Cilostazol_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.118795
MT2A metallothionein 2A 0.1031
LOXL2 lysyl oxidase-like 2 0.0995439
CD44 CD44 molecule (Indian blood group) 0.0868202
PODXL podocalyxin-like 0.0851438
FBN1 fibrillin 1 0.0844668
AKAP12 A kinase (PRKA) anchor protein 12 0.0778695
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0752483
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0684005
VEGFA vascular endothelial growth factor A 0.0677869
BHLHE40 basic helix-loop-helix family, member e40 0.0649759
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0552647
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0496348
FNDC3B fibronectin type III domain containing 3B 0.0456568
TNIP1 TNFAIP3 interacting protein 1 0.0448715
FLNB filamin B, beta 0.0448317
OPTN optineurin 0.044398
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0425203
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0421253
DPYSL3 dihydropyrimidinase-like 3 0.0420398
C1D C1D nuclear receptor corepressor 0.0419837
MYH9 myosin, heavy chain 9, non-muscle 0.0407706
THBS2 thrombospondin 2 0.0401553
ATP13A3 ATPase type 13A3 0.0399333
CLU clusterin 0.0374347
OGA O-GlcNAcase 0.0370692
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0368907
ZFP36L1 ZFP36 ring finger protein-like 1 0.036633
ARRDC3 arrestin domain containing 3 0.0363883
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0357049
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0356046
PRRC2C proline-rich coiled-coil 2C 0.0348619
RUNX1 runt-related transcription factor 1 0.0345151
TRIO trio Rho guanine nucleotide exchange factor 0.0340472
SQSTM1 sequestosome 1 0.0333279
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0330121
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0328633
CYLD cylindromatosis (turban tumor syndrome) 0.0317548
ZMIZ1 zinc finger, MIZ-type containing 1 0.0313156
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0310431
APP amyloid beta (A4) precursor protein 0.0306162
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0304902
DST dystonin 0.0299761
WTAP Wilms tumor 1 associated protein 0.0296734
MXI1 MAX interactor 1, dimerization protein 0.0294262
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0292938
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0292712
SBF2 SET binding factor 2 0.0292168
B2M beta-2-microglobulin 0.0290075
WDFY1 WD repeat and FYVE domain containing 1 0.0289425
GPC6 glypican 6 0.0288786
SLC22A23 solute carrier family 22, member 23 0.0288765
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0288684
MATR3 matrin 3 0.0288576
SRRM2 serine/arginine repetitive matrix 2 0.028625
NAMPT nicotinamide phosphoribosyltransferase 0.0277498
LDHA lactate dehydrogenase A 0.0276734
DDIT4 DNA-damage-inducible transcript 4 0.0276322
FTH1 ferritin, heavy polypeptide 1 0.0276287
FMNL2 formin-like 2 0.0272328
CCL5 chemokine (C-C motif) ligand 5 0.0268728
NFE2L1 nuclear factor, erythroid 2-like 1 0.0268258
UBC ubiquitin C 0.0262979
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0254458
IQGAP1 IQ motif containing GTPase activating protein 1 0.025176
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0249407
RNF145 ring finger protein 145 0.0248202
EEF2 eukaryotic translation elongation factor 2 0.0248052
FLNA filamin A, alpha 0.0246587
EIF4H eukaryotic translation initiation factor 4H 0.0245613
HLA-B major histocompatibility complex, class I, B 0.0244907
SOD2 superoxide dismutase 2, mitochondrial 0.0243939
RPS3 ribosomal protein S3 0.0243931
ELL2 elongation factor, RNA polymerase II, 2 0.0238205
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0238047
KLF6 Kruppel-like factor 6 0.023774
SFTPA2 surfactant protein A2 0.0237096
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0237094
L1CAM L1 cell adhesion molecule 0.0233584
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0233488
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0230959
MYOF myoferlin 0.0230094
KDM3A lysine (K)-specific demethylase 3A 0.022983
STC1 stanniocalcin 1 0.022968
PRPF8 pre-mRNA processing factor 8 0.0227389
ADAM17 ADAM metallopeptidase domain 17 0.0226927
COL1A2 collagen, type I, alpha 2 0.0226763
GOLGA4 golgin A4 0.0223827
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0217059
ABI1 abl-interactor 1 0.0216776
KMT2E lysine (K)-specific methyltransferase 2E 0.021502
UBAP2L ubiquitin associated protein 2-like 0.0213949
GLS2 glutaminase 2 (liver, mitochondrial) 0.021235
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0210024
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0209609
NT5C2 5'-nucleotidase, cytosolic II 0.0209152
MB21D2 Mab-21 domain containing 2 0.020832
ADM adrenomedullin 0.020532
USP9X ubiquitin specific peptidase 9, X-linked 0.0204554
HILPDA hypoxia inducible lipid droplet-associated 0.0203436

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.1724
IGFBP3 insulin-like growth factor binding protein 3 -0.122733
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0981519
CDH13 cadherin 13 -0.0807661
PLAT plasminogen activator, tissue -0.0741211
AHNAK AHNAK nucleoprotein -0.0731576
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0730268
S100A10 S100 calcium binding protein A10 -0.0594032
SLC39A11 solute carrier family 39, member 11 -0.0555696
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0546706
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0528824
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0527204
S100A6 S100 calcium binding protein A6 -0.0520436
SUCNR1 succinate receptor 1 -0.0477832
ABI3BP ABI family, member 3 (NESH) binding protein -0.0444343
FN1 fibronectin 1 -0.0434129
EFNA5 ephrin-A5 -0.0427256
PBX3 pre-B-cell leukemia homeobox 3 -0.0395957
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0351227
TPT1 tumor protein, translationally-controlled 1 -0.0348025
POTEF POTE ankyrin domain family, member F -0.0338446
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0332204
CANX calnexin -0.0322783
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0308119
RIGI RNA sensor RIG-I -0.0296709
DGKG diacylglycerol kinase, gamma 90kDa -0.0289869
ASPH aspartate beta-hydroxylase -0.0286125
EGFR epidermal growth factor receptor -0.02797
SLC38A1 solute carrier family 38, member 1 -0.0273077
FLT1 fms-related tyrosine kinase 1 -0.0271697
CUX1 cut-like homeobox 1 -0.0263436
RPL35A ribosomal protein L35a -0.0260329
TPM4 tropomyosin 4 -0.0257412
CYTH3 cytohesin 3 -0.0253057
SORBS2 sorbin and SH3 domain containing 2 -0.0251187
VDAC1 voltage-dependent anion channel 1 -0.0246716
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0241213
LOC112694756 uncharaterized LOC112694756 -0.0240642
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0238727
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0235562
SP100 SP100 nuclear antigen -0.022589
VCL vinculin -0.0221469
RASAL2 RAS protein activator like 2 -0.0219465
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0218458
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0218053
EXT1 exostosin glycosyltransferase 1 -0.0217525
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0214826
DOCK5 dedicator of cytokinesis 5 -0.0213684
ALCAM activated leukocyte cell adhesion molecule -0.0210032
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0208465
KRT81 keratin 81, type II -0.020595
FSTL1 follistatin-like 1 -0.0205879
RPS24 ribosomal protein S24 -0.0203456
INTS6 integrator complex subunit 6 -0.0202261
MCL1 myeloid cell leukemia 1 -0.0200839
HM13 histocompatibility (minor) 13 -0.0200566
PDE4D phosphodiesterase 4D, cAMP-specific -0.0200498
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0199592
ZBTB20 zinc finger and BTB domain containing 20 -0.0199517
LRRC17 leucine rich repeat containing 17 -0.0197456
CD59 CD59 molecule, complement regulatory protein -0.0193596
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0192978
SPDL1 spindle apparatus coiled-coil protein 1 -0.0191903
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0191498
CDK13 cyclin-dependent kinase 13 -0.0191077
MAP1B microtubule-associated protein 1B -0.0189751
COL5A1 collagen, type V, alpha 1 -0.0188633
PRSS23 protease, serine, 23 -0.0188283
CCND1 cyclin D1 -0.0188108
JMJD1C jumonji domain containing 1C -0.018469
TBCA tubulin folding cofactor A -0.0183837
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0182829
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0182594
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0182455
HLA-C major histocompatibility complex, class I, C -0.0179106
CTSD cathepsin D -0.0177982
IARS1 isoleucyl-tRNA synthetase 1 -0.0170775
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0170238
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0169107
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.016908
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0166449
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0166133
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0164467
LMNA lamin A/C -0.016373
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0163453
HDAC9 histone deacetylase 9 -0.016318
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0162652
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0161308
DIAPH3 diaphanous-related formin 3 -0.015672
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0156259
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0156196
CEP112 centrosomal protein 112kDa -0.0155006
ADAM32 ADAM metallopeptidase domain 32 -0.015478
FMN2 formin 2 -0.0153886
RPLP1 ribosomal protein, large, P1 -0.0152781
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0152568
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0152383
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0152361
SEPTIN7 septin 7 -0.0150663
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0149779