Ciclopirox_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ciclopirox_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.217981
RIGI RNA sensor RIG-I 0.0828109
B2M beta-2-microglobulin 0.0793578
VIM vimentin 0.0776556
RPS6 ribosomal protein S6 0.0766082
DSCAM Down syndrome cell adhesion molecule 0.0753758
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0727603
ENO1 enolase 1, (alpha) 0.0721796
FNDC3B fibronectin type III domain containing 3B 0.0706339
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0697412
AKAP13 A kinase (PRKA) anchor protein 13 0.0670759
PGK1 phosphoglycerate kinase 1 0.0655926
RAD51B RAD51 paralog B 0.0643227
UBC ubiquitin C 0.0595245
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0584079
SOS1 son of sevenless homolog 1 (Drosophila) 0.0559097
NDRG1 N-myc downstream regulated 1 0.055713
PTK2 protein tyrosine kinase 2 0.0537455
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0537079
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0529103
HLA-B major histocompatibility complex, class I, B 0.0515534
FAT1 FAT atypical cadherin 1 0.0513537
RPLP0 ribosomal protein, large, P0 0.0499826
MT2A metallothionein 2A 0.0497902
RNF213 ring finger protein 213 0.0493977
TMSB10 thymosin beta 10 0.0491305
RSAD2 radical S-adenosyl methionine domain containing 2 0.0481101
KMT2E lysine (K)-specific methyltransferase 2E 0.047162
NCOA3 nuclear receptor coactivator 3 0.047067
GOLGA4 golgin A4 0.0454383
TM4SF1 transmembrane 4 L six family member 1 0.0452919
RBM25 RNA binding motif protein 25 0.0451506
CSNK1A1 casein kinase 1, alpha 1 0.0451155
MYH9 myosin, heavy chain 9, non-muscle 0.0447874
EIF1 eukaryotic translation initiation factor 1 0.0446297
H3-3B H3.3 histone B 0.0444663
RPS3 ribosomal protein S3 0.0444437
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.04334
FNDC3A fibronectin type III domain containing 3A 0.0430064
AKAP12 A kinase (PRKA) anchor protein 12 0.0428151
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0423314
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0416678
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0415037
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0406192
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0404747
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0401323
KYNU kynureninase 0.039754
IGFBP3 insulin-like growth factor binding protein 3 0.0396775
THSD4 thrombospondin, type I, domain containing 4 0.038716
TPT1 tumor protein, translationally-controlled 1 0.038329
KMT2C lysine (K)-specific methyltransferase 2C 0.0380108
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0378935
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0378268
NPAS2 neuronal PAS domain protein 2 0.0376651
NAP1L1 nucleosome assembly protein 1-like 1 0.0373124
FTL ferritin, light polypeptide 0.0368914
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0367821
IFIH1 interferon induced with helicase C domain 1 0.0367691
TXNRD1 thioredoxin reductase 1 0.03667
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0365448
NCOR1 nuclear receptor corepressor 1 0.0365227
SRRM2 serine/arginine repetitive matrix 2 0.0363398
VCL vinculin 0.036226
RPS24 ribosomal protein S24 0.0361574
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0360469
CANX calnexin 0.0357548
RPS16 ribosomal protein S16 0.0355556
IRS2 insulin receptor substrate 2 0.0355439
MACF1 microtubule-actin crosslinking factor 1 0.0354321
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0350785
FLNB filamin B, beta 0.0348001
LPP LIM domain containing preferred translocation partner in lipoma 0.034767
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0346637
CCL5 chemokine (C-C motif) ligand 5 0.034439
CDK6 cyclin-dependent kinase 6 0.0339586
BTBD9 BTB (POZ) domain containing 9 0.0338893
DSPP dentin sialophosphoprotein 0.0335902
RPL30 ribosomal protein L30 0.0333294
S100A6 S100 calcium binding protein A6 0.0332742
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0329875
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0328513
SLTM SAFB-like, transcription modulator 0.0328238
PTMA prothymosin, alpha 0.0324015
RPL23 ribosomal protein L23 0.0322376
SLC38A1 solute carrier family 38, member 1 0.0317746
PHF3 PHD finger protein 3 0.0317009
ABHD2 abhydrolase domain containing 2 0.0316031
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0314672
RPL26 ribosomal protein L26 0.0311249
OASL 2'-5'-oligoadenylate synthetase-like 0.0309681
SLK STE20-like kinase 0.0307524
NF1 neurofibromin 1 0.0307359
RPLP2 ribosomal protein, large, P2 0.0303896
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0301686
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0300107
AFF1 AF4/FMR2 family, member 1 0.0298333
ASPH aspartate beta-hydroxylase 0.0296307
RPL28 ribosomal protein L28 0.0296117
TTC3 tetratricopeptide repeat domain 3 0.0294858
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0294001

decreased expression

Symbol Name Standardized Value
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.14447
CEMIP cell migration inducing protein, hyaluronan binding -0.127335
SAMD4A sterile alpha motif domain containing 4A -0.117239
GRB10 growth factor receptor-bound protein 10 -0.0904561
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0855754
ATOSA atos homolog A -0.0846218
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0727185
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0718986
MUC16 mucin 16, cell surface associated -0.0645351
MMP1 matrix metallopeptidase 1 -0.0622114
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0620294
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0598631
FTH1 ferritin, heavy polypeptide 1 -0.0551904
SHB Src homology 2 domain containing adaptor protein B -0.0540591
RBM47 RNA binding motif protein 47 -0.0511094
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.049917
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0479547
STEAP4 STEAP family member 4 -0.045835
FAM13A family with sequence similarity 13, member A -0.0452568
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0451172
ADGRB3 adhesion G protein-coupled receptor B3 -0.044556
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0430602
KRT17 keratin 17, type I -0.042933
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0425671
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0423755
MAML2 mastermind-like 2 (Drosophila) -0.0422853
TMPRSS4 transmembrane protease, serine 4 -0.0418453
NALF1 NALCN channel auxiliary factor 1 -0.0416908
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0416819
ABI3BP ABI family, member 3 (NESH) binding protein -0.0415755
CATSPERB catsper channel auxiliary subunit beta -0.0415559
ZNF217 zinc finger protein 217 -0.0402192
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0400817
COL6A3 collagen, type VI, alpha 3 -0.0394876
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0391893
ANXA1 annexin A1 -0.0387844
ABHD17C abhydrolase domain containing 17C -0.0382039
TC2N tandem C2 domains, nuclear -0.0380211
SH3PXD2A SH3 and PX domains 2A -0.0378949
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0373871
LAMB3 laminin, beta 3 -0.0372015
THRB thyroid hormone receptor, beta -0.0369338
SOX4 SRY (sex determining region Y)-box 4 -0.0365992
SDCBP2 syndecan binding protein (syntenin) 2 -0.036031
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0359677
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0359641
BACE2 beta-site APP-cleaving enzyme 2 -0.0359278
SEPTIN10 septin 10 -0.0356698
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -0.0349377
LIMCH1 LIM and calponin homology domains 1 -0.0346457
CLMP CXADR-like membrane protein -0.0345763
HOMER1 homer scaffolding protein 1 -0.0345367
USP3 ubiquitin specific peptidase 3 -0.0343416
ARHGAP27 Rho GTPase activating protein 27 -0.0341754
CMIP c-Maf inducing protein -0.0341241
RESF1 retroelement silencing factor 1 -0.0340044
TAOK3 TAO kinase 3 -0.0339524
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0335965
TRIP11 thyroid hormone receptor interactor 11 -0.0332448
KLF3 Kruppel-like factor 3 (basic) -0.0332426
ZNF185 zinc finger protein 185 (LIM domain) -0.033109
KLF5 Kruppel-like factor 5 (intestinal) -0.033044
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0326828
CD59 CD59 molecule, complement regulatory protein -0.0325499
PRKG1 protein kinase, cGMP-dependent, type I -0.0320612
COL5A1 collagen, type V, alpha 1 -0.0320432
TJP2 tight junction protein 2 -0.0319683
SACK1A scaffolding CK1 anchoring protein A -0.0319586
CDYL chromodomain protein, Y-like -0.0318756
HPCAL1 hippocalcin-like 1 -0.0317299
GDNF glial cell derived neurotrophic factor -0.0317107
TBL1X transducin (beta)-like 1X-linked -0.0316203
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0315402
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0314583
PLEC plectin -0.0310481
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0310035
IRF6 interferon regulatory factor 6 -0.0309045
IL4R interleukin 4 receptor -0.0307741
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0306837
ARHGAP12 Rho GTPase activating protein 12 -0.0305972
ERBIN erbb2 interacting protein -0.0305712
LAMC2 laminin, gamma 2 -0.0305369
KDM3B lysine (K)-specific demethylase 3B -0.0305367
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0302201
USP15 ubiquitin specific peptidase 15 -0.0300038
SAMD5 sterile alpha motif domain containing 5 -0.0299762
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0298306
TMCC3 transmembrane and coiled-coil domain family 3 -0.0297708
GLUL glutamate-ammonia ligase -0.0293752
KDM3A lysine (K)-specific demethylase 3A -0.029322
EXOC6B exocyst complex component 6B -0.0292139
FDPS farnesyl diphosphate synthase -0.0289447
ITGB4 integrin, beta 4 -0.0289137
ADAM28 ADAM metallopeptidase domain 28 -0.0289064
SREK1IP1 SREK1-interacting protein 1 -0.0289042
BTG1 B-cell translocation gene 1, anti-proliferative -0.0286138
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0285769
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0285592
GRB7 growth factor receptor-bound protein 7 -0.028533
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0281877