Ciclopirox_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ciclopirox_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.186292
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.144737
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.122291
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.109042
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0912077
RNF43 ring finger protein 43 0.0837733
DSCAM Down syndrome cell adhesion molecule 0.0832455
IFNGR1 interferon gamma receptor 1 0.0816039
YAP1 Yes-associated protein 1 0.0784647
LCN2 lipocalin 2 0.074148
NCKAP5 NCK-associated protein 5 0.0734424
RUNX1 runt-related transcription factor 1 0.0716758
B2M beta-2-microglobulin 0.0693959
USP54 ubiquitin specific peptidase 54 0.0674796
NRIP1 nuclear receptor interacting protein 1 0.0669169
ASPH aspartate beta-hydroxylase 0.066574
PTBP3 polypyrimidine tract binding protein 3 0.0661637
RHOBTB3 Rho-related BTB domain containing 3 0.065918
ATP10B ATPase, class V, type 10B 0.0656328
SMAD3 SMAD family member 3 0.0641558
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0629895
MLPH melanophilin 0.0629243
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.06213
ZBTB20 zinc finger and BTB domain containing 20 0.0590689
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0582948
SPRED1 sprouty-related, EVH1 domain containing 1 0.0582326
BTBD9 BTB (POZ) domain containing 9 0.0564907
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.056278
LMO7 LIM domain 7 0.0552892
PDZD8 PDZ domain containing 8 0.054926
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0546982
PRSS3 protease, serine, 3 0.0527879
C6ORF132 chromosome 6 open reading frame 132 0.0524591
TMC5 transmembrane channel-like 5 0.0518872
TXNIP thioredoxin interacting protein 0.0511904
ATP11A ATPase, class VI, type 11A 0.0509223
MBNL2 muscleblind-like splicing regulator 2 0.0503889
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0501964
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0492649
MACF1 microtubule-actin crosslinking factor 1 0.0492008
H1-0 H1.0 linker histone 0.0490787
CEMIP2 cell migration inducing hyaluronidase 2 0.0487393
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.048078
EXT1 exostosin glycosyltransferase 1 0.0476109
ZMYND8 zinc finger, MYND-type containing 8 0.0472838
CTNND1 catenin (cadherin-associated protein), delta 1 0.0472481
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0448376
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0445721
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0438643
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0438496
BICRAL BICRA like chromatin remodeling complex associated protein 0.043786
BCL2L1 BCL2-like 1 0.0436539
TJP2 tight junction protein 2 0.0429533
UBAC2 UBA domain containing 2 0.042944
SH3PXD2A SH3 and PX domains 2A 0.042924
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0428074
MYH9 myosin, heavy chain 9, non-muscle 0.042637
TC2N tandem C2 domains, nuclear 0.0425865
DUSP16 dual specificity phosphatase 16 0.0412172
CTBP2 C-terminal binding protein 2 0.0411851
STK24 serine/threonine kinase 24 0.0406787
DST dystonin 0.0405873
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0392072
EPCAM epithelial cell adhesion molecule 0.0386367
CD2AP CD2-associated protein 0.0378313
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0372516
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0371283
ADAM10 ADAM metallopeptidase domain 10 0.0365256
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0362065
MT2A metallothionein 2A 0.0358777
FAT1 FAT atypical cadherin 1 0.0349086
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0348665
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0348567
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0344305
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0339622
NCOR1 nuclear receptor corepressor 1 0.0338919
CDC42SE2 CDC42 small effector 2 0.0332753
NT5C2 5'-nucleotidase, cytosolic II 0.0330923
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0330788
KIAA1217 KIAA1217 0.0323879
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0321369
AOPEP aminopeptidase O (putative) 0.0320658
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0317425
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0316191
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0315251
FMN1 formin 1 0.0308651
ARGLU1 arginine and glutamate rich 1 0.0307372
SPRED2 sprouty-related, EVH1 domain containing 2 0.0306498
SACK1B scaffolding CK1 anchoring protein B 0.0305982
RPL7L1 ribosomal protein L7-like 1 0.030463
SH3RF1 SH3 domain containing ring finger 1 0.0302117
RNF149 ring finger protein 149 0.0301347
EFNB2 ephrin-B2 0.0299361
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0298579
NIBAN2 niban apoptosis regulator 2 0.0298054
CERS6 ceramide synthase 6 0.0297474
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0297234
TOX3 TOX high mobility group box family member 3 0.0296128
ARHGAP32 Rho GTPase activating protein 32 0.0294737
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0290793

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.127673
LYZ lysozyme -0.113131
NPSR1 neuropeptide S receptor 1 -0.0853532
PTMA prothymosin, alpha -0.0852781
RAB7A RAB7A, member RAS oncogene family -0.0787446
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0654874
LOC102724023 ES1 protein homolog, mitochondrial -0.0570335
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0570192
RSAD2 radical S-adenosyl methionine domain containing 2 -0.053906
SP100 SP100 nuclear antigen -0.0511365
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0501591
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0496022
TJP1 tight junction protein 1 -0.048127
MX1 MX dynamin-like GTPase 1 -0.0475634
EZR ezrin -0.044414
RIGI RNA sensor RIG-I -0.043776
JUN jun proto-oncogene -0.0412309
TMSB10 thymosin beta 10 -0.040753
FTH1 ferritin, heavy polypeptide 1 -0.0404856
MX2 MX dynamin-like GTPase 2 -0.0401191
POTEF POTE ankyrin domain family, member F -0.0391745
TM4SF19 transmembrane 4 L six family member 19 -0.0388416
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0385886
BLZF1 basic leucine zipper nuclear factor 1 -0.0385223
PLSCR2 phospholipid scramblase 2 -0.0382
IFIH1 interferon induced with helicase C domain 1 -0.0371808
TSHZ2 teashirt zinc finger homeobox 2 -0.036737
LAMA4 laminin, alpha 4 -0.03553
ANXA2 annexin A2 -0.0354555
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0352181
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0338294
RNF213 ring finger protein 213 -0.0325265
SQSTM1 sequestosome 1 -0.0314525
PERP PERP, TP53 apoptosis effector -0.0313352
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0299241
ACTG1 actin gamma 1 -0.0289238
RPL35A ribosomal protein L35a -0.0286403
MCL1 myeloid cell leukemia 1 -0.02742
HMGB1 high mobility group box 1 -0.0266428
AREG amphiregulin -0.0263567
SIK3 SIK family kinase 3 -0.0260265
OXSR1 oxidative stress responsive 1 -0.0258362
S100A6 S100 calcium binding protein A6 -0.0250529
PLIN2 perilipin 2 -0.0249447
FOSL1 FOS-like antigen 1 -0.0247478
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0243511
HLA-E major histocompatibility complex, class I, E -0.0240759
ITPKC inositol-trisphosphate 3-kinase C -0.0236432
EPSTI1 epithelial stromal interaction 1 (breast) -0.0232872
KPNB1 karyopherin (importin) beta 1 -0.0230229
KRT19 keratin 19, type I -0.023001
FBXO39 F-box protein 39 -0.0229443
HLA-B major histocompatibility complex, class I, B -0.022855
IFI27 interferon, alpha-inducible protein 27 -0.0224831
ZNF165 zinc finger protein 165 -0.0222818
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0222525
PLSCR1 phospholipid scramblase 1 -0.0221335
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0214985
ERBIN erbb2 interacting protein -0.021403
GMDS GDP-mannose 4,6-dehydratase -0.0213862
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0211855
GK glycerol kinase -0.0210717
SDC4 syndecan 4 -0.0206716
NCEH1 neutral cholesterol ester hydrolase 1 -0.0206594
EFHD2 EF-hand domain family, member D2 -0.0203897
DDIT3 DNA-damage-inducible transcript 3 -0.0203079
SETX senataxin -0.0201448
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0201408
DEK DEK proto-oncogene -0.0195646
UBAP2 ubiquitin associated protein 2 -0.0194753
PMP22 peripheral myelin protein 22 -0.0194745
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0194663
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0194617
SMC4 structural maintenance of chromosomes 4 -0.0189348
IFITM3 interferon induced transmembrane protein 3 -0.0188647
GNAS GNAS complex locus -0.0187568
ADM adrenomedullin -0.0187134
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0187109
MAML2 mastermind-like 2 (Drosophila) -0.0186382
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0185768
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0184838
FA2H fatty acid 2-hydroxylase -0.0183162
MAGT1 magnesium transporter 1 -0.0181137
SEC31A SEC31 homolog A (S. cerevisiae) -0.0180588
IER3 immediate early response 3 -0.0179684
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0178868
ZHX2 zinc fingers and homeoboxes 2 -0.0178036
NABP1 nucleic acid binding protein 1 -0.0176992
GOSR2 golgi SNAP receptor complex member 2 -0.0176681
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0175678
CLDN7 claudin 7 -0.017453
IRF1 interferon regulatory factor 1 -0.0172439
IGBP1 immunoglobulin (CD79A) binding protein 1 -0.0170633
KRT18 keratin 18, type I -0.0170442
ATF4 activating transcription factor 4 -0.0169293
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0167185
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0166178
SPDYA speedy/RINGO cell cycle regulator family member A -0.01651
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0164184
PDIA3 protein disulfide isomerase family A, member 3 -0.0163042