Ciclopirox_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ciclopirox_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.339199
COL6A3 collagen, type VI, alpha 3 0.205727
CDH13 cadherin 13 0.159353
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.112352
ASPH aspartate beta-hydroxylase 0.110446
EXT1 exostosin glycosyltransferase 1 0.0883847
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0817112
FNDC3B fibronectin type III domain containing 3B 0.0635517
CD44 CD44 molecule (Indian blood group) 0.0614698
NAV1 neuron navigator 1 0.0583611
PSD3 pleckstrin and Sec7 domain containing 3 0.0570935
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.056206
GLIS3 GLIS family zinc finger 3 0.0542087
CALD1 caldesmon 1 0.0529218
MBNL1 muscleblind-like splicing regulator 1 0.049071
LTBP1 latent transforming growth factor beta binding protein 1 0.048882
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0481768
TGFBI transforming growth factor, beta-induced, 68kDa 0.0476396
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0465099
NDRG1 N-myc downstream regulated 1 0.0441293
LPP LIM domain containing preferred translocation partner in lipoma 0.0438789
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0438276
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0434786
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0434724
DST dystonin 0.0427589
PDLIM5 PDZ and LIM domain 5 0.0425741
LOX lysyl oxidase 0.0420741
CXCL8 chemokine (C-X-C motif) ligand 8 0.0410316
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0409553
NALF1 NALCN channel auxiliary factor 1 0.0404729
VCL vinculin 0.0404488
SDC2 syndecan 2 0.0401622
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0392565
IL6ST interleukin 6 signal transducer 0.038347
MAP1B microtubule-associated protein 1B 0.0374748
DPYD dihydropyrimidine dehydrogenase 0.037375
JARID2 jumonji, AT rich interactive domain 2 0.0366902
DOCK5 dedicator of cytokinesis 5 0.0360748
MSN moesin 0.0340633
CNTN5 contactin 5 0.0339345
ADAM12 ADAM metallopeptidase domain 12 0.0330699
SLC38A2 solute carrier family 38, member 2 0.0329777
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0329477
EGFR epidermal growth factor receptor 0.0322044
COL5A1 collagen, type V, alpha 1 0.0321796
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0315172
HDAC9 histone deacetylase 9 0.0314879
COL6A1 collagen, type VI, alpha 1 0.0312153
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.030794
HIPK2 homeodomain interacting protein kinase 2 0.0306459
PICALM phosphatidylinositol binding clathrin assembly protein 0.0303937
ATXN1 ataxin 1 0.0299609
CPQ carboxypeptidase Q 0.0289379
WWTR1 WW domain containing transcription regulator 1 0.0284196
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0283986
FOXP1 forkhead box P1 0.0279667
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0278349
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0271912
ERRFI1 ERBB receptor feedback inhibitor 1 0.0271278
MYO10 myosin X 0.0267755
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.026459
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0264254
TRPS1 trichorhinophalangeal syndrome I 0.0263253
PTPRG protein tyrosine phosphatase, receptor type, G 0.0261732
ZFPM2 zinc finger protein, FOG family member 2 0.0260583
IFI6 interferon, alpha-inducible protein 6 0.0252034
PDE4D phosphodiesterase 4D, cAMP-specific 0.0251076
HMGA2 high mobility group AT-hook 2 0.025039
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0249868
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0248618
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0247683
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0243706
OSMR oncostatin M receptor 0.0237509
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0237285
ANKRD28 ankyrin repeat domain 28 0.0234954
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0234845
CD59 CD59 molecule, complement regulatory protein 0.0234374
HLA-A major histocompatibility complex, class I, A 0.0232186
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0232018
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0226428
VEGFA vascular endothelial growth factor A 0.0221186
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0220123
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0219898
OXR1 oxidation resistance 1 0.0216839
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0215727
ZSWIM6 zinc finger, SWIM-type containing 6 0.0213932
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0210136
NRP1 neuropilin 1 0.0209304
HLA-B major histocompatibility complex, class I, B 0.0207747
PDIA5 protein disulfide isomerase family A, member 5 0.0204556
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.020376
ZEB1 zinc finger E-box binding homeobox 1 0.0202362
SON SON DNA binding protein 0.0200141
MED13L mediator complex subunit 13-like 0.0199993
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0199855
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0198788
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198555
PRKN parkin RBR E3 ubiquitin protein ligase 0.0198323
NAV2 neuron navigator 2 0.0197637
SLC25A51 solute carrier family 25, member 51 0.0196754

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.404552
VIM vimentin -0.141464
FN1 fibronectin 1 -0.128486
PTMA prothymosin, alpha -0.0951583
TMSB10 thymosin beta 10 -0.0894625
IER3 immediate early response 3 -0.0881289
FTL ferritin, light polypeptide -0.0757347
NAMPT nicotinamide phosphoribosyltransferase -0.0674602
MT2A metallothionein 2A -0.0653105
RPS8 ribosomal protein S8 -0.0613673
TPM4 tropomyosin 4 -0.0600401
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0582008
RPL35A ribosomal protein L35a -0.0564371
ICAM1 intercellular adhesion molecule 1 -0.0556242
BHLHE40 basic helix-loop-helix family, member e40 -0.0522766
RPS6 ribosomal protein S6 -0.0479304
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0463585
RLF rearranged L-myc fusion -0.0459913
TM4SF1 transmembrane 4 L six family member 1 -0.0456755
EIF1 eukaryotic translation initiation factor 1 -0.0448026
GOLGA4 golgin A4 -0.0406777
TRIO trio Rho guanine nucleotide exchange factor -0.0405718
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0402594
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0402344
YBX1 Y box binding protein 1 -0.0391726
WSB1 WD repeat and SOCS box containing 1 -0.038262
ZNF292 zinc finger protein 292 -0.0382192
COL3A1 collagen, type III, alpha 1 -0.038032
FTH1 ferritin, heavy polypeptide 1 -0.0350275
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0344513
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.034072
TFRC transferrin receptor -0.0340525
EEF2 eukaryotic translation elongation factor 2 -0.0338509
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0335168
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0327765
GNAS GNAS complex locus -0.0324027
RPS19 ribosomal protein S19 -0.0316065
SPAG9 sperm associated antigen 9 -0.0315402
ANXA2 annexin A2 -0.0310581
MT1X metallothionein 1X -0.0308908
RPL8 ribosomal protein L8 -0.0308418
MYO9B myosin IXB -0.0298706
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0289719
RPL34 ribosomal protein L34 -0.0286829
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0279632
SQLE squalene epoxidase -0.0279352
RPLP1 ribosomal protein, large, P1 -0.0277567
TFG TRK-fused gene -0.0274444
RPS3 ribosomal protein S3 -0.0273337
RRBP1 ribosome binding protein 1 -0.0271164
USP3 ubiquitin specific peptidase 3 -0.0271146
POSTN periostin, osteoblast specific factor -0.0271141
LMAN1 lectin, mannose-binding, 1 -0.026858
TMSB4X thymosin beta 4, X-linked -0.0265967
RPL32 ribosomal protein L32 -0.0265222
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0264492
CAVIN1 caveolae associated protein 1 -0.0261477
RPL23 ribosomal protein L23 -0.0260216
LOC112694756 uncharaterized LOC112694756 -0.0260073
RPL19 ribosomal protein L19 -0.0259457
ATP13A3 ATPase type 13A3 -0.0257728
MATR3 matrin 3 -0.0257646
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0255209
FMNL2 formin-like 2 -0.025236
RPL26 ribosomal protein L26 -0.0252076
RPL13A ribosomal protein L13a -0.0251624
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0248029
RPL36 ribosomal protein L36 -0.0246259
RPL28 ribosomal protein L28 -0.0245277
RAB1A RAB1A, member RAS oncogene family -0.0244947
WDR45B WD repeat domain 45B -0.0243215
RNF24 ring finger protein 24 -0.0242353
SRGN serglycin -0.0238646
RPS24 ribosomal protein S24 -0.0234664
RPL12 ribosomal protein L12 -0.023352
HLA-E major histocompatibility complex, class I, E -0.0230041
RPLP2 ribosomal protein, large, P2 -0.0229775
VDAC1 voltage-dependent anion channel 1 -0.0228204
RPL5 ribosomal protein L5 -0.0227238
DDIT4 DNA-damage-inducible transcript 4 -0.0225911
TKT transketolase -0.0223991
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0223029
MARCHF6 membrane associated ring-CH-type finger 6 -0.0222748
SKIC3 SKI3 subunit of superkiller complex -0.021976
HDLBP high density lipoprotein binding protein -0.0217597
MAP4 microtubule-associated protein 4 -0.0216758
CANX calnexin -0.0216574
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0216517
PRRC1 proline-rich coiled-coil 1 -0.0215748
CAMTA1 calmodulin binding transcription activator 1 -0.021399
RBM39 RNA binding motif protein 39 -0.0213226
DLG1 discs, large homolog 1 (Drosophila) -0.0212024
ADM adrenomedullin -0.020886
RPS16 ribosomal protein S16 -0.0208157
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0205939
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.020389
RAD21 RAD21 homolog (S. pombe) -0.0201822
QKI QKI, KH domain containing, RNA binding -0.0200597
CFDP1 craniofacial development protein 1 -0.0199965
SDC4 syndecan 4 -0.0197317