Chondrocalcinosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint. (Human Disease Ontology, DOID_1156)
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Genes

167 genes co-occuring with the disease Chondrocalcinosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ANKH ANKH inorganic pyrophosphate transport regulator 3.167
ALPL alkaline phosphatase, liver/bone/kidney 2.636
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.516
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2.456
IL1B interleukin 1, beta 2.368
NLRP3 NLR family, pyrin domain containing 3 2.342
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.324
CRP C-reactive protein, pentraxin-related 2.268
PTH parathyroid hormone 2.216
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 2.153
CASR calcium-sensing receptor 2.151
IL18 interleukin 18 2.109
IL1A interleukin 1, alpha 2.041
NLRC4 NLR family, CARD domain containing 4 2.034
CLCNKB chloride channel, voltage-sensitive Kb 1.971
ACAN aggrecan 1.968
PPA1 pyrophosphatase (inorganic) 1 1.963
NLRP1 NLR family, pyrin domain containing 1 1.959
MEFV Mediterranean fever 1.954
IL1R1 interleukin 1 receptor, type I 1.941
HFE hemochromatosis 1.898
PYCARD PYD and CARD domain containing 1.87
AIM2 absent in melanoma 2 1.829
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.823
IL6 interleukin 6 1.786
FXYD2 FXYD domain containing ion transport regulator 2 1.776
TNF tumor necrosis factor 1.769
TRPM6 transient receptor potential cation channel, subfamily M, member 6 1.758
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 1.73
MGP matrix Gla protein 1.721
COMP cartilage oligomeric matrix protein 1.709
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.694
PRTN3 proteinase 3 1.682
IL1RN interleukin 1 receptor antagonist 1.666
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.635
PHOSPHO1 phosphatase, orphan 1 1.634
NLRP12 NLR family, pyrin domain containing 12 1.622
MMP3 matrix metallopeptidase 3 1.619
MMP13 matrix metallopeptidase 13 1.618
BSND barttin CLCNK-type chloride channel accessory beta subunit 1.598
COL2A1 collagen, type II, alpha 1 1.58
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 1.577
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.566
CASP5 caspase 5, apoptosis-related cysteine peptidase 1.564
PPA2 pyrophosphatase (inorganic) 2 1.563
CTSB cathepsin B 1.548
GCM2 glial cells missing homolog 2 (Drosophila) 1.54
PANX1 pannexin 1 1.529
RUNX2 runt-related transcription factor 2 1.51
BGLAP bone gamma-carboxyglutamate (gla) protein 1.472
CLCNKA chloride channel, voltage-sensitive Ka 1.469
MYD88 myeloid differentiation primary response 88 1.465
CXCL8 chemokine (C-X-C motif) ligand 8 1.459
MVK mevalonate kinase 1.457
NOD2 nucleotide-binding oligomerization domain containing 2 1.451
SPP1 secreted phosphoprotein 1 1.445
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 1.442
TLR2 toll-like receptor 2 1.437
ALB albumin 1.423
NAIP NLR family, apoptosis inhibitory protein 1.419
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.395
GSDMD gasdermin D 1.388
XDH xanthine dehydrogenase 1.377
NEK7 NIMA-related kinase 7 1.373
AGBL2 ATP/GTP binding protein-like 2 1.372
TGFB1 transforming growth factor, beta 1 1.368
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 1.361
BMP2 bone morphogenetic protein 2 1.346
PRG4 proteoglycan 4 1.346
FGF23 fibroblast growth factor 23 1.345
IL1RAP interleukin 1 receptor accessory protein 1.344
PHEX phosphate regulating endopeptidase homolog, X-linked 1.34
IAPP islet amyloid polypeptide 1.335
SYK spleen tyrosine kinase 1.322
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.317
TLR4 toll-like receptor 4 1.315
NLRP6 NLR family, pyrin domain containing 6 1.312
IL17A interleukin 17A 1.31
CLDN16 claudin 16 1.303
TRPV5 transient receptor potential cation channel, subfamily V, member 5 1.303
REN renin 1.302
CARD8 caspase recruitment domain family, member 8 1.3
POMC proopiomelanocortin 1.291
IFNG interferon, gamma 1.287
CIITA class II, major histocompatibility complex, transactivator 1.283
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 1.27
RSPO4 R-spondin 4 1.265
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 1.246
CARD18 caspase recruitment domain family, member 18 1.242
IL18BP interleukin 18 binding protein 1.238
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 1.232
HJV hemojuvelin BMP co-receptor 1.226
COL10A1 collagen, type X, alpha 1 1.221
AHSG alpha-2-HS-glycoprotein 1.22
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 1.218
NLRP7 NLR family, pyrin domain containing 7 1.216
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.216
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.215
ALPP alkaline phosphatase, placental 1.21
IBSP integrin-binding sialoprotein 1.209
TFR2 transferrin receptor 2 1.209
PTHLH parathyroid hormone-like hormone 1.207
CDC73 cell division cycle 73 1.206
IL10 interleukin 10 1.193
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 1.188
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 1.178
KL klotho 1.174
SP7 Sp7 transcription factor 1.172
SOST sclerostin 1.171
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 1.17
TXNIP thioredoxin interacting protein 1.169
NLRP10 NLR family, pyrin domain containing 10 1.167
UCMA upper zone of growth plate and cartilage matrix associated 1.167
MLKL mixed lineage kinase domain-like 1.162
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 1.152
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.145
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 1.14
GDF5 growth differentiation factor 5 1.134
CSF3 colony stimulating factor 3 (granulocyte) 1.134
IL33 interleukin 33 1.131
HAMP hepcidin antimicrobial peptide 1.127
COL11A2 collagen, type XI, alpha 2 1.126
COL1A1 collagen, type I, alpha 1 1.125
CKM creatine kinase, muscle 1.118
CP ceruloplasmin (ferroxidase) 1.117
IL18RAP interleukin 18 receptor accessory protein 1.107
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.106
CKMT1B creatine kinase, mitochondrial 1B 1.105
CKB creatine kinase, brain 1.102
IL1F10 interleukin 1 family, member 10 (theta) 1.101
MYO1E myosin IE 1.101
NLRP4 NLR family, pyrin domain containing 4 1.099
BMP6 bone morphogenetic protein 6 1.098
INS insulin 1.095
COL9A1 collagen, type IX, alpha 1 1.088
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 1.081
IL36R interleukin 36 receptor 1.079
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.071
SOX9 SRY (sex determining region Y)-box 9 1.068
IGF1 insulin-like growth factor 1 (somatomedin C) 1.068
ACP5 acid phosphatase 5, tartrate resistant 1.066
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.066
PTH1R parathyroid hormone 1 receptor 1.063
IL18R1 interleukin 18 receptor 1 1.062
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.061
IL36RN interleukin 36 receptor antagonist 1.058
CTSK cathepsin K 1.057
ELANE elastase, neutrophil expressed 1.053
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.053
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 1.048
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.041
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.04
B2M beta-2-microglobulin 1.04
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.037
COL6A1 collagen, type VI, alpha 1 1.037
MMP1 matrix metallopeptidase 1 1.03
CD4 CD4 molecule 1.024
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 1.023
CCL2 chemokine (C-C motif) ligand 2 1.021
STX16 syntaxin 16 1.019
ESX1 ESX homeobox 1 1.019
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 1.018
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.017
CTSS cathepsin S 1.015
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 1.006
IL37 interleukin 37 1.002
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.0