Ciclopirox_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ciclopirox_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.192141
NALF1 NALCN channel auxiliary factor 1 0.125335
PABPC1 poly(A) binding protein, cytoplasmic 1 0.11486
B2M beta-2-microglobulin 0.110884
LSAMP limbic system-associated membrane protein 0.103034
TPT1 tumor protein, translationally-controlled 1 0.09273
EIF1 eukaryotic translation initiation factor 1 0.0887134
ACTG1 actin gamma 1 0.0839446
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0769016
PDE4D phosphodiesterase 4D, cAMP-specific 0.0724765
VIM vimentin 0.0700743
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0697583
FTL ferritin, light polypeptide 0.0685125
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0672209
FMN1 formin 1 0.0668694
VCL vinculin 0.0660247
GATA3 GATA binding protein 3 0.0640572
MYO6 myosin VI 0.0638925
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0616145
RPL23 ribosomal protein L23 0.0606957
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0606574
RPL35A ribosomal protein L35a 0.0601631
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0590829
RPL19 ribosomal protein L19 0.0581104
ZBTB20 zinc finger and BTB domain containing 20 0.0580476
RPLP0 ribosomal protein, large, P0 0.0563707
RPL37A ribosomal protein L37a 0.0554347
ZSWIM6 zinc finger, SWIM-type containing 6 0.0549901
N4BP2L2 NEDD4 binding protein 2-like 2 0.0536817
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0524306
IGF2 insulin-like growth factor 2 0.0512405
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0507739
PLPP1 phospholipid phosphatase 1 0.0494748
FN1 fibronectin 1 0.0494154
RPLP1 ribosomal protein, large, P1 0.0486357
SIK2 salt-inducible kinase 2 0.0483299
VMP1 vacuole membrane protein 1 0.0479936
TCF12 transcription factor 12 0.0476059
SRRM2 serine/arginine repetitive matrix 2 0.0471259
CCNI cyclin I 0.0467188
MEIS2 Meis homeobox 2 0.0459808
EFNA5 ephrin-A5 0.045592
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0455088
SYT1 synaptotagmin I 0.0453499
RPS12 ribosomal protein S12 0.0446966
RACK1 receptor for activated C kinase 1 0.0431945
RPS23 ribosomal protein S23 0.0426245
DPH6 diphthamine biosynthesis 6 0.0425037
DCAF7 DDB1 and CUL4 associated factor 7 0.0412222
SLC38A2 solute carrier family 38, member 2 0.0411935
CADM2 cell adhesion molecule 2 0.0407064
RPS6 ribosomal protein S6 0.0403569
KLF6 Kruppel-like factor 6 0.0400867
FHIT fragile histidine triad 0.0398793
RHOBTB3 Rho-related BTB domain containing 3 0.0392578
RAD51B RAD51 paralog B 0.039036
DEK DEK proto-oncogene 0.038731
ANTXR1 anthrax toxin receptor 1 0.038451
DIAPH2 diaphanous-related formin 2 0.0380934
RPS8 ribosomal protein S8 0.0379572
RPL7A ribosomal protein L7a 0.0379416
TPM1 tropomyosin 1 (alpha) 0.0377087
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0371918
RPL7 ribosomal protein L7 0.03701
ANGPT1 angiopoietin 1 0.036957
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0369181
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0368684
PRRC2C proline-rich coiled-coil 2C 0.0366001
IFI16 interferon, gamma-inducible protein 16 0.0365188
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.036451
RIGI RNA sensor RIG-I 0.0364317
HLA-A major histocompatibility complex, class I, A 0.0362994
GLCCI1 glucocorticoid induced 1 0.0362622
PRKCA protein kinase C, alpha 0.0360765
CDH13 cadherin 13 0.0360274
ANXA2 annexin A2 0.0359304
EXT1 exostosin glycosyltransferase 1 0.0359303
MT2A metallothionein 2A 0.0356323
RPS29 ribosomal protein S29 0.035576
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0354661
JMJD1C jumonji domain containing 1C 0.0350965
IGFBP3 insulin-like growth factor binding protein 3 0.034778
SLITRK6 SLIT and NTRK-like family, member 6 0.0347113
CBX3 chromobox homolog 3 0.0346454
PTMA prothymosin, alpha 0.0339782
CALD1 caldesmon 1 0.0337864
MCL1 myeloid cell leukemia 1 0.0334612
RNF213 ring finger protein 213 0.0331837
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0328877
KLHL13 kelch-like family member 13 0.0322768
H3-3B H3.3 histone B 0.0321861
S100A9 S100 calcium binding protein A9 0.0319826
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0319056
TENM4 teneurin transmembrane protein 4 0.0318803
IFI6 interferon, alpha-inducible protein 6 0.0318369
CALU calumenin 0.0315753
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0315357
PRKG1 protein kinase, cGMP-dependent, type I 0.0312613
SRSF11 serine/arginine-rich splicing factor 11 0.0312403
PDLIM5 PDZ and LIM domain 5 0.031056

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.108519
HELZ helicase with zinc finger -0.107507
LPIN1 lipin 1 -0.086194
FAM13A family with sequence similarity 13, member A -0.0836928
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0513376
KDM3A lysine (K)-specific demethylase 3A -0.0493713
MYH10 myosin, heavy chain 10, non-muscle -0.0452707
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0444624
CLTC clathrin, heavy chain (Hc) -0.0430754
MYH9 myosin, heavy chain 9, non-muscle -0.0427361
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0415986
COL3A1 collagen, type III, alpha 1 -0.0391651
CASC3 cancer susceptibility candidate 3 -0.0388284
CCNY cyclin Y -0.0375936
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0374965
NPEPPS aminopeptidase puromycin sensitive -0.0373795
MARCHF6 membrane associated ring-CH-type finger 6 -0.0372971
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0368423
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0359373
PEAK1 pseudopodium-enriched atypical kinase 1 -0.035797
OGA O-GlcNAcase -0.0345169
HSPA8 heat shock 70kDa protein 8 -0.0338374
CDC27 cell division cycle 27 -0.0335006
PLAT plasminogen activator, tissue -0.033493
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.033323
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0330268
NREP neuronal regeneration related protein -0.0329078
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.0323422
RPS2 ribosomal protein S2 -0.0321197
EIF4H eukaryotic translation initiation factor 4H -0.031836
PTPRD protein tyrosine phosphatase, receptor type, D -0.0317769
DTNA dystrobrevin, alpha -0.0316493
COL4A2 collagen, type IV, alpha 2 -0.0312783
PICALM phosphatidylinositol binding clathrin assembly protein -0.0308508
GATAD2B GATA zinc finger domain containing 2B -0.0305831
XPO1 exportin 1 -0.0304756
ADAR adenosine deaminase, RNA-specific -0.0303931
H1-4 H1.4 linker histone, cluster member -0.0294441
CEP95 centrosomal protein 95kDa -0.0292079
LMAN1 lectin, mannose-binding, 1 -0.0291132
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0290522
COL4A1 collagen, type IV, alpha 1 -0.0287999
NCAM2 neural cell adhesion molecule 2 -0.0286337
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0284761
PIBF1 progesterone immunomodulatory binding factor 1 -0.0284325
NIPBL Nipped-B homolog (Drosophila) -0.0283691
KMT2C lysine (K)-specific methyltransferase 2C -0.0283458
GPBP1 GC-rich promoter binding protein 1 -0.028324
CDC73 cell division cycle 73 -0.0282272
PHF21A PHD finger protein 21A -0.0281799
ZFAND3 zinc finger, AN1-type domain 3 -0.0281006
CDK12 cyclin-dependent kinase 12 -0.028023
HAND2 heart and neural crest derivatives expressed 2 -0.0279914
GOLGA4 golgin A4 -0.0278858
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0278728
SUCO SUN domain containing ossification factor -0.0276518
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0276237
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0276144
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0274972
TFRC transferrin receptor -0.0274163
ZC3H11A zinc finger CCCH-type containing 11A -0.0271083
NEK7 NIMA-related kinase 7 -0.0270848
SRSF1 serine/arginine-rich splicing factor 1 -0.0268177
CSNK1G1 casein kinase 1, gamma 1 -0.0268133
KIAA1217 KIAA1217 -0.0262005
COL18A1 collagen, type XVIII, alpha 1 -0.0261814
SOS1 son of sevenless homolog 1 (Drosophila) -0.0259233
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0257818
MBTD1 mbt domain containing 1 -0.0256961
LONP2 lon peptidase 2, peroxisomal -0.0255946
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0254913
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0253658
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0253269
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0251637
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0251297
PRPF3 pre-mRNA processing factor 3 -0.0251182
C2ORF42 chromosome 2 open reading frame 42 -0.0249907
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0249379
VGF VGF nerve growth factor inducible -0.0249346
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.0249044
MAP1B microtubule-associated protein 1B -0.024897
SEC24D SEC24 family member D -0.0248655
SRP54 signal recognition particle 54kDa -0.0247506
TENT2 terminal nucleotidyltransferase 2 -0.0247315
SMYD3 SET and MYND domain containing 3 -0.0246546
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0245963
FXR1 fragile X mental retardation, autosomal homolog 1 -0.024535
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.024533
PTK2 protein tyrosine kinase 2 -0.0243395
ARHGAP9 Rho GTPase activating protein 9 -0.0242644
ZMIZ1 zinc finger, MIZ-type containing 1 -0.024247
ZNF37A zinc finger protein 37A -0.0241551
RANBP10 RAN binding protein 10 -0.0241253
RC3H1 ring finger and CCCH-type domains 1 -0.024027
GPC5 glypican 5 -0.0239938
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0239087
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0237645
MXI1 MAX interactor 1, dimerization protein -0.0237341
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0236118
YME1L1 YME1-like 1 ATPase -0.0234195