Ciclopirox_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ciclopirox_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.225879
MT2A metallothionein 2A 0.202798
PM20D1 peptidase M20 domain containing 1 0.197496
MCL1 myeloid cell leukemia 1 0.0887369
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0708965
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0614864
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0532617
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0445726
RICTOR RPTOR independent companion of MTOR, complex 2 0.0441434
MSN moesin 0.0432038
KYNU kynureninase 0.0422895
SFPQ splicing factor proline/glutamine-rich 0.0421432
DOCK5 dedicator of cytokinesis 5 0.0413832
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0406294
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0403854
BMP6 bone morphogenetic protein 6 0.040139
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0394929
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0389488
NTN4 netrin 4 0.0375159
VMP1 vacuole membrane protein 1 0.0360898
IGFBP3 insulin-like growth factor binding protein 3 0.0356506
MYH9 myosin, heavy chain 9, non-muscle 0.0351426
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0351331
BCAR3 breast cancer anti-estrogen resistance 3 0.0351307
AKAP12 A kinase (PRKA) anchor protein 12 0.033685
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0324113
CFLAR CASP8 and FADD-like apoptosis regulator 0.0318709
ERRFI1 ERBB receptor feedback inhibitor 1 0.0313797
NCEH1 neutral cholesterol ester hydrolase 1 0.0305251
BRD2 bromodomain containing 2 0.0301175
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0300743
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0293557
ERBIN erbb2 interacting protein 0.0289528
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.028795
FAM107B family with sequence similarity 107, member B 0.0285887
JMJD1C jumonji domain containing 1C 0.0283884
DSCAM Down syndrome cell adhesion molecule 0.0280059
RPS12 ribosomal protein S12 0.0278943
RPL3 ribosomal protein L3 0.0272461
UBC ubiquitin C 0.0257828
UBASH3B ubiquitin associated and SH3 domain containing B 0.0252067
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0250516
CHD1 chromodomain helicase DNA binding protein 1 0.02474
B2M beta-2-microglobulin 0.0245309
KTN1 kinectin 1 (kinesin receptor) 0.0240895
USP36 ubiquitin specific peptidase 36 0.0238346
RCOR1 REST corepressor 1 0.0237882
TIMP1 TIMP metallopeptidase inhibitor 1 0.0236339
ELL2 elongation factor, RNA polymerase II, 2 0.023461
YLPM1 YLP motif containing 1 0.0233194
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0225631
EEF2 eukaryotic translation elongation factor 2 0.0224219
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0223442
NPC1 Niemann-Pick disease, type C1 0.0223105
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0222177
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0220029
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.02173
DOCK4 dedicator of cytokinesis 4 0.021715
SMOC1 SPARC related modular calcium binding 1 0.0214476
ACTN1 actinin, alpha 1 0.0214195
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0211878
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0207582
AGO2 argonaute RISC catalytic component 2 0.0204335
VEZT vezatin, adherens junctions transmembrane protein 0.0204077
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0203621
SCAF8 SR-related CTD-associated factor 8 0.0203177
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.020293
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0202556
WAC WW domain containing adaptor with coiled-coil 0.0201028
PTBP2 polypyrimidine tract binding protein 2 0.020005
SRSF4 serine/arginine-rich splicing factor 4 0.0199158
SAMD4A sterile alpha motif domain containing 4A 0.0197231
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0196079
SLC38A2 solute carrier family 38, member 2 0.0196021
SETD5 SET domain containing 5 0.0195178
SRSF11 serine/arginine-rich splicing factor 11 0.0191974
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0191068
RPS13 ribosomal protein S13 0.0189931
AKAP13 A kinase (PRKA) anchor protein 13 0.0185597
TERF2IP telomeric repeat binding factor 2, interacting protein 0.0185514
AXL AXL receptor tyrosine kinase 0.0184137
APLP2 amyloid beta (A4) precursor-like protein 2 0.0183444
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0183194
PDLIM5 PDZ and LIM domain 5 0.0183087
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0182903
DSE dermatan sulfate epimerase 0.0182494
DCAF8 DDB1 and CUL4 associated factor 8 0.0181623
KIF1B kinesin family member 1B 0.0179947
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.01798
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0178507
LAMC2 laminin, gamma 2 0.0177604
ITGAV integrin, alpha V 0.0177405
SRRM2 serine/arginine repetitive matrix 2 0.017531
AMOTL1 angiomotin like 1 0.0174578
SP3 Sp3 transcription factor 0.0173858
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0171238
PLS3 plastin 3 0.0170163
EIF5 eukaryotic translation initiation factor 5 0.0169432
HDAC9 histone deacetylase 9 0.0168602
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0168149

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.168507
VIM vimentin -0.163977
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.140674
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127033
TMSB10 thymosin beta 10 -0.123561
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.104907
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0855748
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0822166
IER3 immediate early response 3 -0.07943
BASP1 brain abundant, membrane attached signal protein 1 -0.0787206
FTH1 ferritin, heavy polypeptide 1 -0.0749403
PTMA prothymosin, alpha -0.0747205
TFPI2 tissue factor pathway inhibitor 2 -0.0678933
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0633914
RPL35A ribosomal protein L35a -0.0625114
CAVIN1 caveolae associated protein 1 -0.0584604
ACTG1 actin gamma 1 -0.056888
TPM4 tropomyosin 4 -0.0563557
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0560371
AHNAK AHNAK nucleoprotein -0.0558826
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0554129
IGF2 insulin-like growth factor 2 -0.0525499
GNAS GNAS complex locus -0.0496172
ANXA2 annexin A2 -0.0485018
C15ORF48 chromosome 15 open reading frame 48 -0.0477056
ENO1 enolase 1, (alpha) -0.0475848
S100A6 S100 calcium binding protein A6 -0.0467548
NEGR1 neuronal growth regulator 1 -0.0465056
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0448257
HMGB1 high mobility group box 1 -0.040898
THSD4 thrombospondin, type I, domain containing 4 -0.0394066
RPL4 ribosomal protein L4 -0.0387358
SRGN serglycin -0.0386171
PDIA3 protein disulfide isomerase family A, member 3 -0.0381045
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0380813
RAB1A RAB1A, member RAS oncogene family -0.0379696
STC1 stanniocalcin 1 -0.0373327
SLC38A1 solute carrier family 38, member 1 -0.0372782
KDM3A lysine (K)-specific demethylase 3A -0.0370144
RAD21 RAD21 homolog (S. pombe) -0.0368419
THBS1 thrombospondin 1 -0.0365901
COTL1 coactosin-like F-actin binding protein 1 -0.0365043
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0363043
SQSTM1 sequestosome 1 -0.0362581
PDE4D phosphodiesterase 4D, cAMP-specific -0.0358771
RAB7A RAB7A, member RAS oncogene family -0.0357215
BICC1 BicC family RNA binding protein 1 -0.0353026
TPT1 tumor protein, translationally-controlled 1 -0.0350748
RPL34 ribosomal protein L34 -0.0347644
CANX calnexin -0.0347511
DST dystonin -0.0344823
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0340507
PKM pyruvate kinase, muscle -0.0336432
RPLP1 ribosomal protein, large, P1 -0.0335883
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0335077
IGFBP4 insulin-like growth factor binding protein 4 -0.0331956
ZMYND8 zinc finger, MYND-type containing 8 -0.0329944
MYL12B myosin, light chain 12B, regulatory -0.0327619
POTEF POTE ankyrin domain family, member F -0.0324218
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0313453
TUBB tubulin, beta class I -0.0310418
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0305768
CLDN1 claudin 1 -0.0302162
BIRC3 baculoviral IAP repeat containing 3 -0.0301029
MORF4L2 mortality factor 4 like 2 -0.0297802
FTL ferritin, light polypeptide -0.0296072
SLC35F3 solute carrier family 35, member F3 -0.0289392
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0283715
UTRN utrophin -0.0281739
NAMPT nicotinamide phosphoribosyltransferase -0.0280423
SDC4 syndecan 4 -0.0279966
YBX1 Y box binding protein 1 -0.0278952
LDHA lactate dehydrogenase A -0.027559
KPNB1 karyopherin (importin) beta 1 -0.0274913
EHBP1 EH domain binding protein 1 -0.0273252
DEK DEK proto-oncogene -0.0272612
BLTP2 bridge-like lipid transfer protein family member 2 -0.0271938
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0269777
SEPTIN7 septin 7 -0.0268643
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0268248
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.026532
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0264791
BABAM2 BRISC and BRCA1 A complex member 2 -0.0264247
S100A10 S100 calcium binding protein A10 -0.0260408
ARHGAP26 Rho GTPase activating protein 26 -0.0254342
VDAC1 voltage-dependent anion channel 1 -0.0251267
LMAN1 lectin, mannose-binding, 1 -0.0250333
RSL1D1 ribosomal L1 domain containing 1 -0.0248204
RPS24 ribosomal protein S24 -0.0247859
EFNA5 ephrin-A5 -0.0247254
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0246659
JUN jun proto-oncogene -0.024638
VCL vinculin -0.0243151
TMEM123 transmembrane protein 123 -0.0239649
TMEM263 transmembrane protein 263 -0.0238037
LOC102724023 ES1 protein homolog, mitochondrial -0.0236574
ALCAM activated leukocyte cell adhesion molecule -0.0231921
IFRD1 interferon-related developmental regulator 1 -0.0226783
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0226362
CALU calumenin -0.0224228