Ciclopirox_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ciclopirox_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.148703
MCL1 myeloid cell leukemia 1 0.140358
SLTM SAFB-like, transcription modulator 0.131503
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.119064
NSUN6 NOP2/Sun domain family, member 6 0.0930494
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0835993
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0787199
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0746741
MT2A metallothionein 2A 0.0692773
AREG amphiregulin 0.0679129
ELL2 elongation factor, RNA polymerase II, 2 0.0667401
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0655273
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0648361
DOCK5 dedicator of cytokinesis 5 0.0542865
NAMPT nicotinamide phosphoribosyltransferase 0.0539259
BCAR3 breast cancer anti-estrogen resistance 3 0.0501283
LAMA4 laminin, alpha 4 0.0499486
CCNL1 cyclin L1 0.0496306
NABP1 nucleic acid binding protein 1 0.047582
JMJD1C jumonji domain containing 1C 0.046313
OSMR oncostatin M receptor 0.0458405
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0449059
UBC ubiquitin C 0.0441282
BLZF1 basic leucine zipper nuclear factor 1 0.0435128
DSCAM Down syndrome cell adhesion molecule 0.0424525
STC1 stanniocalcin 1 0.0405393
AGO2 argonaute RISC catalytic component 2 0.0373879
MYH9 myosin, heavy chain 9, non-muscle 0.0360374
CEMIP cell migration inducing protein, hyaluronan binding 0.0352013
LMO7 LIM domain 7 0.0347887
EXT1 exostosin glycosyltransferase 1 0.0337094
TSC22D2 TSC22 domain family, member 2 0.0336399
TOP1 topoisomerase (DNA) I 0.0335097
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0334247
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0333492
TJP1 tight junction protein 1 0.0326909
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0326024
SYAP1 synapse associated protein 1 0.0323308
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0318939
BMP6 bone morphogenetic protein 6 0.0309096
SAMD4A sterile alpha motif domain containing 4A 0.0307643
VMP1 vacuole membrane protein 1 0.030475
IGFBP3 insulin-like growth factor binding protein 3 0.0303953
PM20D1 peptidase M20 domain containing 1 0.0300831
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0299738
TRIP12 thyroid hormone receptor interactor 12 0.0294717
CTNND1 catenin (cadherin-associated protein), delta 1 0.0293797
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0289904
RTN4 reticulon 4 0.0289419
SIK3 SIK family kinase 3 0.0288586
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0282644
SFPQ splicing factor proline/glutamine-rich 0.0280339
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0273115
NPC1 Niemann-Pick disease, type C1 0.0271415
CSNK1E casein kinase 1, epsilon 0.0268587
MSN moesin 0.0268139
RNF149 ring finger protein 149 0.0267146
MED13L mediator complex subunit 13-like 0.0265579
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0264492
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0264041
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0262099
GRAMD1B GRAM domain containing 1B 0.0261831
RAB27B RAB27B, member RAS oncogene family 0.0259783
NDRG1 N-myc downstream regulated 1 0.0257705
EPAS1 endothelial PAS domain protein 1 0.025752
YBX3 Y box binding protein 3 0.025198
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0251371
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0250499
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0250233
RNF213 ring finger protein 213 0.024756
ZFAND6 zinc finger, AN1-type domain 6 0.0246372
ARGLU1 arginine and glutamate rich 1 0.024557
TIAM1 T-cell lymphoma invasion and metastasis 1 0.0244014
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0242913
SRSF5 serine/arginine-rich splicing factor 5 0.0242795
B2M beta-2-microglobulin 0.0241781
ATP13A3 ATPase type 13A3 0.0239059
RICTOR RPTOR independent companion of MTOR, complex 2 0.0235718
MT1X metallothionein 1X 0.0235027
NTN4 netrin 4 0.0233166
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0232848
EFNA5 ephrin-A5 0.0232838
SPRED2 sprouty-related, EVH1 domain containing 2 0.0232545
RAD51B RAD51 paralog B 0.0228481
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0228251
YAP1 Yes-associated protein 1 0.022583
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0224994
SPAG9 sperm associated antigen 9 0.0222746
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0220254
OXSR1 oxidative stress responsive 1 0.0218758
SRRM2 serine/arginine repetitive matrix 2 0.0218368
RCOR1 REST corepressor 1 0.0218127
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0216027
LRP1B low density lipoprotein receptor-related protein 1B 0.0210294
ATAD2B ATPase family, AAA domain containing 2B 0.0207802
DUSP5 dual specificity phosphatase 5 0.0205783
SPRED1 sprouty-related, EVH1 domain containing 1 0.0205359
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0205179
PLAUR plasminogen activator, urokinase receptor 0.020495
RUNX1 runt-related transcription factor 1 0.0203277

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.296939
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.191244
TMSB10 thymosin beta 10 -0.177936
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.166895
CAV1 caveolin 1, caveolae protein, 22kDa -0.118259
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.114957
PTMA prothymosin, alpha -0.10329
AHNAK AHNAK nucleoprotein -0.0758701
KRT18 keratin 18, type I -0.0743254
ANXA2 annexin A2 -0.0741014
ENO1 enolase 1, (alpha) -0.07066
TXNRD1 thioredoxin reductase 1 -0.0705352
HDLBP high density lipoprotein binding protein -0.070368
ACTG1 actin gamma 1 -0.066733
KRT7 keratin 7, type II -0.0664908
CANX calnexin -0.0653636
S100A10 S100 calcium binding protein A10 -0.0597661
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0591701
AKR1C1 aldo-keto reductase family 1, member C1 -0.0586582
ASPH aspartate beta-hydroxylase -0.0574359
PDIA3 protein disulfide isomerase family A, member 3 -0.0522684
IGFBP5 insulin-like growth factor binding protein 5 -0.0522482
PTPRM protein tyrosine phosphatase, receptor type, M -0.0507483
CCND1 cyclin D1 -0.0496437
LOC112694756 uncharaterized LOC112694756 -0.049592
LDHA lactate dehydrogenase A -0.0460718
AGR2 anterior gradient 2 -0.0460018
BIRC3 baculoviral IAP repeat containing 3 -0.0440749
PKM pyruvate kinase, muscle -0.043307
CST3 cystatin C -0.0429562
RPL35A ribosomal protein L35a -0.0427325
BZW1 basic leucine zipper and W2 domains 1 -0.0426922
GCLC glutamate-cysteine ligase, catalytic subunit -0.0404035
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0400705
FTH1 ferritin, heavy polypeptide 1 -0.0397409
RPL34 ribosomal protein L34 -0.0395786
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0395401
DSPP dentin sialophosphoprotein -0.0391219
TPM4 tropomyosin 4 -0.0361121
MYOF myoferlin -0.0358956
GOLGB1 golgin B1 -0.0358465
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0358381
AKAP12 A kinase (PRKA) anchor protein 12 -0.0357037
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0352915
SCEL sciellin -0.0345929
RPLP1 ribosomal protein, large, P1 -0.0345679
GNAS GNAS complex locus -0.0338681
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0329514
RPS6 ribosomal protein S6 -0.0319462
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0315725
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0309821
RAB1A RAB1A, member RAS oncogene family -0.0300199
TAS2R14 taste receptor, type 2, member 14 -0.0296501
RPS24 ribosomal protein S24 -0.029314
PDIA6 protein disulfide isomerase family A, member 6 -0.0285948
PATJ PATJ crumbs cell polarity complex component -0.0285262
KRT8 keratin 8, type II -0.0284598
CAV2 caveolin 2 -0.0282083
RPL4 ribosomal protein L4 -0.0281688
ARF1 ADP-ribosylation factor 1 -0.0274246
KRT19 keratin 19, type I -0.0270651
SEC61G Sec61 gamma subunit -0.026961
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0262834
DSG2 desmoglein 2 -0.0256239
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0253973
SEC31A SEC31 homolog A (S. cerevisiae) -0.0251652
HM13 histocompatibility (minor) 13 -0.0250905
AHNAK2 AHNAK nucleoprotein 2 -0.0245983
SPIRE1 spire-type actin nucleation factor 1 -0.0244355
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0238347
FLNB filamin B, beta -0.0237968
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0237413
UGDH UDP-glucose 6-dehydrogenase -0.0236042
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0235715
HMGA1 high mobility group AT-hook 1 -0.023566
ZMYND8 zinc finger, MYND-type containing 8 -0.0232263
RPL19 ribosomal protein L19 -0.0231586
IER3 immediate early response 3 -0.0230835
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0229168
TKT transketolase -0.0226804
ARCN1 archain 1 -0.0225585
KDM3A lysine (K)-specific demethylase 3A -0.0225496
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0223386
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0220146
S100A11 S100 calcium binding protein A11 -0.0219476
RPS8 ribosomal protein S8 -0.0217175
POTEF POTE ankyrin domain family, member F -0.0215994
BMP7 bone morphogenetic protein 7 -0.0213773
KPNB1 karyopherin (importin) beta 1 -0.02111
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0210855
SRP72 signal recognition particle 72kDa -0.0207431
LMAN1 lectin, mannose-binding, 1 -0.0206851
PRKCA protein kinase C, alpha -0.0201192
SEC24D SEC24 family member D -0.0200389
RPL12 ribosomal protein L12 -0.0199119
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0197816
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.019098
SQSTM1 sequestosome 1 -0.0190946
GOLGA4 golgin A4 -0.0189535
CAPN2 calpain 2, (m/II) large subunit -0.0188359