| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ciclopirox perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ciclopirox_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.180009 |
| COL5A2 | collagen, type V, alpha 2 | 0.121543 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.106407 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.106146 |
| FTL | ferritin, light polypeptide | 0.0909892 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0859641 |
| MT2A | metallothionein 2A | 0.0842398 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0822721 |
| PYGL | phosphorylase, glycogen, liver | 0.0796604 |
| GDA | guanine deaminase | 0.0785418 |
| CD109 | CD109 molecule | 0.0705562 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0659096 |
| RPS6 | ribosomal protein S6 | 0.0657653 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0649252 |
| RPLP0 | ribosomal protein, large, P0 | 0.0643529 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0627761 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0611812 |
| MSN | moesin | 0.0545038 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0539422 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0531581 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0496059 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0493715 |
| KYNU | kynureninase | 0.0487071 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0474202 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0440765 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0416713 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0415691 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.040587 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0398782 |
| DUSP4 | dual specificity phosphatase 4 | 0.0381727 |
| RPL7A | ribosomal protein L7a | 0.0379688 |
| ASTN2 | astrotactin 2 | 0.0378427 |
| PDE10A | phosphodiesterase 10A | 0.03742 |
| EGR1 | early growth response 1 | 0.0372609 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0368575 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0365783 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0365177 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0364548 |
| RPL7 | ribosomal protein L7 | 0.0360285 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.035411 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0347879 |
| KRT19 | keratin 19, type I | 0.0343132 |
| YBX3 | Y box binding protein 3 | 0.0335422 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0332032 |
| DOCK5 | dedicator of cytokinesis 5 | 0.03286 |
| GRAMD1B | GRAM domain containing 1B | 0.0328007 |
| MFF | mitochondrial fission factor | 0.0306179 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.030354 |
| SCARA5 | scavenger receptor class A, member 5 | 0.0303094 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0301296 |
| TXNIP | thioredoxin interacting protein | 0.0298477 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0296056 |
| PFN1 | profilin 1 | 0.0292667 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.02894 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0288656 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0287922 |
| RPL11 | ribosomal protein L11 | 0.0280251 |
| RPS19 | ribosomal protein S19 | 0.0275905 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0274123 |
| RGS2 | regulator of G-protein signaling 2 | 0.02728 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0272607 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0271874 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0271318 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.0270744 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0270101 |
| CENPF | centromere protein F, 350/400kDa | 0.026948 |
| RPL37 | ribosomal protein L37 | 0.0265439 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0260597 |
| ANXA1 | annexin A1 | 0.0257755 |
| UBXN4 | UBX domain protein 4 | 0.0256952 |
| RPS12 | ribosomal protein S12 | 0.025514 |
| TPI1 | triosephosphate isomerase 1 | 0.0246094 |
| RPS14 | ribosomal protein S14 | 0.0245926 |
| GPRIN3 | GPRIN family member 3 | 0.024564 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0243551 |
| RPS2 | ribosomal protein S2 | 0.0238202 |
| LAMB1 | laminin, beta 1 | 0.0237831 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0237511 |
| B2M | beta-2-microglobulin | 0.0234243 |
| CLU | clusterin | 0.0233921 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0233908 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0233696 |
| RPS4X | ribosomal protein S4, X-linked | 0.0232519 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0231582 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0230834 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.023042 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0229216 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0228919 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0228915 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0226509 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0223892 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0222931 |
| MT1X | metallothionein 1X | 0.0222271 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0221238 |
| PRKD3 | protein kinase D3 | 0.0218253 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0216428 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0216078 |
| MYADM | myeloid-associated differentiation marker | 0.0215582 |
| H3-3B | H3.3 histone B | 0.0214678 |
| RAD51B | RAD51 paralog B | 0.021298 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.349869 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.276425 |
| PTMA | prothymosin, alpha | -0.158112 |
| CANX | calnexin | -0.114789 |
| ASPH | aspartate beta-hydroxylase | -0.112142 |
| RPS27A | ribosomal protein S27a | -0.0871298 |
| UBC | ubiquitin C | -0.0715868 |
| TMSB10 | thymosin beta 10 | -0.0711867 |
| AHNAK | AHNAK nucleoprotein | -0.0671186 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0645273 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0622252 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0621536 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0592511 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0588933 |
| VCL | vinculin | -0.0573216 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0566042 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0535186 |
| OGA | O-GlcNAcase | -0.0532551 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0477463 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0474628 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.046905 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0437516 |
| RPS24 | ribosomal protein S24 | -0.0413217 |
| HDLBP | high density lipoprotein binding protein | -0.0407784 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0406526 |
| APP | amyloid beta (A4) precursor protein | -0.0398011 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0360438 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.035576 |
| SQSTM1 | sequestosome 1 | -0.0354365 |
| RPL4 | ribosomal protein L4 | -0.035019 |
| HLA-B | major histocompatibility complex, class I, B | -0.0349332 |
| RPL35A | ribosomal protein L35a | -0.0345259 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0344401 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0343942 |
| CDH13 | cadherin 13 | -0.0340778 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.033869 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.0337156 |
| DENND1A | DENN/MADD domain containing 1A | -0.0330122 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0328063 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0328049 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.032594 |
| FUS | FUS RNA binding protein | -0.0324465 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0321882 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.0314974 |
| INTS6 | integrator complex subunit 6 | -0.0314166 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0309303 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0305708 |
| VIM | vimentin | -0.0304487 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0301373 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0298985 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.029782 |
| RPL34 | ribosomal protein L34 | -0.0296938 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0295231 |
| CALR | calreticulin | -0.0293421 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0288072 |
| ENO1 | enolase 1, (alpha) | -0.0286015 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0283448 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0282042 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0279546 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0278773 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.027754 |
| MATR3 | matrin 3 | -0.0275017 |
| SPAG9 | sperm associated antigen 9 | -0.0273794 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0269955 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0266989 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0264846 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0261279 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0260493 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0259826 |
| MAP4 | microtubule-associated protein 4 | -0.0252158 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0251647 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0251412 |
| PARD3 | par-3 family cell polarity regulator | -0.0250882 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0247974 |
| UBAP2L | ubiquitin associated protein 2-like | -0.0247151 |
| PCNX4 | pecanex 4 | -0.024486 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0243103 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0240889 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0240681 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0239539 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0239367 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0235388 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0232803 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0232304 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0232099 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0230621 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0230429 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0228593 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0228171 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0227734 |
| USP3 | ubiquitin specific peptidase 3 | -0.0227176 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.0226486 |
| PLCB4 | phospholipase C, beta 4 | -0.0226084 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -0.0224505 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0223596 |
| WDR45B | WD repeat domain 45B | -0.0222511 |
| TFRC | transferrin receptor | -0.0222051 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0222047 |
| RPL38 | ribosomal protein L38 | -0.0222035 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.0221649 |
