| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ciclopirox perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ciclopirox_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.201071 |
| MT2A | metallothionein 2A | 0.188932 |
| CAPRIN2 | caprin family member 2 | 0.126386 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0901486 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0841531 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0822216 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0763971 |
| TXNRD1 | thioredoxin reductase 1 | 0.074685 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.074616 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0738352 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.068485 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0661678 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.062754 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0618415 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0607832 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0604703 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0552607 |
| UBC | ubiquitin C | 0.0487497 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0442791 |
| VMP1 | vacuole membrane protein 1 | 0.0400383 |
| MT1E | metallothionein 1E | 0.0399011 |
| AREG | amphiregulin | 0.0398751 |
| RPL23 | ribosomal protein L23 | 0.0394618 |
| S100A6 | S100 calcium binding protein A6 | 0.0392551 |
| DST | dystonin | 0.0387961 |
| PYGL | phosphorylase, glycogen, liver | 0.0386757 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0377669 |
| TMEM41B | transmembrane protein 41B | 0.0360204 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0353528 |
| RPL36A | ribosomal protein L36a | 0.0350977 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0350716 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0345184 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0337861 |
| ANGPTL4 | angiopoietin-like 4 | 0.0320589 |
| RPS12 | ribosomal protein S12 | 0.032045 |
| HMGA1 | high mobility group AT-hook 1 | 0.0319667 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.030528 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0303141 |
| EMP1 | epithelial membrane protein 1 | 0.0302926 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0296297 |
| USP12 | ubiquitin specific peptidase 12 | 0.0286465 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0284628 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0281936 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0280624 |
| RTN4 | reticulon 4 | 0.0280093 |
| F2R | coagulation factor II (thrombin) receptor | 0.0275979 |
| MT1X | metallothionein 1X | 0.0275414 |
| MSN | moesin | 0.0272574 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.0269772 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0265888 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.0261626 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0261134 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0258548 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.02522 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0248501 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0246635 |
| ERCC1 | excision repair cross-complementation group 1 | 0.0244528 |
| RPL37 | ribosomal protein L37 | 0.0243577 |
| SFPQ | splicing factor proline/glutamine-rich | 0.024314 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0240252 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0238565 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0237417 |
| EREG | epiregulin | 0.0236831 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0233874 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0233748 |
| MCL1 | myeloid cell leukemia 1 | 0.023355 |
| ACTN1 | actinin, alpha 1 | 0.0232896 |
| RPS23 | ribosomal protein S23 | 0.0232252 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0232221 |
| DNER | delta/notch-like EGF repeat containing | 0.0230183 |
| SVIL | supervillin | 0.0229891 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0229581 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.022785 |
| RPL36 | ribosomal protein L36 | 0.0227047 |
| CDCP1 | CUB domain containing protein 1 | 0.0220987 |
| RTTN | rotatin | 0.0217549 |
| RPS17 | ribosomal protein S17 | 0.0216721 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0215335 |
| RPS10 | ribosomal protein S10 | 0.0214929 |
| RPL28 | ribosomal protein L28 | 0.0207883 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0202037 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0201678 |
| DENND5A | DENN/MADD domain containing 5A | 0.020162 |
| PYGB | phosphorylase, glycogen; brain | 0.0201403 |
| IL6ST | interleukin 6 signal transducer | 0.0200387 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0199268 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0198868 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0198117 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0197239 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0194355 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0194029 |
| RPS7 | ribosomal protein S7 | 0.0192352 |
| SOCS6 | suppressor of cytokine signaling 6 | 0.0191357 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0190373 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0188138 |
| YAP1 | Yes-associated protein 1 | 0.0187882 |
| RPL31 | ribosomal protein L31 | 0.0184894 |
| SP3 | Sp3 transcription factor | 0.0184088 |
| RPL11 | ribosomal protein L11 | 0.0183186 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0181865 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.180376 |
| TP63 | tumor protein p63 | -0.136884 |
| VIM | vimentin | -0.121192 |
| CD44 | CD44 molecule (Indian blood group) | -0.117336 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.103364 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0913223 |
| TMSB10 | thymosin beta 10 | -0.0866266 |
| HLA-B | major histocompatibility complex, class I, B | -0.0708706 |
| EHBP1 | EH domain binding protein 1 | -0.0672076 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0671553 |
| CADM2 | cell adhesion molecule 2 | -0.0604201 |
| SP100 | SP100 nuclear antigen | -0.0598555 |
| RPL35A | ribosomal protein L35a | -0.0598288 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0568105 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0555923 |
| TMSB4X | thymosin beta 4, X-linked | -0.0541591 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0533126 |
| RIGI | RNA sensor RIG-I | -0.0490757 |
| RNF213 | ring finger protein 213 | -0.0488173 |
| EPHA4 | EPH receptor A4 | -0.0483415 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0477329 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0466596 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0463995 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0442506 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0421595 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0419792 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0414948 |
| POTEF | POTE ankyrin domain family, member F | -0.039139 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0390811 |
| TMEM123 | transmembrane protein 123 | -0.0383782 |
| CANX | calnexin | -0.036652 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0365357 |
| TNS3 | tensin 3 | -0.0342072 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0339158 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0337189 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.033688 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0331045 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0329877 |
| CAVIN1 | caveolae associated protein 1 | -0.0324292 |
| GNAS | GNAS complex locus | -0.0321959 |
| LMAN1 | lectin, mannose-binding, 1 | -0.030937 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0307708 |
| GLG1 | golgi glycoprotein 1 | -0.030509 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0298021 |
| YBX1 | Y box binding protein 1 | -0.0297484 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0297144 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0296746 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0296569 |
| ENO1 | enolase 1, (alpha) | -0.02911 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0289896 |
| HMGB1 | high mobility group box 1 | -0.0289061 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.0287704 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0286617 |
| WDR45B | WD repeat domain 45B | -0.0284407 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0280815 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.027729 |
| CENPF | centromere protein F, 350/400kDa | -0.0276143 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0275404 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.027178 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0271227 |
| DEK | DEK proto-oncogene | -0.0268612 |
| CUX1 | cut-like homeobox 1 | -0.0267393 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0260495 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0258777 |
| RPS24 | ribosomal protein S24 | -0.0256702 |
| MAP4 | microtubule-associated protein 4 | -0.0253811 |
| SEPTIN7 | septin 7 | -0.0251019 |
| NDRG1 | N-myc downstream regulated 1 | -0.0249764 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0246774 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0245495 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0240613 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.023812 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0237204 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0236252 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0235429 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0233713 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0229273 |
| APP | amyloid beta (A4) precursor protein | -0.0227987 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0226932 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0225008 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0225001 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0222994 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0221259 |
| MYOF | myoferlin | -0.0220424 |
| MATR3 | matrin 3 | -0.021952 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0217552 |
| TUBB | tubulin, beta class I | -0.021681 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0215302 |
| XAF1 | XIAP associated factor 1 | -0.0213205 |
| COL5A2 | collagen, type V, alpha 2 | -0.0210216 |
| RTN3 | reticulon 3 | -0.0210081 |
| WASF2 | WAS protein family, member 2 | -0.0207458 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0207427 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0206675 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0206609 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0205869 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0203378 |
| MKI67 | marker of proliferation Ki-67 | -0.0202771 |
| AHNAK | AHNAK nucleoprotein | -0.0202555 |
| PLSCR1 | phospholipid scramblase 1 | -0.0202065 |
