Choriocarcinoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected. (Experimental Factor Ontology, EFO_0002893)
External Link https://www.disgenet.org/browser/0/1/0/C0008497
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Genes

402 genes associated with the disease Choriocarcinoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACKR3 atypical chemokine receptor 3
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
ADA adenosine deaminase
ADM adrenomedullin
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHR aryl hydrocarbon receptor
AIRE autoimmune regulator
AKIRIN2 akirin 2
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALPG alkaline phosphatase, germ cell
ALPI alkaline phosphatase, intestinal
ALPP alkaline phosphatase, placental
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPTL1 angiopoietin-like 1
ANXA5 annexin A5
AP5B1 adaptor-related protein complex 5, beta 1 subunit
APC adenomatous polyposis coli
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
APRT adenine phosphoribosyltransferase
AREG amphiregulin
ARFRP1 ADP-ribosylation factor related protein 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ASCL2 achaete-scute family bHLH transcription factor 2
ASRGL1 asparaginase like 1
ATG5 autophagy related 5
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATRNL1 attractin-like 1
B2M beta-2-microglobulin
BBC3 BCL2 binding component 3
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRMS1 breast cancer metastasis suppressor 1
C1QL1 complement component 1, q subcomponent-like 1
CALB1 calbindin 1, 28kDa
CALCA calcitonin-related polypeptide alpha
CALCRL calcitonin receptor-like
CALR calreticulin
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL27 chemokine (C-C motif) ligand 27
CCNB1 cyclin B1
CCND2 cyclin D2
CCR1 chemokine (C-C motif) receptor 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD1D CD1d molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGA glycoprotein hormones, alpha polypeptide
CGB chorionic gonadotropin, beta polypeptide
CGB5 chorionic gonadotropin, beta polypeptide 5
CGB8 chorionic gonadotropin, beta polypeptide 8
CHGB chromogranin B
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CIB2 calcium and integrin binding family member 2
CIITA class II, major histocompatibility complex, transactivator
CKAP4 cytoskeleton-associated protein 4
CLIC1 chloride intracellular channel 1
CMA1 chymase 1, mast cell
COIL coilin
CRH corticotropin releasing hormone
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CSH2 chorionic somatomammotropin hormone 2
CSNK1D casein kinase 1, delta
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUL7 cullin 7
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHFR dihydrofolate reductase
DHRS11 dehydrogenase/reductase (SDR family) member 11
DIO2 deiodinase, iodothyronine, type II
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DLX3 distal-less homeobox 3
DLX4 distal-less homeobox 4
DNASE1 deoxyribonuclease I
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DOC2A double C2-like domains, alpha
EBP emopamil binding protein (sterol isomerase)
EDN1 endothelin 1
EDN2 endothelin 2
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ENG endoglin
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EPHB2 EPH receptor B2
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERV3-1 endogenous retrovirus group 3, member 1
ERVW-1 endogenous retrovirus group W, member 1
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F2R coagulation factor II (thrombin) receptor
F8 coagulation factor VIII, procoagulant component
FABP3 fatty acid binding protein 3, muscle and heart
FBXW8 F-box and WD repeat domain containing 8
FDX1 ferredoxin 1
FERMT2 fermitin family member 2
FGF2 fibroblast growth factor 2 (basic)
FGF4 fibroblast growth factor 4
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
FOXC2 forkhead box C2
FST follistatin
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GATAD1 GATA zinc finger domain containing 1
GCM1 glial cells missing homolog 1 (Drosophila)
GH1 growth hormone 1
GH2 growth hormone 2
GJA5 gap junction protein, alpha 5, 40kDa
GKN1 gastrokine 1
GNRHR gonadotropin-releasing hormone receptor
GORASP1 golgi reassembly stacking protein 1, 65kDa
GPER1 G protein-coupled estrogen receptor 1
GPR1 G protein-coupled receptor 1
GUCA1A guanylate cyclase activator 1A (retina)
HDAC3 histone deacetylase 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HLA-A major histocompatibility complex, class I, A
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HM13 histocompatibility (minor) 13
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HPSE heparanase
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPB3 heat shock 27kDa protein 3
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTRA1 HtrA serine peptidase 1
IAPP islet amyloid polypeptide
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNA2 interferon, alpha 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IL11 interleukin 11
IL13 interleukin 13
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL4 interleukin 4
IL6 interleukin 6
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
INHA inhibin, alpha
INSL4 insulin-like 4 (placenta)
INSR insulin receptor
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG1 jagged 1
JAK2 Janus kinase 2
JAKMIP2 janus kinase and microtubule interacting protein 2
JMJD6 jumonji domain containing 6
KDR kinase insert domain receptor
KIF7 kinesin family member 7
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LASP1 LIM and SH3 protein 1
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS13 lectin, galactoside-binding, soluble, 13
LIF leukemia inhibitory factor
LIFR leukemia inhibitory factor receptor alpha
LIN28A lin-28 homolog A (C. elegans)
LIN28B lin-28 homolog B (C. elegans)
LNPEP leucyl/cystinyl aminopeptidase
LRP1 low density lipoprotein receptor-related protein 1
MAGT1 magnesium transporter 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MCL1 myeloid cell leukemia 1
MCM8 minichromosome maintenance complex component 8
MCTS1 malignant T cell amplified sequence 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MFAP1 microfibrillar-associated protein 1
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MIA melanoma inhibitory activity
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MRC1 mannose receptor, C type 1
MSH3 mutS homolog 3
MSTN myostatin
MTX1 metaxin 1
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NANOG Nanog homeobox
NAT10 N-acetyltransferase 10 (GCN5-related)
NES nestin
NFIL3 nuclear factor, interleukin 3 regulated
NLRP7 NLR family, pyrin domain containing 7
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP53 NOP53 ribosome biogenesis factor
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NR5A1 nuclear receptor subfamily 5, group A, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PAEP progestagen-associated endometrial protein
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PARD6A par-6 family cell polarity regulator alpha
PAX8 paired box 8
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDLIM3 PDZ and LIM domain 3
PDPN podoplanin
PEG3 paternally expressed 3
PGF placental growth factor
PGR progesterone receptor
PGRMC1 progesterone receptor membrane component 1
PHB2 prohibitin 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIM3 Pim-3 proto-oncogene, serine/threonine kinase
PITRM1 pitrilysin metallopeptidase 1
PITX2 paired-like homeodomain 2
PKM pyruvate kinase, muscle
PLAA phospholipase A2-activating protein
PLIN2 perilipin 2
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PROK1 prokineticin 1
PSCA prostate stem cell antigen
PTEN phosphatase and tensin homolog
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
RFC2 replication factor C (activator 1) 2, 40kDa
RIN2 Ras and Rab interactor 2
RORA RAR-related orphan receptor A
RPE65 retinal pigment epithelium-specific protein 65kDa
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RSPO3 R-spondin 3
RXRA retinoid X receptor, alpha
S100A11 S100 calcium binding protein A11
SALL4 spalt-like transcription factor 4
SATB1 SATB homeobox 1
SDC1 syndecan 1
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SELK selenoprotein K
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SET SET nuclear proto-oncogene
SFRP2 secreted frizzled-related protein 2
SGSM3 small G protein signaling modulator 3
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SOX2 SRY (sex determining region Y)-box 2
SPATA9 spermatogenesis associated 9
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRSF1 serine/arginine-rich splicing factor 1
STARD7 StAR-related lipid transfer (START) domain containing 7
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STIP1 stress-induced phosphoprotein 1
STK11 serine/threonine kinase 11
STOX1 storkhead box 1
SUGP1 SURP and G patch domain containing 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMED2 transmembrane emp24 domain trafficking protein 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TRIML2 tripartite motif family-like 2
TSPO translocator protein (18kDa)
TTR transthyretin
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UVRAG UV radiation resistance associated
VASP vasodilator-stimulated phosphoprotein
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VSIR V-set immunoregulatory receptor
WDR48 WD repeat domain 48
WNK1 WNK lysine deficient protein kinase 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB7A zinc finger and BTB domain containing 7A
ZEB2 zinc finger E-box binding homeobox 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF248 zinc finger protein 248
ZNHIT2 zinc finger, HIT-type containing 2