Chondrosarcoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)|A malignant mesenchymal tumor arising from cartilage-forming tissues involving the bones. It affects middle-aged to elderly adults, and the pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion. (Experimental Factor Ontology, EFO_0000333)
External Link https://www.disgenet.org/browser/0/1/0/C0855012
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Genes

350 genes associated with the disease Chondrosarcoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACAN aggrecan
ACTB actin, beta
ACVR1 activin A receptor, type I
ACVR2A activin A receptor, type IIA
ADAM15 ADAM metallopeptidase domain 15
ADAM8 ADAM metallopeptidase domain 8
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTSL1 ADAMTS-like 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AGER advanced glycosylation end product-specific receptor
AHCY adenosylhomocysteinase
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AHSG alpha-2-HS-glycoprotein
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AIRE autoimmune regulator
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALX1 ALX homeobox 1
AMACR alpha-methylacyl-CoA racemase
AMBP alpha-1-microglobulin/bikunin precursor
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANXA5 annexin A5
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APRT adenine phosphoribosyltransferase
AREG amphiregulin
ARHGAP24 Rho GTPase activating protein 24
ATG12 autophagy related 12
ATR ATR serine/threonine kinase
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCOR BCL6 corepressor
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP2 bone morphogenetic protein 2
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRD4 bromodomain containing 4
C4BPA complement component 4 binding protein, alpha
CA11 carbonic anhydrase XI
CARD14 caspase recruitment domain family, member 14
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCK cholecystokinin
CCL11 chemokine (C-C motif) ligand 11
CCL5 chemokine (C-C motif) ligand 5
CCN2 cellular communication network factor 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD44 CD44 molecule (Indian blood group)
CD6 CD6 molecule
CD68 CD68 molecule
CDC25A cell division cycle 25A
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CHEK1 checkpoint kinase 1
CHN1 chimerin 1
CIP2A cellular inhibitor of PP2A
CKAP4 cytoskeleton-associated protein 4
CLCN3 chloride channel, voltage-sensitive 3
CLU clusterin
COL11A2 collagen, type XI, alpha 2
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL4A5 collagen, type IV, alpha 5
COMMD3-BMI1 COMMD3-BMI1 readthrough
COMP cartilage oligomeric matrix protein
COX2
CREBRF CREB3 regulatory factor
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSAG1 chondrosarcoma associated gene 1
CSAG2 CSAG family, member 2
CSAG3 CSAG family, member 3
CSPG4 chondroitin sulfate proteoglycan 4
CTAG1A cancer/testis antigen 1A
CTAG1B cancer/testis antigen 1B
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
DAXX death-domain associated protein
DCN decorin
DCPS decapping enzyme, scavenger
DISC1 disrupted in schizophrenia 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNER delta/notch-like EGF repeat containing
DRD3 dopamine receptor D3
EDIL3 EGF-like repeats and discoidin I-like domains 3
EDN1 endothelin 1
EFNA5 ephrin-A5
EGFR epidermal growth factor receptor
ELSPBP1 epididymal sperm binding protein 1
ENG endoglin
EPAS1 endothelial PAS domain protein 1
EPHA1 EPH receptor A1
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ESRRB estrogen-related receptor beta
ETV5 ets variant 5
EWSR1 EWS RNA-binding protein 1
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FERMT2 fermitin family member 2
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOXA1 forkhead box A1
GDE1 glycerophosphodiester phosphodiesterase 1
GDNF glial cell derived neurotrophic factor
GFAP glial fibrillary acidic protein
GFM1 G elongation factor, mitochondrial 1
GLB1 galactosidase, beta 1
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GLS glutaminase
GPBAR1 G protein-coupled bile acid receptor 1
GPC3 glypican 3
GRAP2 GRB2-related adaptor protein 2
H3F3A H3 histone, family 3A
H3F3B H3 histone, family 3B (H3.3B)
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HDAC7 histone deacetylase 7
HDC histidine decarboxylase
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPG2 heparan sulfate proteoglycan 2
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI16 interferon, gamma-inducible protein 16
IFT88 intraflagellar transport 88
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IHH indian hedgehog
IL10 interleukin 10
IL11 interleukin 11
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
IRF5 interferon regulatory factor 5
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITM2B integral membrane protein 2B
JUNB jun B proto-oncogene
KDM1A lysine (K)-specific demethylase 1A
KDM6A lysine (K)-specific demethylase 6A
KDM6B lysine (K)-specific demethylase 6B
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK3 kallikrein-related peptidase 3
KMT2A lysine (K)-specific methyltransferase 2A
LATS1 large tumor suppressor kinase 1
LBH limb bud and heart development
LDHA lactate dehydrogenase A
LECT1 leukocyte cell derived chemotaxin 1
LEP leptin
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MAGEA4 melanoma antigen family A4
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2 microtubule-associated protein 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MATN3 matrilin 3
MBD2 methyl-CpG binding domain protein 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MFAP1 microfibrillar-associated protein 1
MIB1 mindbomb E3 ubiquitin protein ligase 1
MID1 midline 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP28 matrix metallopeptidase 28
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MTAP methylthioadenosine phosphorylase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOG myogenin (myogenic factor 4)
NAMPT nicotinamide phosphoribosyltransferase
NAPRT nicotinate phosphoribosyltransferase
NCOA2 nuclear receptor coactivator 2
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NOV nephroblastoma overexpressed
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OSCP1 organic solute carrier partner 1
PARP1 poly (ADP-ribose) polymerase 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDCD5 programmed cell death 5
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPN podoplanin
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11
PRDX2 peroxiredoxin 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRMT1 protein arginine methyltransferase 1
PRNP prion protein
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTH1R parathyroid hormone 1 receptor
PTHLH parathyroid hormone-like hormone
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RARG retinoic acid receptor, gamma
RB1 retinoblastoma 1
RETN resistin
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASE3 ribonuclease, RNase A family, 3
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPE65 retinal pigment epithelium-specific protein 65kDa
RRAD Ras-related associated with diabetes
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
S100A1 S100 calcium binding protein A1
S100B S100 calcium binding protein B
SATB2 SATB homeobox 2
SDC2 syndecan 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN2 sestrin 2
SFRP5 secreted frizzled-related protein 5
SFTPC surfactant protein C
SH2B2 SH2B adaptor protein 2
SIRT1 sirtuin 1
SIX3 SIX homeobox 3
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC12A9 solute carrier family 12, member 9
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD1 SMAD family member 1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMO smoothened, frizzled class receptor
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOCS3 suppressor of cytokine signaling 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAZ tafazzin
TBX3 T-box 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TET1 tet methylcytosine dioxygenase 1
TFEB transcription factor EB
TFG TRK-fused gene
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLR1 toll-like receptor 1
TLR6 toll-like receptor 6
TM7SF2 transmembrane 7 superfamily member 2
TMSB4X thymosin beta 4, X-linked
TNC tenascin C
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOB1 transducer of ERBB2, 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TRAF4 TNF receptor-associated factor 4
TUBA1B tubulin, alpha 1b
TUBB3 tubulin, beta 3 class III
TUSC3 tumor suppressor candidate 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UVRAG UV radiation resistance associated
VCAM1 vascular cell adhesion molecule 1
VCAN versican
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
WIF1 WNT inhibitory factor 1
WISP1 WNT1 inducible signaling pathway protein 1
WISP3 WNT1 inducible signaling pathway protein 3
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YAP1 Yes-associated protein 1
ZBTB7A zinc finger and BTB domain containing 7A