Ciclopirox_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ciclopirox_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.14646
MSN moesin 0.117786
PALM2AKAP2 PALM2 and AKAP2 fusion 0.103024
FOXO1 forkhead box O1 0.0943244
FLNB filamin B, beta 0.0942513
BCAR3 breast cancer anti-estrogen resistance 3 0.0939041
DOK5 docking protein 5 0.0722293
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0710499
MT2A metallothionein 2A 0.0710342
MYH9 myosin, heavy chain 9, non-muscle 0.0668298
TGM2 transglutaminase 2 0.0651336
MBNL1 muscleblind-like splicing regulator 1 0.0600153
BCL2L1 BCL2-like 1 0.0591953
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0584571
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0584492
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0536377
CLU clusterin 0.0522444
KTN1 kinectin 1 (kinesin receptor) 0.0508016
HLA-B major histocompatibility complex, class I, B 0.050397
PICALM phosphatidylinositol binding clathrin assembly protein 0.0492021
MEF2A myocyte enhancer factor 2A 0.0489566
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0487971
SEPTIN9 septin 9 0.0485534
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0483853
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0469058
SLK STE20-like kinase 0.0467027
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.045493
MCL1 myeloid cell leukemia 1 0.044582
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0441765
SULF1 sulfatase 1 0.0431757
IFITM1 interferon induced transmembrane protein 1 0.0426656
PCDH1 protocadherin 1 0.0421921
IFI44L interferon-induced protein 44-like 0.0420074
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0417029
RPS13 ribosomal protein S13 0.0415712
FOSL1 FOS-like antigen 1 0.0408092
S100A9 S100 calcium binding protein A9 0.0406889
MT1E metallothionein 1E 0.0401495
EFNA5 ephrin-A5 0.0396784
TSC22D1 TSC22 domain family, member 1 0.0392035
RICTOR RPTOR independent companion of MTOR, complex 2 0.0391824
ACTN4 actinin, alpha 4 0.037968
RPL11 ribosomal protein L11 0.0372526
RPL23 ribosomal protein L23 0.0367363
ECE1 endothelin converting enzyme 1 0.0366773
LUZP1 leucine zipper protein 1 0.0365764
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0363444
GRB10 growth factor receptor-bound protein 10 0.0363383
PLEC plectin 0.0359825
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0357512
APLP2 amyloid beta (A4) precursor-like protein 2 0.0357108
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0355392
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0350781
WARS1 tryptophanyl-tRNA synthetase 1 0.0348534
SMAD3 SMAD family member 3 0.0343675
PLAT plasminogen activator, tissue 0.0341468
CSTB cystatin B (stefin B) 0.0340373
AKAP13 A kinase (PRKA) anchor protein 13 0.0340234
TXNIP thioredoxin interacting protein 0.0339833
NIBAN2 niban apoptosis regulator 2 0.0339412
CAPRIN2 caprin family member 2 0.0338959
IFI6 interferon, alpha-inducible protein 6 0.0336307
FNDC3A fibronectin type III domain containing 3A 0.0332867
RPL36A ribosomal protein L36a 0.0332187
CAPN2 calpain 2, (m/II) large subunit 0.0331344
ATXN1 ataxin 1 0.0321787
NCOR2 nuclear receptor corepressor 2 0.0320424
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0317069
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0316688
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0315375
BLCAP bladder cancer associated protein 0.0313454
CTNND1 catenin (cadherin-associated protein), delta 1 0.0309571
SRPK2 SRSF protein kinase 2 0.0308338
MDK midkine (neurite growth-promoting factor 2) 0.0308018
IFI27 interferon, alpha-inducible protein 27 0.0304271
ITGAV integrin, alpha V 0.0303276
SOX13 SRY (sex determining region Y)-box 13 0.0302787
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0300528
LAMA5 laminin, alpha 5 0.030028
HIPK3 homeodomain interacting protein kinase 3 0.0292903
HSPG2 heparan sulfate proteoglycan 2 0.0288545
RAB10 RAB10, member RAS oncogene family 0.0287071
RIGI RNA sensor RIG-I 0.028654
VCL vinculin 0.0281832
RPS21 ribosomal protein S21 0.0279421
AMOTL1 angiomotin like 1 0.0278778
N4BP2L2 NEDD4 binding protein 2-like 2 0.0277575
UBC ubiquitin C 0.0276792
PDE4D phosphodiesterase 4D, cAMP-specific 0.0276204
DSTN destrin (actin depolymerizing factor) 0.0276178
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.02742
WAC WW domain containing adaptor with coiled-coil 0.0271824
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0271812
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0270558
TRIP12 thyroid hormone receptor interactor 12 0.0270255
KDM6A lysine (K)-specific demethylase 6A 0.0268897
TJP1 tight junction protein 1 0.0268886
EFNB2 ephrin-B2 0.0267561
MPRIP myosin phosphatase Rho interacting protein 0.0267433
EHBP1L1 EH domain binding protein 1-like 1 0.0266787

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.289603
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.180818
AHNAK AHNAK nucleoprotein -0.0706764
ANXA1 annexin A1 -0.0622145
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0577551
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0526037
PTMA prothymosin, alpha -0.0510518
MKI67 marker of proliferation Ki-67 -0.0505465
RBM39 RNA binding motif protein 39 -0.0455264
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0434472
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0428345
ALCAM activated leukocyte cell adhesion molecule -0.0392302
TMSB4X thymosin beta 4, X-linked -0.0385572
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0379807
VDAC1 voltage-dependent anion channel 1 -0.036233
CANX calnexin -0.0357488
RRBP1 ribosome binding protein 1 -0.0349684
ENO1 enolase 1, (alpha) -0.0346238
GNAS GNAS complex locus -0.0343161
OGA O-GlcNAcase -0.0335077
ANXA2 annexin A2 -0.0332262
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0324861
MORF4L2 mortality factor 4 like 2 -0.0323973
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0318438
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0313822
KDM3A lysine (K)-specific demethylase 3A -0.0312461
GOLGA4 golgin A4 -0.0309803
ARF1 ADP-ribosylation factor 1 -0.030562
HDLBP high density lipoprotein binding protein -0.0302486
KRT17 keratin 17, type I -0.0302262
HSPH1 heat shock 105kDa/110kDa protein 1 -0.030165
IARS1 isoleucyl-tRNA synthetase 1 -0.029687
GOLGB1 golgin B1 -0.0285662
ABI3BP ABI family, member 3 (NESH) binding protein -0.028302
ZMYND8 zinc finger, MYND-type containing 8 -0.0271797
TMSB10 thymosin beta 10 -0.0270771
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0270558
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0270201
RAB7A RAB7A, member RAS oncogene family -0.0268741
ANLN anillin, actin binding protein -0.0268595
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0265526
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0261282
C4BPB complement component 4 binding protein, beta -0.0259169
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0251104
CALU calumenin -0.025067
THBD thrombomodulin -0.0241832
LAMB3 laminin, beta 3 -0.0234344
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0232849
RAB1A RAB1A, member RAS oncogene family -0.0231452
NAMPT nicotinamide phosphoribosyltransferase -0.0229913
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0229691
FNIP1 folliculin interacting protein 1 -0.0225681
RAI14 retinoic acid induced 14 -0.0222974
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0221856
GLG1 golgi glycoprotein 1 -0.0221852
RPLP1 ribosomal protein, large, P1 -0.022059
S100A2 S100 calcium binding protein A2 -0.0213672
RPL12 ribosomal protein L12 -0.0213251
MBNL2 muscleblind-like splicing regulator 2 -0.0208033
CLDN1 claudin 1 -0.0207198
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0205432
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0204782
SEPTIN2 septin 2 -0.0203813
TAS2R14 taste receptor, type 2, member 14 -0.0202691
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0201337
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0200492
DPYD dihydropyrimidine dehydrogenase -0.020018
ACTG1 actin gamma 1 -0.0199795
HMGB1 high mobility group box 1 -0.0199296
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -0.0199064
COPB1 coatomer protein complex, subunit beta 1 -0.0198803
BIRC2 baculoviral IAP repeat containing 2 -0.0197488
PRRC1 proline-rich coiled-coil 1 -0.0196347
LMAN1 lectin, mannose-binding, 1 -0.0196104
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0195282
TMEM263 transmembrane protein 263 -0.0195242
UFM1 ubiquitin-fold modifier 1 -0.0194577
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0194548
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0193198
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0192921
IFI16 interferon, gamma-inducible protein 16 -0.0192684
ZMYM2 zinc finger, MYM-type 2 -0.01903
RAD21 RAD21 homolog (S. pombe) -0.018972
ZEB1 zinc finger E-box binding homeobox 1 -0.0188379
CMIP c-Maf inducing protein -0.01875
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0185579
RPL35A ribosomal protein L35a -0.0184317
TMF1 TATA element modulatory factor 1 -0.018199
PIBF1 progesterone immunomodulatory binding factor 1 -0.0181977
EMP1 epithelial membrane protein 1 -0.0181196
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0175928
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0175024
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -0.0174684
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0171092
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0170203
SRP72 signal recognition particle 72kDa -0.0168681
PDGFB platelet-derived growth factor beta polypeptide -0.0168624
HMBOX1 homeobox containing 1 -0.0167457
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.016639
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0164499