Ciclopirox_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ciclopirox_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.251079
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.183002
TPT1 tumor protein, translationally-controlled 1 0.138714
RPL11 ribosomal protein L11 0.130951
ERRFI1 ERBB receptor feedback inhibitor 1 0.083698
SLC38A2 solute carrier family 38, member 2 0.080204
MT2A metallothionein 2A 0.0780358
RPL23 ribosomal protein L23 0.0750823
ITGAV integrin, alpha V 0.0732123
BCL2L1 BCL2-like 1 0.070446
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0688265
NRIP1 nuclear receptor interacting protein 1 0.0677762
RPS24 ribosomal protein S24 0.0660259
RPS12 ribosomal protein S12 0.0651187
NKD1 naked cuticle homolog 1 (Drosophila) 0.0648211
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0643888
RPS21 ribosomal protein S21 0.0616245
MRTFA myocardin related transcription factor A 0.0610455
DSPP dentin sialophosphoprotein 0.059558
RPS6 ribosomal protein S6 0.0565231
HMGA1 high mobility group AT-hook 1 0.0549452
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0548824
RPL5 ribosomal protein L5 0.0538641
FAM107B family with sequence similarity 107, member B 0.053769
PAWR PRKC, apoptosis, WT1, regulator 0.0531367
NAP1L1 nucleosome assembly protein 1-like 1 0.0506524
ATXN1 ataxin 1 0.0506418
ZFAND3 zinc finger, AN1-type domain 3 0.0497409
MACF1 microtubule-actin crosslinking factor 1 0.0496767
RPL31 ribosomal protein L31 0.0491091
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0482696
FOXP1 forkhead box P1 0.0482423
ITCH itchy E3 ubiquitin protein ligase 0.047961
SPTBN1 spectrin, beta, non-erythrocytic 1 0.04645
ARHGAP9 Rho GTPase activating protein 9 0.0464228
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0463881
RPS27A ribosomal protein S27a 0.0463695
RPL9 ribosomal protein L9 0.045151
EPS8 epidermal growth factor receptor pathway substrate 8 0.0448743
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0442916
RPL37A ribosomal protein L37a 0.0432437
PDLIM5 PDZ and LIM domain 5 0.0430625
FRMD5 FERM domain containing 5 0.0425748
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0424255
RPS3 ribosomal protein S3 0.0423798
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0420243
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0415262
FN1 fibronectin 1 0.0412184
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0409458
GPC3 glypican 3 0.0403935
BCAR3 breast cancer anti-estrogen resistance 3 0.0398252
KIF21A kinesin family member 21A 0.0397275
LCOR ligand dependent nuclear receptor corepressor 0.0384473
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0381077
SMAD3 SMAD family member 3 0.037453
SH3RF1 SH3 domain containing ring finger 1 0.036698
SESTD1 SEC14 and spectrin domains 1 0.0362671
RPS14 ribosomal protein S14 0.0361736
USP34 ubiquitin specific peptidase 34 0.0359467
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0356276
INTS6 integrator complex subunit 6 0.0352059
RPS8 ribosomal protein S8 0.0349903
RPLP2 ribosomal protein, large, P2 0.0348445
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0345002
RPL26 ribosomal protein L26 0.0343902
SAMD4A sterile alpha motif domain containing 4A 0.0341765
WWTR1 WW domain containing transcription regulator 1 0.0340428
AFDN afadin, adherens junction formation factor 0.0336329
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0333133
UBASH3B ubiquitin associated and SH3 domain containing B 0.0332034
LIMS1 LIM and senescent cell antigen-like domains 1 0.0328087
PTPRM protein tyrosine phosphatase, receptor type, M 0.0326134
RPL36A ribosomal protein L36a 0.0323448
RPS15 ribosomal protein S15 0.0322538
ARHGAP26 Rho GTPase activating protein 26 0.0316496
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0313182
FOXO1 forkhead box O1 0.0309858
TM4SF1 transmembrane 4 L six family member 1 0.0307629
JAG1 jagged 1 0.0306332
SPRED2 sprouty-related, EVH1 domain containing 2 0.0302234
RASA2 RAS p21 protein activator 2 0.030213
APOE apolipoprotein E 0.0301684
KIF1B kinesin family member 1B 0.0298187
MYH9 myosin, heavy chain 9, non-muscle 0.0294771
MYO5B myosin VB 0.0294425
TLE4 transducin-like enhancer of split 4 0.0293844
RPL30 ribosomal protein L30 0.0293242
MYO6 myosin VI 0.0293132
RPS10 ribosomal protein S10 0.02921
NACA nascent polypeptide-associated complex alpha subunit 0.0284059
RPS23 ribosomal protein S23 0.0280564
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0276673
RPL37 ribosomal protein L37 0.0275697
CTNND1 catenin (cadherin-associated protein), delta 1 0.0275207
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0275134
RPL12 ribosomal protein L12 0.0274516
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0273099
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0272979
S100A9 S100 calcium binding protein A9 0.0272663
RACK1 receptor for activated C kinase 1 0.0272651

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.211418
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.158029
PEG3 paternally expressed 3 -0.0660127
DDIT4 DNA-damage-inducible transcript 4 -0.0611753
ELL2 elongation factor, RNA polymerase II, 2 -0.057389
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0525047
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0521122
EHBP1 EH domain binding protein 1 -0.049207
GK glycerol kinase -0.0483369
CP ceruloplasmin (ferroxidase) -0.0469741
ZMYND8 zinc finger, MYND-type containing 8 -0.0458423
TPM4 tropomyosin 4 -0.0449019
ATP10A ATPase, class V, type 10A -0.0405338
BHLHE40 basic helix-loop-helix family, member e40 -0.0398697
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0364708
AKAP12 A kinase (PRKA) anchor protein 12 -0.0354783
PLIN2 perilipin 2 -0.0354572
JUN jun proto-oncogene -0.0341698
DTNA dystrobrevin, alpha -0.0324433
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0320893
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0316904
RNF24 ring finger protein 24 -0.0295748
LMCD1 LIM and cysteine-rich domains 1 -0.0285985
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0281496
RNF213 ring finger protein 213 -0.0279614
LOC112694756 uncharaterized LOC112694756 -0.027961
KIAA1217 KIAA1217 -0.0276183
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0266388
ATF3 activating transcription factor 3 -0.0263833
RIGI RNA sensor RIG-I -0.0261255
WDR45B WD repeat domain 45B -0.0261229
ESYT2 extended synaptotagmin-like protein 2 -0.0259927
CANX calnexin -0.0259552
OSMR oncostatin M receptor -0.0257862
GPC6 glypican 6 -0.0256855
MX2 MX dynamin-like GTPase 2 -0.025515
KRT23 keratin 23, type I -0.0254894
SYNE1 spectrin repeat containing, nuclear envelope 1 -0.025157
PKM pyruvate kinase, muscle -0.0249983
NAMPT nicotinamide phosphoribosyltransferase -0.0249047
ENO1 enolase 1, (alpha) -0.0245813
JMJD1C jumonji domain containing 1C -0.0244518
DENND5B DENN/MADD domain containing 5B -0.0236522
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0236501
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0235729
TCIM transcriptional and immune response regulator -0.0232918
HELZ helicase with zinc finger -0.0226845
FAM13A family with sequence similarity 13, member A -0.0224081
EGR1 early growth response 1 -0.0221996
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0221066
DNAH17 dynein, axonemal, heavy chain 17 -0.0220374
AHNAK AHNAK nucleoprotein -0.0217907
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0217734
PDIA3 protein disulfide isomerase family A, member 3 -0.0214775
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.021345
LMAN1 lectin, mannose-binding, 1 -0.0213072
CCL20 chemokine (C-C motif) ligand 20 -0.0212944
MAML2 mastermind-like 2 (Drosophila) -0.0212395
AFF4 AF4/FMR2 family, member 4 -0.0209763
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0208675
LAMA4 laminin, alpha 4 -0.0206991
MSI2 musashi RNA-binding protein 2 -0.0206458
RSRC2 arginine/serine-rich coiled-coil 2 -0.0205792
ICAM1 intercellular adhesion molecule 1 -0.020326
TBCK TBC1 domain containing kinase -0.0201205
MAP4 microtubule-associated protein 4 -0.0199384
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0199197
UBXN4 UBX domain protein 4 -0.0198139
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0196192
FTH1 ferritin, heavy polypeptide 1 -0.0191887
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.019131
PDIA6 protein disulfide isomerase family A, member 6 -0.0191241
KPNB1 karyopherin (importin) beta 1 -0.0191144
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0190047
FBF1 Fas (TNFRSF6) binding factor 1 -0.0189789
KIZ kizuna centrosomal protein -0.0187796
SREBF2 sterol regulatory element binding transcription factor 2 -0.0186195
SAMHD1 SAM domain and HD domain 1 -0.0183838
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0183337
DARS1 aspartyl-tRNA synthetase 1 -0.018133
GNAS GNAS complex locus -0.0180953
FNDC3B fibronectin type III domain containing 3B -0.0180241
SYBU syntabulin (syntaxin-interacting) -0.0179594
RREB1 ras responsive element binding protein 1 -0.017896
FAM117B family with sequence similarity 117, member B -0.0178717
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0177765
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0176128
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0175657
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0174929
IFIH1 interferon induced with helicase C domain 1 -0.0173513
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0172633
ENKUR enkurin, TRPC channel interacting protein -0.017236
ZNF644 zinc finger protein 644 -0.017234
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0170202
PER2 period circadian clock 2 -0.0169452
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0169014
RUNX1 runt-related transcription factor 1 -0.0168551
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0167972
KCMF1 potassium channel modulatory factor 1 -0.0165358
SARAF store-operated calcium entry-associated regulatory factor -0.0165212