| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ciclopirox perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ciclopirox_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.191025 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.184639 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.161923 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.105601 |
| YBX3 | Y box binding protein 3 | 0.101045 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.100382 |
| MCL1 | myeloid cell leukemia 1 | 0.0992028 |
| ACTG1 | actin gamma 1 | 0.0968233 |
| VCL | vinculin | 0.075646 |
| NF1 | neurofibromin 1 | 0.0754709 |
| PDE10A | phosphodiesterase 10A | 0.07371 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0686993 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0679203 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0638891 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0628245 |
| ATXN1 | ataxin 1 | 0.0626555 |
| HLA-B | major histocompatibility complex, class I, B | 0.0625543 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0616141 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0607581 |
| INTS6 | integrator complex subunit 6 | 0.0603781 |
| MT2A | metallothionein 2A | 0.0533065 |
| AEBP2 | AE binding protein 2 | 0.0532713 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0530367 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.052483 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0520321 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0517181 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0516543 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0503051 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.049875 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0492219 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0489849 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0485489 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0484451 |
| CDK17 | cyclin-dependent kinase 17 | 0.0480391 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0480382 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0474434 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.046556 |
| WWOX | WW domain containing oxidoreductase | 0.0454201 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0451272 |
| RYR3 | ryanodine receptor 3 | 0.0449854 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0448182 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0429586 |
| TMSB10 | thymosin beta 10 | 0.042831 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0424564 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0423697 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0420534 |
| RAD51B | RAD51 paralog B | 0.0417027 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0414977 |
| PRELID2 | PRELI domain containing 2 | 0.0407619 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0403234 |
| UBC | ubiquitin C | 0.0403195 |
| IGF2 | insulin-like growth factor 2 | 0.0401874 |
| EXOC4 | exocyst complex component 4 | 0.0398559 |
| PYGL | phosphorylase, glycogen, liver | 0.0388997 |
| USP34 | ubiquitin specific peptidase 34 | 0.0386568 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0385251 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0375409 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0373155 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.036981 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0369723 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0367263 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0360665 |
| SSH2 | slingshot protein phosphatase 2 | 0.035959 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0358937 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0358538 |
| RPS21 | ribosomal protein S21 | 0.0358278 |
| DST | dystonin | 0.0356309 |
| CAPRIN2 | caprin family member 2 | 0.0356163 |
| RPL37 | ribosomal protein L37 | 0.0354684 |
| HOMER1 | homer scaffolding protein 1 | 0.0353596 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0350011 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0347516 |
| TPM2 | tropomyosin 2 (beta) | 0.0346185 |
| NCOA7 | nuclear receptor coactivator 7 | 0.033785 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0334394 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0329505 |
| PTK2 | protein tyrosine kinase 2 | 0.0322885 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0320828 |
| SVIL | supervillin | 0.0319329 |
| MYL12B | myosin, light chain 12B, regulatory | 0.031902 |
| TPI1 | triosephosphate isomerase 1 | 0.031605 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0314247 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0310469 |
| GNAS | GNAS complex locus | 0.0310314 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0307158 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0306674 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.0305385 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0303185 |
| RRM2 | ribonucleotide reductase M2 | 0.0288146 |
| CUX1 | cut-like homeobox 1 | 0.0286074 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0285136 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0284817 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0283184 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0281518 |
| H3-3B | H3.3 histone B | 0.0278682 |
| TUBA1B | tubulin, alpha 1b | 0.0278578 |
| CLTA | clathrin, light chain A | 0.0277553 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0276999 |
| MIDN | midnolin | 0.0276312 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0275314 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.101977 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0879124 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0771106 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0742562 |
| RTN4 | reticulon 4 | -0.0640477 |
| TFRC | transferrin receptor | -0.0572578 |
| RPS6 | ribosomal protein S6 | -0.0471523 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0465977 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0462527 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0461422 |
| RPS27 | ribosomal protein S27 | -0.0457525 |
| RPLP1 | ribosomal protein, large, P1 | -0.0456689 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0431904 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0421182 |
| GPHN | gephyrin | -0.0418678 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0407993 |
| MATR3 | matrin 3 | -0.0369528 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0366884 |
| TPM3 | tropomyosin 3 | -0.0365596 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0357763 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.035016 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0341504 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0339355 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0336576 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0336223 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0325074 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0313435 |
| EIF4B | eukaryotic translation initiation factor 4B | -0.031102 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0308051 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0305758 |
| OGA | O-GlcNAcase | -0.0303825 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0301295 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0300201 |
| MKI67 | marker of proliferation Ki-67 | -0.0297037 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | -0.0295964 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0293839 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0293692 |
| VIM | vimentin | -0.0287395 |
| RPS8 | ribosomal protein S8 | -0.0285863 |
| BBX | bobby sox homolog (Drosophila) | -0.0284135 |
| ERBIN | erbb2 interacting protein | -0.0278867 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.027324 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.027261 |
| CEP95 | centrosomal protein 95kDa | -0.02716 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0269003 |
| XPO1 | exportin 1 | -0.0262297 |
| PCBP2 | poly(rC) binding protein 2 | -0.0256339 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.025589 |
| PLSCR1 | phospholipid scramblase 1 | -0.0253652 |
| PHIP | pleckstrin homology domain interacting protein | -0.0252528 |
| YBX1 | Y box binding protein 1 | -0.024954 |
| EGR1 | early growth response 1 | -0.0249029 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0248276 |
| RPL4 | ribosomal protein L4 | -0.0247465 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.024689 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0238093 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.023639 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0234729 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0234443 |
| CCND2 | cyclin D2 | -0.0234391 |
| IMMT | inner membrane protein, mitochondrial | -0.0232522 |
| TUT4 | terminal uridylyl transferase 4 | -0.0231343 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0231135 |
| KLF10 | Kruppel-like factor 10 | -0.0229918 |
| NEK7 | NIMA-related kinase 7 | -0.0229723 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0229082 |
| XPO7 | exportin 7 | -0.0225863 |
| IKBIP | IKBKB interacting protein | -0.0225074 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.022217 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0217864 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0217844 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.0215716 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0215668 |
| ANO6 | anoctamin 6 | -0.0214082 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0212037 |
| RNF38 | ring finger protein 38 | -0.0208757 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0208489 |
| FHL2 | four and a half LIM domains 2 | -0.0208144 |
| TP53BP2 | tumor protein p53 binding protein 2 | -0.0207457 |
| ARF4 | ADP-ribosylation factor 4 | -0.020697 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0205656 |
| RPL35 | ribosomal protein L35 | -0.0204679 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0204296 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0203785 |
| ANXA5 | annexin A5 | -0.020235 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0202146 |
| CMAS | cytidine monophosphate N-acetylneuraminic acid synthetase | -0.0202098 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0201982 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0201263 |
| TWF1 | twinfilin actin binding protein 1 | -0.0201102 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0200121 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0199166 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0199056 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.019853 |
| LIMA1 | LIM domain and actin binding 1 | -0.0198477 |
| AHNAK | AHNAK nucleoprotein | -0.0198477 |
| WDR45B | WD repeat domain 45B | -0.0198468 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0197166 |
| SNU13 | small nuclear ribonucleoprotein 13 | -0.0197066 |
| RPIA | ribose 5-phosphate isomerase A | -0.0196998 |
