| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ciclopirox perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ciclopirox_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0984005 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0938952 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0909084 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0869967 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0802271 |
| CD44 | CD44 molecule (Indian blood group) | 0.0790458 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0748507 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0722753 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0720759 |
| SIK3 | SIK family kinase 3 | 0.0707816 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0682774 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0666473 |
| NRP1 | neuropilin 1 | 0.0649467 |
| MT2A | metallothionein 2A | 0.0631212 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0626839 |
| PCBP2 | poly(rC) binding protein 2 | 0.0615032 |
| FTL | ferritin, light polypeptide | 0.0574924 |
| B2M | beta-2-microglobulin | 0.0539671 |
| MCL1 | myeloid cell leukemia 1 | 0.0533321 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0505215 |
| GLCCI1 | glucocorticoid induced 1 | 0.0503181 |
| SMAD3 | SMAD family member 3 | 0.0493771 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0492509 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0482909 |
| HAS2 | hyaluronan synthase 2 | 0.0482568 |
| HMGA1 | high mobility group AT-hook 1 | 0.0473168 |
| NDRG1 | N-myc downstream regulated 1 | 0.0473047 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0412841 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0412346 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0408882 |
| IFI44L | interferon-induced protein 44-like | 0.0402145 |
| STK38L | serine/threonine kinase 38 like | 0.0394103 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0386823 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0373419 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0370936 |
| ECE1 | endothelin converting enzyme 1 | 0.0370595 |
| ANGPTL4 | angiopoietin-like 4 | 0.0362451 |
| ITGAV | integrin, alpha V | 0.0360459 |
| RAD51B | RAD51 paralog B | 0.0360178 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0354592 |
| VIM | vimentin | 0.0351185 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0345729 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0343609 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0333442 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0323587 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0322121 |
| TGM2 | transglutaminase 2 | 0.0321544 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0320132 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0317129 |
| MSN | moesin | 0.0316052 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0315296 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0313079 |
| RASAL2 | RAS protein activator like 2 | 0.0308372 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0306062 |
| ACTN4 | actinin, alpha 4 | 0.030477 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0303318 |
| FHL2 | four and a half LIM domains 2 | 0.0302785 |
| NTN4 | netrin 4 | 0.0299636 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0296958 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0290913 |
| PRSS23 | protease, serine, 23 | 0.0286901 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.028619 |
| VMP1 | vacuole membrane protein 1 | 0.0281425 |
| ADD3 | adducin 3 (gamma) | 0.0277293 |
| S100A6 | S100 calcium binding protein A6 | 0.0276322 |
| RPS12 | ribosomal protein S12 | 0.0274809 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0268792 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0268299 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0266032 |
| SYNJ2 | synaptojanin 2 | 0.026523 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0254711 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0254407 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0253154 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0252122 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0251965 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0250666 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0248913 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0248888 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0245027 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0243949 |
| CDCP1 | CUB domain containing protein 1 | 0.0242452 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.024221 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0241167 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0240226 |
| MYADM | myeloid-associated differentiation marker | 0.0239469 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0239207 |
| HMGA2 | high mobility group AT-hook 2 | 0.023916 |
| EZR | ezrin | 0.0239052 |
| RNF144A | ring finger protein 144A | 0.0238699 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.023637 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.02363 |
| VEGFA | vascular endothelial growth factor A | 0.0235659 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0232292 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0231448 |
| ADM | adrenomedullin | 0.0229739 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0227402 |
| DOCK5 | dedicator of cytokinesis 5 | 0.022602 |
| PTK2 | protein tyrosine kinase 2 | 0.0225772 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0225623 |
| JMJD1C | jumonji domain containing 1C | 0.0225197 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.271525 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.139271 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.133649 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.120714 |
| NRG1 | neuregulin 1 | -0.108469 |
| CANX | calnexin | -0.0780179 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0776864 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0776213 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0718239 |
| GOLGA4 | golgin A4 | -0.0635413 |
| LOX | lysyl oxidase | -0.0632321 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0607949 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0585218 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0576802 |
| CDH13 | cadherin 13 | -0.0559775 |
| STC1 | stanniocalcin 1 | -0.0548815 |
| HDLBP | high density lipoprotein binding protein | -0.0534796 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0520284 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0517713 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.051203 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0511573 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0503389 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0495436 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0495287 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0486327 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0481356 |
| USP34 | ubiquitin specific peptidase 34 | -0.0454773 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0453491 |
| FAM20C | family with sequence similarity 20, member C | -0.043848 |
| MTSS1 | metastasis suppressor 1 | -0.0427469 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0408323 |
| ATG7 | autophagy related 7 | -0.0406376 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0406054 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0400384 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0400078 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0394219 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0389765 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.038404 |
| AHNAK | AHNAK nucleoprotein | -0.0383064 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0377197 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0374971 |
| FBN1 | fibrillin 1 | -0.035903 |
| TMEM263 | transmembrane protein 263 | -0.035441 |
| VRK2 | vaccinia related kinase 2 | -0.034815 |
| DNER | delta/notch-like EGF repeat containing | -0.0348012 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0346433 |
| FRMD4A | FERM domain containing 4A | -0.0343627 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0341153 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0334174 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0328595 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0324901 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0322529 |
| DENND4A | DENN/MADD domain containing 4A | -0.032077 |
| RBM39 | RNA binding motif protein 39 | -0.0318023 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0311598 |
| TMSB10 | thymosin beta 10 | -0.0311421 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0305572 |
| HM13 | histocompatibility (minor) 13 | -0.0302578 |
| INSIG1 | insulin induced gene 1 | -0.0302035 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.0297557 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0295013 |
| ANKRD17 | ankyrin repeat domain 17 | -0.029133 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0286549 |
| MEF2A | myocyte enhancer factor 2A | -0.0285977 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0285273 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0284835 |
| WDR45B | WD repeat domain 45B | -0.0284061 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0282325 |
| COL12A1 | collagen, type XII, alpha 1 | -0.0282084 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0278519 |
| IER3 | immediate early response 3 | -0.02784 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.027824 |
| USP15 | ubiquitin specific peptidase 15 | -0.0269974 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0267676 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0265398 |
| DENND1A | DENN/MADD domain containing 1A | -0.0265221 |
| LRRC49 | leucine rich repeat containing 49 | -0.0264621 |
| THBS1 | thrombospondin 1 | -0.0262143 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.025431 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0252106 |
| CP | ceruloplasmin (ferroxidase) | -0.0247716 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0247006 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0245031 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0243354 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0243353 |
| SEC24D | SEC24 family member D | -0.0242666 |
| FANK1 | fibronectin type III and ankyrin repeat domains 1 | -0.0240651 |
| FDPS | farnesyl diphosphate synthase | -0.0237453 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0236336 |
| CDK14 | cyclin-dependent kinase 14 | -0.0235684 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0233838 |
| NUMB | numb homolog (Drosophila) | -0.0233132 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0232571 |
| AAK1 | AP2 associated kinase 1 | -0.0230264 |
| SNX14 | sorting nexin 14 | -0.0229275 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.0228709 |
| NAV3 | neuron navigator 3 | -0.0226845 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0226642 |
| OSMR | oncostatin M receptor | -0.0226495 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.022486 |
