Choline metabolism in cancer Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS and PI3K-AKT pathways, and transcription factors associated with oncogenesis such as hypoxia-inducible factor 1 (HIF1) mediate overexpression and activation of choline cycle enzymes, which causes increased levels of choline-containing precursors and breakdown products of membrane phospholipids. These products of choline phospholipid metabolism, such as phosphocholine (PCho), diacylglycerol (DAG) and phosphatidic acid, may function as second messengers that are essential for the mitogenic activity of growth factors, particularly in the activation of the ras-raf-1-MAPK cascade and protein kinase C pathway. (Kyoto Encyclopedia of Genes and Genomes, hsa05231)
External Link https://www.kegg.jp/entry/hsa05231
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98 proteins participating in the Choline metabolism in cancer pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
CHKA choline kinase alpha
CHKB choline kinase beta
CHPT1 choline phosphotransferase 1
CLSTN1 calsyntenin 1
DAND5 DAN domain family member 5, BMP antagonist
DGKA diacylglycerol kinase, alpha 80kDa
DGKB diacylglycerol kinase, beta 90kDa
DGKD diacylglycerol kinase, delta 130kDa
DGKE diacylglycerol kinase, epsilon 64kDa
DGKG diacylglycerol kinase, gamma 90kDa
DGKH diacylglycerol kinase, eta
DGKI diacylglycerol kinase, iota
DGKK diacylglycerol kinase, kappa
DGKQ diacylglycerol kinase, theta 110kDa
DGKZ diacylglycerol kinase, zeta
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
GRB2 growth factor receptor-bound protein 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRAS Harvey rat sarcoma viral oncogene homolog
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough
JUN jun proto-oncogene
LNCEGFL7OS lncRNA EGFL7 opposite strand
LYPLA1 lysophospholipase I
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCOA3 nuclear receptor coactivator 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLA2G4D phospholipase A2, group IVD (cytosolic)
PLA2G4E phospholipase A2, group IVE
PLA2G4F phospholipase A2, group IVF
PLCG1 phospholipase C, gamma 1
PLD2 phospholipase D2
PLPP1 phospholipid phosphatase 1
PLPP2 phospholipid phosphatase 2
PLPP3 phospholipid phosphatase 3
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PRKCSH protein kinase C substrate 80K-H
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALGDS ral guanine nucleotide dissociation stimulator
RHEB Ras homolog enriched in brain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC44A2 solute carrier family 44 (choline transporter), member 2
SLC44A3 solute carrier family 44, member 3
SLC44A4 solute carrier family 44, member 4
SLC44A5 solute carrier family 44, member 5
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3