Cilostazol_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.1156
RPL23 ribosomal protein L23 0.111948
PTMA prothymosin, alpha 0.0976202
RPS6 ribosomal protein S6 0.0799572
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0702706
VEGFA vascular endothelial growth factor A 0.0689263
EEF2 eukaryotic translation elongation factor 2 0.0674984
IGF2 insulin-like growth factor 2 0.0581597
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0558721
ACTG1 actin gamma 1 0.0501961
RPS12 ribosomal protein S12 0.0489525
RPLP1 ribosomal protein, large, P1 0.0480633
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.047025
MATR3 matrin 3 0.0439385
RPL38 ribosomal protein L38 0.0438502
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0428247
SET SET nuclear proto-oncogene 0.0420811
ZMIZ1 zinc finger, MIZ-type containing 1 0.040635
RPS3 ribosomal protein S3 0.0404399
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0400556
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0399995
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.039864
TBX2 T-box 2 0.039705
RNF213 ring finger protein 213 0.0370023
TRIB2 tribbles pseudokinase 2 0.0361945
RPL19 ribosomal protein L19 0.0350386
RPS19 ribosomal protein S19 0.0344631
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0342536
RPL37A ribosomal protein L37a 0.0342184
DDIT4 DNA-damage-inducible transcript 4 0.033705
RPL26 ribosomal protein L26 0.0322585
HSPA8 heat shock 70kDa protein 8 0.0321674
CSDE1 cold shock domain containing E1, RNA-binding 0.0318417
FAM13A family with sequence similarity 13, member A 0.031623
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0305196
B2M beta-2-microglobulin 0.0302154
RPL36 ribosomal protein L36 0.0293974
RPS29 ribosomal protein S29 0.0293301
NAMPT nicotinamide phosphoribosyltransferase 0.0289062
RPL27 ribosomal protein L27 0.0288628
TRIO trio Rho guanine nucleotide exchange factor 0.0283835
RPL34 ribosomal protein L34 0.0283068
RPS17 ribosomal protein S17 0.028296
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0278626
SQSTM1 sequestosome 1 0.0278567
TMSB10 thymosin beta 10 0.0278335
RPS27A ribosomal protein S27a 0.0275816
RPL11 ribosomal protein L11 0.0267368
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0265442
MEIS2 Meis homeobox 2 0.026294
RPS27 ribosomal protein S27 0.0262595
PRRC2C proline-rich coiled-coil 2C 0.0260473
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0256825
RPS2 ribosomal protein S2 0.0255771
WAC WW domain containing adaptor with coiled-coil 0.0254119
RPS21 ribosomal protein S21 0.0253739
TPT1 tumor protein, translationally-controlled 1 0.0252657
PNN pinin, desmosome associated protein 0.0248209
POTEF POTE ankyrin domain family, member F 0.0244993
H3-3B H3.3 histone B 0.0243096
RAD23B RAD23 homolog B (S. cerevisiae) 0.02429
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0240593
RPL35A ribosomal protein L35a 0.0239357
FTL ferritin, light polypeptide 0.0237154
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0236811
EEF1G eukaryotic translation elongation factor 1 gamma 0.0233686
RPS5 ribosomal protein S5 0.0228014
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0227844
RPS10 ribosomal protein S10 0.02271
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0225078
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0224587
RPL7 ribosomal protein L7 0.0223841
RACK1 receptor for activated C kinase 1 0.022315
RPL9 ribosomal protein L9 0.0222373
RPL7A ribosomal protein L7a 0.0222115
RPL28 ribosomal protein L28 0.0220376
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0219837
COL1A1 collagen, type I, alpha 1 0.0219517
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0218918
NACA nascent polypeptide-associated complex alpha subunit 0.0215853
FOXO3 forkhead box O3 0.0215329
SRRM2 serine/arginine repetitive matrix 2 0.0214389
LMNA lamin A/C 0.0212603
MYH9 myosin, heavy chain 9, non-muscle 0.0212521
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0208893
WDR43 WD repeat domain 43 0.0207403
MDK midkine (neurite growth-promoting factor 2) 0.0207087
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0205561
GATA3 GATA binding protein 3 0.020443
HAS2 hyaluronan synthase 2 0.0202235
S100A9 S100 calcium binding protein A9 0.0199665
RPS15 ribosomal protein S15 0.0199646
RPL32 ribosomal protein L32 0.0198776
RPL12 ribosomal protein L12 0.019561
RPLP0 ribosomal protein, large, P0 0.0194069
DSCAM Down syndrome cell adhesion molecule 0.0192546
ADAR adenosine deaminase, RNA-specific 0.0192423
ZC3H13 zinc finger CCCH-type containing 13 0.0190453
RPS23 ribosomal protein S23 0.0190019
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.0189096

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.18257
AKAP12 A kinase (PRKA) anchor protein 12 -0.0983635
LIMCH1 LIM and calponin homology domains 1 -0.089266
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0747427
ZBTB20 zinc finger and BTB domain containing 20 -0.0740692
GDF15 growth differentiation factor 15 -0.0647889
NALF1 NALCN channel auxiliary factor 1 -0.0618482
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0608929
CEMIP cell migration inducing protein, hyaluronan binding -0.0539344
SYT1 synaptotagmin I -0.0537043
GPC5 glypican 5 -0.0520669
STC1 stanniocalcin 1 -0.0518861
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0504999
MAML2 mastermind-like 2 (Drosophila) -0.0500883
COL4A5 collagen, type IV, alpha 5 -0.0496258
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0475072
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0473605
SOS1 son of sevenless homolog 1 (Drosophila) -0.0466207
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0466203
VCL vinculin -0.0445304
PLAT plasminogen activator, tissue -0.0439792
AHR aryl hydrocarbon receptor -0.0436462
EXT1 exostosin glycosyltransferase 1 -0.0426121
EXOC4 exocyst complex component 4 -0.04192
BPTF bromodomain PHD finger transcription factor -0.0393476
SEC31A SEC31 homolog A (S. cerevisiae) -0.039193
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0386592
ZNF804A zinc finger protein 804A -0.0386558
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0383281
MACF1 microtubule-actin crosslinking factor 1 -0.0375219
DLG1 discs, large homolog 1 (Drosophila) -0.0370805
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0368741
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0366076
THSD4 thrombospondin, type I, domain containing 4 -0.0358701
ITPRID2 ITPR interacting domain containing 2 -0.0353802
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0346285
BICD1 bicaudal D homolog 1 (Drosophila) -0.0336907
MCL1 myeloid cell leukemia 1 -0.0336382
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0335218
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0329496
COPA coatomer protein complex, subunit alpha -0.0329425
HMGA2 high mobility group AT-hook 2 -0.0324881
NBEA neurobeachin -0.0319698
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0317254
PSD3 pleckstrin and Sec7 domain containing 3 -0.0316757
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0314555
KDM5B lysine (K)-specific demethylase 5B -0.0312973
NCAM2 neural cell adhesion molecule 2 -0.0310126
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0308938
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0304418
ATRNL1 attractin-like 1 -0.0302706
ANGPT1 angiopoietin 1 -0.0301701
CDH13 cadherin 13 -0.0298362
KCNIP4 Kv channel interacting protein 4 -0.0297986
PTPRM protein tyrosine phosphatase, receptor type, M -0.0291963
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0291522
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0289169
USP34 ubiquitin specific peptidase 34 -0.0288482
SLC38A2 solute carrier family 38, member 2 -0.0286698
MEF2A myocyte enhancer factor 2A -0.0281911
PRKCA protein kinase C, alpha -0.0278547
CADM2 cell adhesion molecule 2 -0.0278264
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0275755
MBTD1 mbt domain containing 1 -0.0275706
EPAS1 endothelial PAS domain protein 1 -0.0273937
LPP LIM domain containing preferred translocation partner in lipoma -0.0273012
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0268139
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0268119
DIAPH2 diaphanous-related formin 2 -0.0267206
DPH6 diphthamine biosynthesis 6 -0.0263784
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0261357
PTPRD protein tyrosine phosphatase, receptor type, D -0.0261134
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0254878
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.02535
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0252888
VMP1 vacuole membrane protein 1 -0.025153
IGFBP3 insulin-like growth factor binding protein 3 -0.0250454
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0248596
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0246226
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0242629
AKAP13 A kinase (PRKA) anchor protein 13 -0.0241715
MAP1B microtubule-associated protein 1B -0.0241007
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0239907
AFF3 AF4/FMR2 family, member 3 -0.0239048
ZNF638 zinc finger protein 638 -0.0237004
ATM ATM serine/threonine kinase -0.0236906
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.023409
FNIP1 folliculin interacting protein 1 -0.0233925
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.023382
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0233502
ITGA1 integrin, alpha 1 -0.0231801
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0227196
NCOA7 nuclear receptor coactivator 7 -0.0226637
RPTOR regulatory associated protein of MTOR, complex 1 -0.0226102
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0225696
KDM2A lysine (K)-specific demethylase 2A -0.0224105
SETD5 SET domain containing 5 -0.0222543
SRP54 signal recognition particle 54kDa -0.0219939
ZNF609 zinc finger protein 609 -0.0219933
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0217627