP metallopeptidase inhibitor 3 1.06479
THBS1 thrombospondin 1 1.06044
INS insulin 1.06044
CYBA cytochrome b-245, alpha polypeptide 1.05864
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.05793
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.05461
SLCO1B3 solute carrier organic anion transporter family, member 1B3 1.05312
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 1.05052
ACSL1 acyl-CoA synthetase long-chain family member 1 1.04978
CFLAR CASP8 and FADD-like apoptosis regulator 1.04868
GSK3B glycogen synthase kinase 3 beta 1.04611
RECQL5 RecQ protein-like 5 1.04538
RHOC ras homolog family member C 1.04538
LEP leptin 1.04389
TIMP1 TIMP metallopeptidase inhibitor 1 1.03901
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.03493
BIRC5 baculoviral IAP repeat containing 5 1.03456
NDRG1 N-myc downstream regulated 1 1.03308
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 1.03197
MTUS1 microtubule associated tumor suppressor 1 1.02933
CRYAB crystallin, alpha B 1.02896
HMOX1 heme oxygenase 1 1.02746
ORM2 orosomucoid 2 1.02634
CES1 carboxylesterase 1 1.02634
IL12A interleukin 12A 1.02373
TRIB3 tribbles pseudokinase 3 1.02225
CALB1 calbindin 1, 28kDa 1.02114
ATF4 activating transcription factor 4 1.01852
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.01512
SCARB1 scavenger receptor class B, member 1 1.01361
ACADL acyl-CoA dehydrogenase, long chain 1.01249
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.01137