| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ciclopirox perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ciclopirox_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.155714 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.131153 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.115892 |
| TMEM41B | transmembrane protein 41B | 0.112614 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.108173 |
| YBX3 | Y box binding protein 3 | 0.105328 |
| YAP1 | Yes-associated protein 1 | 0.0927343 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0927116 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.091181 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0882674 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0782541 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0626318 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0610856 |
| RRM2 | ribonucleotide reductase M2 | 0.0589305 |
| PDGFC | platelet derived growth factor C | 0.0588668 |
| CCNL1 | cyclin L1 | 0.0585278 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0545262 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0532979 |
| TPI1 | triosephosphate isomerase 1 | 0.0521428 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0519906 |
| RTN4 | reticulon 4 | 0.0514241 |
| VMP1 | vacuole membrane protein 1 | 0.0500898 |
| JMJD1C | jumonji domain containing 1C | 0.0474991 |
| PCBP2 | poly(rC) binding protein 2 | 0.046669 |
| UBC | ubiquitin C | 0.0464495 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0444641 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0435227 |
| RPS7 | ribosomal protein S7 | 0.0417596 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0408668 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0406726 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0388931 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0388221 |
| RPS12 | ribosomal protein S12 | 0.0378289 |
| KDM5A | lysine (K)-specific demethylase 5A | 0.0373849 |
| RPL9 | ribosomal protein L9 | 0.0365761 |
| PFN1 | profilin 1 | 0.0364891 |
| MCL1 | myeloid cell leukemia 1 | 0.0362025 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0358284 |
| TUBA1B | tubulin, alpha 1b | 0.0355374 |
| ERBIN | erbb2 interacting protein | 0.0346009 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0332922 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0327731 |
| XPOT | exportin, tRNA | 0.0323434 |
| CLTC | clathrin, heavy chain (Hc) | 0.0320593 |
| H3-3B | H3.3 histone B | 0.0314703 |
| PCM1 | pericentriolar material 1 | 0.031372 |
| PTMS | parathymosin | 0.0312326 |
| SP3 | Sp3 transcription factor | 0.031193 |
| TBK1 | TANK-binding kinase 1 | 0.0311797 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.031161 |
| RPL3 | ribosomal protein L3 | 0.0311531 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.029897 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0295656 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0295165 |
| MSH6 | mutS homolog 6 | 0.0293035 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0289667 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0288361 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0286321 |
| TJP1 | tight junction protein 1 | 0.0284758 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0283063 |
| TPM3 | tropomyosin 3 | 0.027877 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.027701 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.027409 |
| MED13L | mediator complex subunit 13-like | 0.0274024 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.027384 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0273153 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0268846 |
| HELLS | helicase, lymphoid-specific | 0.0264395 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0259916 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0259736 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0259663 |
| ITSN2 | intersectin 2 | 0.0257595 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0254949 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0254672 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0254246 |
| RCOR1 | REST corepressor 1 | 0.0251462 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0248465 |
| CLPTM1L | CLPTM1-like | 0.0247863 |
| EXOC6B | exocyst complex component 6B | 0.0247631 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0245804 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0244208 |
| PNN | pinin, desmosome associated protein | 0.0239899 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0238215 |
| RBMX | RNA binding motif protein, X-linked | 0.023819 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0236858 |
| MSN | moesin | 0.0233439 |
| TUBA1C | tubulin, alpha 1c | 0.0233108 |
| ECT2 | epithelial cell transforming 2 | 0.0231411 |
| RPLP0 | ribosomal protein, large, P0 | 0.0225495 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0224939 |
| NEK7 | NIMA-related kinase 7 | 0.0222091 |
| VCL | vinculin | 0.0221999 |
| SSRP1 | structure specific recognition protein 1 | 0.0220181 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0218874 |
| DIAPH1 | diaphanous-related formin 1 | 0.0217784 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.021527 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0214334 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0214284 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0213423 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0211719 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.2066 |
| PTMA | prothymosin, alpha | -0.10201 |
| RPL35A | ribosomal protein L35a | -0.098663 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0985716 |
| VIM | vimentin | -0.097922 |
| RPLP1 | ribosomal protein, large, P1 | -0.0927802 |
| EHBP1 | EH domain binding protein 1 | -0.083709 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0771112 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0739911 |
| PCDH7 | protocadherin 7 | -0.0705717 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.06714 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0632051 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0615928 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0611819 |
| NLGN1 | neuroligin 1 | -0.0602957 |
| CLDN1 | claudin 1 | -0.0598626 |
| AHNAK | AHNAK nucleoprotein | -0.059842 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0583352 |
| HDLBP | high density lipoprotein binding protein | -0.0576366 |
| ZNF804A | zinc finger protein 804A | -0.055254 |
| SYT1 | synaptotagmin I | -0.0518477 |
| MGAT4C | MGAT4 family, member C | -0.0487447 |
| CANX | calnexin | -0.0477463 |
| RPL38 | ribosomal protein L38 | -0.0473363 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0454444 |
| CCND1 | cyclin D1 | -0.0439894 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0435195 |
| RPL34 | ribosomal protein L34 | -0.0431938 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.042812 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0421242 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0420422 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0400909 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0394866 |
| FTL | ferritin, light polypeptide | -0.0390275 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0381037 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0377644 |
| TPM4 | tropomyosin 4 | -0.0376041 |
| ADIPOR2 | adiponectin receptor 2 | -0.0372396 |
| HMGB1 | high mobility group box 1 | -0.0371869 |
| TMEM123 | transmembrane protein 123 | -0.0365778 |
| RPL12 | ribosomal protein L12 | -0.0358543 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0357502 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0355237 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0352091 |
| EGR1 | early growth response 1 | -0.034827 |
| RPS19 | ribosomal protein S19 | -0.0347526 |
| FUS | FUS RNA binding protein | -0.0347213 |
| NHSL1 | NHS-like 1 | -0.0343746 |
| RASAL2 | RAS protein activator like 2 | -0.034277 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0341169 |
| GNAS | GNAS complex locus | -0.034073 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0339206 |
| HMGA2 | high mobility group AT-hook 2 | -0.0336993 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0336746 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0328882 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0324251 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0323278 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0316807 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.031582 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0313635 |
| NPR2 | natriuretic peptide receptor 2 | -0.0312025 |
| RLF | rearranged L-myc fusion | -0.0308314 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0308093 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.030724 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0306446 |
| SEPTIN7 | septin 7 | -0.0304742 |
| WDR45B | WD repeat domain 45B | -0.0298836 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0297916 |
| RPL19 | ribosomal protein L19 | -0.0297706 |
| YBX1 | Y box binding protein 1 | -0.0296283 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0289682 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0287455 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0283655 |
| RPS27 | ribosomal protein S27 | -0.0283655 |
| GPHN | gephyrin | -0.0279436 |
| EFNA5 | ephrin-A5 | -0.0279002 |
| ANXA2 | annexin A2 | -0.0278626 |
| RPL32 | ribosomal protein L32 | -0.0277139 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0275429 |
| TUBB | tubulin, beta class I | -0.027437 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0273349 |
| RPS20 | ribosomal protein S20 | -0.0271703 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0269278 |
| SQSTM1 | sequestosome 1 | -0.0268714 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0268385 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0266337 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0262886 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0261658 |
| FSTL5 | follistatin-like 5 | -0.0260064 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0259823 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0259448 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0255212 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0253754 |
| RPS29 | ribosomal protein S29 | -0.0253472 |
| UBB | ubiquitin B | -0.0252903 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0252546 |
| HSPB1 | heat shock 27kDa protein 1 | -0.025185 |
| NEBL | nebulette | -0.0251517 |
| PEG10 | paternally expressed 10 | -0.0250965 |
| RPL8 | ribosomal protein L8 | -0.0249867 |
