Ciclopirox_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ciclopirox perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ciclopirox_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.176024
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.170387
IGFBP3 insulin-like growth factor binding protein 3 0.161843
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.134618
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.113656
B2M beta-2-microglobulin 0.0648365
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.063983
ERBIN erbb2 interacting protein 0.0610039
MYH9 myosin, heavy chain 9, non-muscle 0.0609903
FNDC3B fibronectin type III domain containing 3B 0.0597386
PKM pyruvate kinase, muscle 0.0595796
KYNU kynureninase 0.0540007
RNF145 ring finger protein 145 0.0536211
IGFBP7 insulin-like growth factor binding protein 7 0.0527701
RTN4 reticulon 4 0.0527221
LDHA lactate dehydrogenase A 0.0526538
MSN moesin 0.052586
SMAD3 SMAD family member 3 0.0522331
CALD1 caldesmon 1 0.0493516
H3-3B H3.3 histone B 0.049159
CDK6 cyclin-dependent kinase 6 0.0488053
CD44 CD44 molecule (Indian blood group) 0.0479217
ARRDC3 arrestin domain containing 3 0.0460071
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0438027
TPM2 tropomyosin 2 (beta) 0.043502
IL6ST interleukin 6 signal transducer 0.0425815
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0416768
KTN1 kinectin 1 (kinesin receptor) 0.0412671
RAB1A RAB1A, member RAS oncogene family 0.0410785
EXT1 exostosin glycosyltransferase 1 0.039083
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0390189
MED13L mediator complex subunit 13-like 0.0389017
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0387339
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0387219
SFPQ splicing factor proline/glutamine-rich 0.0386646
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0378669
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.036791
KMT2E lysine (K)-specific methyltransferase 2E 0.0365437
VEGFC vascular endothelial growth factor C 0.0354305
COL6A3 collagen, type VI, alpha 3 0.0353244
RPS12 ribosomal protein S12 0.0347512
COL1A1 collagen, type I, alpha 1 0.0347373
EGR1 early growth response 1 0.0342084
TXNIP thioredoxin interacting protein 0.0340194
RPS6 ribosomal protein S6 0.0332533
ANKRD11 ankyrin repeat domain 11 0.0331874
EPAS1 endothelial PAS domain protein 1 0.0328623
CSDE1 cold shock domain containing E1, RNA-binding 0.0326737
DST dystonin 0.0322733
PDLIM5 PDZ and LIM domain 5 0.0317972
APLP2 amyloid beta (A4) precursor-like protein 2 0.0315762
VCL vinculin 0.0314299
RPS14 ribosomal protein S14 0.0313974
GLS2 glutaminase 2 (liver, mitochondrial) 0.0313443
SRRM2 serine/arginine repetitive matrix 2 0.0312601
SDC2 syndecan 2 0.0311316
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0305377
MTPN myotrophin 0.0302334
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0296379
ECE1 endothelin converting enzyme 1 0.0296355
TM9SF4 transmembrane 9 superfamily protein member 4 0.0296032
RICTOR RPTOR independent companion of MTOR, complex 2 0.0295871
SRPK2 SRSF protein kinase 2 0.0295651
NF1 neurofibromin 1 0.0295174
MKI67 marker of proliferation Ki-67 0.029356
MACF1 microtubule-actin crosslinking factor 1 0.0291537
ANKRD17 ankyrin repeat domain 17 0.0289262
IGFBP5 insulin-like growth factor binding protein 5 0.0286613
TNIP1 TNFAIP3 interacting protein 1 0.0286307
ITGAV integrin, alpha V 0.0284698
SP100 SP100 nuclear antigen 0.0284344
ANKRD12 ankyrin repeat domain 12 0.0284081
C1D C1D nuclear receptor corepressor 0.0281611
ADM adrenomedullin 0.0279079
XRN2 5'-3' exoribonuclease 2 0.0278844
KDM6A lysine (K)-specific demethylase 6A 0.0273455
MT1X metallothionein 1X 0.0272968
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0271095
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0271081
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0269667
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0268231
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0264986
BCAR3 breast cancer anti-estrogen resistance 3 0.0262803
RPL9 ribosomal protein L9 0.0262797
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0262372
TPT1 tumor protein, translationally-controlled 1 0.0258043
VIM vimentin 0.0257878
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0257403
FOSL1 FOS-like antigen 1 0.0256651
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0255971
MYADM myeloid-associated differentiation marker 0.0255709
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0253952
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0252975
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0251416
JARID2 jumonji, AT rich interactive domain 2 0.0248932
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0248016
TRA2A transformer 2 alpha homolog (Drosophila) 0.0247524
ANKRD28 ankyrin repeat domain 28 0.0247396
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0246558
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0246019

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.255748
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.17396
CDH13 cadherin 13 -0.129362
AHNAK AHNAK nucleoprotein -0.108112
FN1 fibronectin 1 -0.0951301
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0858017
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0782219
TPM4 tropomyosin 4 -0.0664578
COL6A2 collagen, type VI, alpha 2 -0.065069
RAI14 retinoic acid induced 14 -0.0587908
LOX lysyl oxidase -0.0552502
PDIA4 protein disulfide isomerase family A, member 4 -0.0551335
SDC4 syndecan 4 -0.0529759
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0492658
RAD51B RAD51 paralog B -0.0479968
NRXN3 neurexin 3 -0.0468756
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0463204
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0463086
BACE2 beta-site APP-cleaving enzyme 2 -0.046179
KMT2C lysine (K)-specific methyltransferase 2C -0.0461458
CHD9 chromodomain helicase DNA binding protein 9 -0.0460599
SEC24D SEC24 family member D -0.0449255
ZMYND8 zinc finger, MYND-type containing 8 -0.0447106
CANX calnexin -0.0439777
HDLBP high density lipoprotein binding protein -0.0426326
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0424753
TENT5A terminal nucleotidyltransferase 5A -0.0404086
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0402948
FRMD6 FERM domain containing 6 -0.0398115
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0396835
SPDYA speedy/RINGO cell cycle regulator family member A -0.0388994
HLA-B major histocompatibility complex, class I, B -0.0388574
FTH1 ferritin, heavy polypeptide 1 -0.0373295
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.036623
CALU calumenin -0.0359252
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0356036
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0354411
SMYD3 SET and MYND domain containing 3 -0.0351094
AKAP9 A kinase (PRKA) anchor protein 9 -0.0343307
HLA-A major histocompatibility complex, class I, A -0.0333808
COG6 component of oligomeric golgi complex 6 -0.0331977
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0315741
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0309735
AFF3 AF4/FMR2 family, member 3 -0.0308235
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0307986
GOLGA3 golgin A3 -0.0307049
PRELID2 PRELI domain containing 2 -0.0306881
PGK1 phosphoglycerate kinase 1 -0.030443
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0302804
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0300031
SEC31A SEC31 homolog A (S. cerevisiae) -0.0299991
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0294124
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0292471
HMGA2 high mobility group AT-hook 2 -0.0291646
PDIA3 protein disulfide isomerase family A, member 3 -0.0291479
TMSB10 thymosin beta 10 -0.0291054
MYOF myoferlin -0.0287579
PDE4D phosphodiesterase 4D, cAMP-specific -0.0281046
EXOC4 exocyst complex component 4 -0.0280658
GOLGA4 golgin A4 -0.0279451
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0277566
PTMA prothymosin, alpha -0.0276983
MON2 MON2 homolog (S. cerevisiae) -0.0273522
MXI1 MAX interactor 1, dimerization protein -0.0272918
HJURP Holliday junction recognition protein -0.0272902
ELL2 elongation factor, RNA polymerase II, 2 -0.0272831
PDIA5 protein disulfide isomerase family A, member 5 -0.0269186
TAS2R14 taste receptor, type 2, member 14 -0.0267198
IL6 interleukin 6 -0.0266816
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.025941
IARS1 isoleucyl-tRNA synthetase 1 -0.0258579
HLA-C major histocompatibility complex, class I, C -0.025782
COL5A1 collagen, type V, alpha 1 -0.02554
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0253167
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0252687
HM13 histocompatibility (minor) 13 -0.0252243
HIP1 huntingtin interacting protein 1 -0.0250426
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0248695
NDE1 nudE neurodevelopment protein 1 -0.0246188
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0240406
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0240124
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0239878
UGDH UDP-glucose 6-dehydrogenase -0.0238862
ITCH itchy E3 ubiquitin protein ligase -0.0238659
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0236637
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0235737
SSR1 signal sequence receptor, alpha -0.0234305
COL7A1 collagen, type VII, alpha 1 -0.0233426
DIAPH3 diaphanous-related formin 3 -0.0232106
TPR translocated promoter region, nuclear basket protein -0.0231253
APOLD1 apolipoprotein L domain containing 1 -0.0230676
GPR173 G protein-coupled receptor 173 -0.0229483
LMAN1 lectin, mannose-binding, 1 -0.0228529
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0227203
FLNB filamin B, beta -0.022616
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0225751
GNAS GNAS complex locus -0.0225313
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0225264
CLINT1 clathrin interactor 1 -0.0225197
ARF4 ADP-ribosylation factor 4 -0.0225194