Ciclopirox_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ciclopirox_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.168494
TPT1 tumor protein, translationally-controlled 1 0.129748
PDGFC platelet derived growth factor C 0.0868801
PDE4D phosphodiesterase 4D, cAMP-specific 0.0696292
RPL37A ribosomal protein L37a 0.0585085
RPS8 ribosomal protein S8 0.058149
DUSP4 dual specificity phosphatase 4 0.0577368
NAV2 neuron navigator 2 0.055548
RPS12 ribosomal protein S12 0.055054
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0536426
HDAC9 histone deacetylase 9 0.0518662
RPL23 ribosomal protein L23 0.0516665
RPL9 ribosomal protein L9 0.0514893
PRELID2 PRELI domain containing 2 0.0513553
PKM pyruvate kinase, muscle 0.0493452
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0478399
RPS6 ribosomal protein S6 0.0466027
RPS23 ribosomal protein S23 0.0464099
ENO2 enolase 2 (gamma, neuronal) 0.0460932
TMEM65 transmembrane protein 65 0.0442723
EIF1 eukaryotic translation initiation factor 1 0.0432452
NAP1L1 nucleosome assembly protein 1-like 1 0.0428203
RAB27B RAB27B, member RAS oncogene family 0.0426605
RPS13 ribosomal protein S13 0.0414368
TJP1 tight junction protein 1 0.0414079
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0413889
RPL31 ribosomal protein L31 0.0410923
ARL4C ADP-ribosylation factor-like 4C 0.0408566
SMC4 structural maintenance of chromosomes 4 0.0406282
MKI67 marker of proliferation Ki-67 0.039261
RPL11 ribosomal protein L11 0.0384805
RPLP2 ribosomal protein, large, P2 0.038308
RPL7A ribosomal protein L7a 0.0379786
CENPF centromere protein F, 350/400kDa 0.0378688
ANKRD12 ankyrin repeat domain 12 0.0376709
LOXL3 lysyl oxidase-like 3 0.0374329
FNIP1 folliculin interacting protein 1 0.0370186
SFPQ splicing factor proline/glutamine-rich 0.0361294
HJURP Holliday junction recognition protein 0.036037
TUBB4B tubulin, beta 4B class IVb 0.0354316
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0350892
RPL37 ribosomal protein L37 0.0347158
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0345765
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0339342
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0330999
ASPH aspartate beta-hydroxylase 0.0313124
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0309912
RPL26 ribosomal protein L26 0.0308828
INTS6 integrator complex subunit 6 0.0308267
GSE1 Gse1 coiled-coil protein 0.0304366
NCEH1 neutral cholesterol ester hydrolase 1 0.0302363
AHCYL2 adenosylhomocysteinase-like 2 0.029768
MACROD2 MACRO domain containing 2 0.0293783
RPL3 ribosomal protein L3 0.0289101
SRRM2 serine/arginine repetitive matrix 2 0.0288406
S100A9 S100 calcium binding protein A9 0.0283159
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0281272
B2M beta-2-microglobulin 0.0281105
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0280007
FOXN3 forkhead box N3 0.0279427
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0276187
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0276182
ZNF608 zinc finger protein 608 0.0275035
RPS17 ribosomal protein S17 0.0274316
DIAPH3 diaphanous-related formin 3 0.0270643
DSCAM Down syndrome cell adhesion molecule 0.0269044
MT2A metallothionein 2A 0.0268652
APLP2 amyloid beta (A4) precursor-like protein 2 0.0268301
KIF16B kinesin family member 16B 0.0266053
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0260349
RPL36 ribosomal protein L36 0.0260015
ANLN anillin, actin binding protein 0.0256312
AMOTL2 angiomotin like 2 0.025251
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0252014
TSC22D1 TSC22 domain family, member 1 0.025053
EIF5 eukaryotic translation initiation factor 5 0.0250207
KLF6 Kruppel-like factor 6 0.0247163
ACTG1 actin gamma 1 0.0246641
RPS27 ribosomal protein S27 0.024636
RPS10 ribosomal protein S10 0.0246203
KLF3 Kruppel-like factor 3 (basic) 0.0237743
MYH9 myosin, heavy chain 9, non-muscle 0.0237038
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0235224
PRPF38B pre-mRNA processing factor 38B 0.0234734
PGK1 phosphoglycerate kinase 1 0.0234577
RPS25 ribosomal protein S25 0.0234018
FOXK1 forkhead box K1 0.0230604
RPLP0 ribosomal protein, large, P0 0.0230032
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.022975
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0229636
UBC ubiquitin C 0.0228741
RCOR1 REST corepressor 1 0.0228568
RPS3 ribosomal protein S3 0.0228208
CAMTA1 calmodulin binding transcription activator 1 0.02269
KMT2C lysine (K)-specific methyltransferase 2C 0.0225641
TRIOBP TRIO and F-actin binding protein 0.0225042
MYL12B myosin, light chain 12B, regulatory 0.0221294
BCAS3 breast carcinoma amplified sequence 3 0.0220535
BRD2 bromodomain containing 2 0.0219617
TPX2 TPX2, microtubule-associated 0.0219581

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.206484
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.179359
AHNAK AHNAK nucleoprotein -0.130286
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0978569
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0920989
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0917349
DLG1 discs, large homolog 1 (Drosophila) -0.0848563
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0833049
TMSB4X thymosin beta 4, X-linked -0.0757569
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0752025
SSBP2 single-stranded DNA binding protein 2 -0.0743058
PDE4B phosphodiesterase 4B, cAMP-specific -0.0676022
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0648584
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0612299
FOXP1 forkhead box P1 -0.0606585
RBM39 RNA binding motif protein 39 -0.0577273
NFIA nuclear factor I/A -0.05751
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0555142
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.055288
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0506593
ZNF438 zinc finger protein 438 -0.0506285
GPHN gephyrin -0.0500026
FBXO11 F-box protein 11 -0.0475419
EML4 echinoderm microtubule associated protein like 4 -0.0463
TCF12 transcription factor 12 -0.0459138
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0454529
PTMA prothymosin, alpha -0.0448722
RPL4 ribosomal protein L4 -0.0415348
MAP4 microtubule-associated protein 4 -0.0396173
KDM3A lysine (K)-specific demethylase 3A -0.0393538
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0392382
ANXA1 annexin A1 -0.0382186
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0358207
KMT2E lysine (K)-specific methyltransferase 2E -0.0357443
VCL vinculin -0.0356717
RAB1A RAB1A, member RAS oncogene family -0.0355682
LOC112694756 uncharaterized LOC112694756 -0.0353655
USP3 ubiquitin specific peptidase 3 -0.0352599
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0352211
TRERF1 transcriptional regulating factor 1 -0.0348235
LDHA lactate dehydrogenase A -0.0347444
EVI5 ecotropic viral integration site 5 -0.0345471
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0345171
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0334596
RTN4 reticulon 4 -0.0328588
GARS1 glycyl-tRNA synthetase 1 -0.0327046
CDC73 cell division cycle 73 -0.03265
PDIA3 protein disulfide isomerase family A, member 3 -0.0323358
FAF1 Fas (TNFRSF6) associated factor 1 -0.0322577
NAMPT nicotinamide phosphoribosyltransferase -0.0320343
TXNRD1 thioredoxin reductase 1 -0.0315125
CAMKMT calmodulin-lysine N-methyltransferase -0.0311351
ITSN1 intersectin 1 (SH3 domain protein) -0.0307967
ANKRD11 ankyrin repeat domain 11 -0.0303393
ZMYND8 zinc finger, MYND-type containing 8 -0.0303289
GOLGA4 golgin A4 -0.029419
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0292962
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.028868
RLF rearranged L-myc fusion -0.0287147
APP amyloid beta (A4) precursor protein -0.0286144
CCND1 cyclin D1 -0.0284937
ZNF292 zinc finger protein 292 -0.0281612
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0278901
RAB7A RAB7A, member RAS oncogene family -0.0278861
SEC24D SEC24 family member D -0.0277583
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0276522
U2SURP U2 snRNP-associated SURP domain containing -0.0272323
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0270525
ACACA acetyl-CoA carboxylase alpha -0.0268953
KPNB1 karyopherin (importin) beta 1 -0.0268102
ZFAND3 zinc finger, AN1-type domain 3 -0.0259381
S100A6 S100 calcium binding protein A6 -0.0258319
WDR45B WD repeat domain 45B -0.0254937
LARS1 leucyl-tRNA synthetase 1 -0.0254822
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0254286
KIF5B kinesin family member 5B -0.0254166
TMEM263 transmembrane protein 263 -0.0250898
YBX1 Y box binding protein 1 -0.0248437
NEBL nebulette -0.0247984
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.024771
DUSP6 dual specificity phosphatase 6 -0.0246797
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0244928
TMEM123 transmembrane protein 123 -0.0243385
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0243254
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.02414
HDLBP high density lipoprotein binding protein -0.0240537
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0237859
FNDC3B fibronectin type III domain containing 3B -0.0237295
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0235221
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0235041
MSI2 musashi RNA-binding protein 2 -0.023403
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0232222
SFXN1 sideroflexin 1 -0.0231229
GNAS GNAS complex locus -0.0231054
RAB6A RAB6A, member RAS oncogene family -0.023006
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0230058
MIS18BP1 MIS18 binding protein 1 -0.0229951
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0226401
SPIDR scaffolding protein involved in DNA repair -0.0225776
RNF145 ring finger protein 145 -0.0225269