Cilostazol_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.119575
MT2A metallothionein 2A 0.0629447
PTMA prothymosin, alpha 0.059569
TSC22D1 TSC22 domain family, member 1 0.0522303
SRRM2 serine/arginine repetitive matrix 2 0.0497047
RPL23 ribosomal protein L23 0.0493287
RPS3 ribosomal protein S3 0.0442927
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0420018
CST3 cystatin C 0.0419948
MLPH melanophilin 0.0415871
RPL37A ribosomal protein L37a 0.0405976
ARRDC3 arrestin domain containing 3 0.0391487
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0386192
MYH9 myosin, heavy chain 9, non-muscle 0.0385305
LDHA lactate dehydrogenase A 0.0381184
SORBS1 sorbin and SH3 domain containing 1 0.036843
RPS6 ribosomal protein S6 0.0367467
PADI1 peptidyl arginine deiminase, type I 0.0362883
PRRC2C proline-rich coiled-coil 2C 0.0358854
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0354871
HPCAL1 hippocalcin-like 1 0.0340006
RPS12 ribosomal protein S12 0.0335597
HLA-B major histocompatibility complex, class I, B 0.031803
RPS19 ribosomal protein S19 0.0306867
RPL9 ribosomal protein L9 0.0303208
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0300343
ARGLU1 arginine and glutamate rich 1 0.0298146
TBC1D22A TBC1 domain family, member 22A 0.0296064
FAT1 FAT atypical cadherin 1 0.0292623
RBM25 RNA binding motif protein 25 0.0290522
TMSB10 thymosin beta 10 0.0277559
FTL ferritin, light polypeptide 0.0277036
EEF2 eukaryotic translation elongation factor 2 0.0272708
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0268815
BHLHE40 basic helix-loop-helix family, member e40 0.0262589
RPS29 ribosomal protein S29 0.0255643
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0254393
PTPRF protein tyrosine phosphatase, receptor type, F 0.0254134
NDRG1 N-myc downstream regulated 1 0.0253851
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0252592
RPL21 ribosomal protein L21 0.0249728
SMAD3 SMAD family member 3 0.0248063
SHB Src homology 2 domain containing adaptor protein B 0.0244863
B2M beta-2-microglobulin 0.0244516
OARD1 O-acyl-ADP-ribose deacylase 1 0.0243932
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0242937
BRWD3 bromodomain and WD repeat domain containing 3 0.0240554
RPLP2 ribosomal protein, large, P2 0.0239608
RPL26 ribosomal protein L26 0.0237737
MATR3 matrin 3 0.02367
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0227854
PDIA6 protein disulfide isomerase family A, member 6 0.0227467
DNM2 dynamin 2 0.0226363
IFNGR1 interferon gamma receptor 1 0.0226146
RPL7A ribosomal protein L7a 0.0225368
ZBTB7A zinc finger and BTB domain containing 7A 0.0224978
IFI6 interferon, alpha-inducible protein 6 0.0224744
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.022337
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0222097
EIF4B eukaryotic translation initiation factor 4B 0.021952
PRELID2 PRELI domain containing 2 0.021843
RNF149 ring finger protein 149 0.021786
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0217101
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0214974
NCOR2 nuclear receptor corepressor 2 0.0214145
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0211035
RPL30 ribosomal protein L30 0.020842
ZMIZ1 zinc finger, MIZ-type containing 1 0.0206596
HYOU1 hypoxia up-regulated 1 0.0204831
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0203984
RNF43 ring finger protein 43 0.0202091
EGFR epidermal growth factor receptor 0.0201035
CMIP c-Maf inducing protein 0.0200497
RPL36 ribosomal protein L36 0.0199738
PRPF8 pre-mRNA processing factor 8 0.0199073
PNN pinin, desmosome associated protein 0.0195303
KIF16B kinesin family member 16B 0.0193255
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0191301
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0191064
GSK3B glycogen synthase kinase 3 beta 0.0188858
CTTN cortactin 0.0187663
ITGB4 integrin, beta 4 0.018707
ENO2 enolase 2 (gamma, neuronal) 0.018617
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0184927
BCL2L1 BCL2-like 1 0.0183554
RAD51B RAD51 paralog B 0.0183302
APOL2 apolipoprotein L, 2 0.0183117
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0183099
TM4SF1 transmembrane 4 L six family member 1 0.0180109
RACK1 receptor for activated C kinase 1 0.0179302
DIAPH1 diaphanous-related formin 1 0.017921
ANXA4 annexin A4 0.0177777
MYO10 myosin X 0.0175738
GIGYF2 GRB10 interacting GYF protein 2 0.0175143
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0175072
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.0174372
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 0.0173997
EFHD2 EF-hand domain family, member D2 0.0173431
STS steroid sulfatase (microsomal), isozyme S 0.0172825
VIM vimentin 0.0172017

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.238855
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.139738
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.132097
EZR ezrin -0.128317
MACC1 metastasis associated in colon cancer 1 -0.110031
MYO1E myosin IE -0.107342
EGR1 early growth response 1 -0.0935591
SQSTM1 sequestosome 1 -0.0915918
MBNL2 muscleblind-like splicing regulator 2 -0.086622
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0813339
IRF1 interferon regulatory factor 1 -0.0804615
TPT1 tumor protein, translationally-controlled 1 -0.0774953
TMC5 transmembrane channel-like 5 -0.0762796
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0759117
GCLC glutamate-cysteine ligase, catalytic subunit -0.0738522
ANXA2 annexin A2 -0.0735611
AHI1 Abelson helper integration site 1 -0.0699671
PERP PERP, TP53 apoptosis effector -0.0691057
RHOBTB3 Rho-related BTB domain containing 3 -0.0688405
EPSTI1 epithelial stromal interaction 1 (breast) -0.068142
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0676132
PLSCR1 phospholipid scramblase 1 -0.0670522
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0642273
SEC31A SEC31 homolog A (S. cerevisiae) -0.0642232
CANX calnexin -0.0608345
MORF4L2 mortality factor 4 like 2 -0.0604019
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0558097
EXT1 exostosin glycosyltransferase 1 -0.0556793
MX2 MX dynamin-like GTPase 2 -0.0547654
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.053925
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0538236
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0529887
JUN jun proto-oncogene -0.0529701
UGDH UDP-glucose 6-dehydrogenase -0.051387
RAB1A RAB1A, member RAS oncogene family -0.0503112
RIGI RNA sensor RIG-I -0.0500438
SPATA13 spermatogenesis associated 13 -0.0499269
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0497647
ZBTB20 zinc finger and BTB domain containing 20 -0.0491964
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0489756
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0488202
ITPKC inositol-trisphosphate 3-kinase C -0.0486226
HLA-E major histocompatibility complex, class I, E -0.0463815
PHACTR4 phosphatase and actin regulator 4 -0.0460495
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0460344
GOLGB1 golgin B1 -0.0457609
MAP7 microtubule-associated protein 7 -0.0449024
TJP1 tight junction protein 1 -0.0448431
ITGA6 integrin, alpha 6 -0.0447955
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0447577
UBC ubiquitin C -0.0444244
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0443934
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0442485
SERINC5 serine incorporator 5 -0.0440111
UBL3 ubiquitin-like 3 -0.0438879
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0431954
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0427815
LOC102724023 ES1 protein homolog, mitochondrial -0.0424016
EIF1 eukaryotic translation initiation factor 1 -0.0418441
LOC112694756 uncharaterized LOC112694756 -0.0417342
MX1 MX dynamin-like GTPase 1 -0.0415895
BLZF1 basic leucine zipper nuclear factor 1 -0.0413569
SPDYA speedy/RINGO cell cycle regulator family member A -0.0401086
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0400445
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0397628
ADIPOR2 adiponectin receptor 2 -0.0395042
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0391955
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0391614
PDIA3 protein disulfide isomerase family A, member 3 -0.0391239
PHF3 PHD finger protein 3 -0.0389954
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0387588
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0387141
HDLBP high density lipoprotein binding protein -0.0384906
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0382911
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0377676
ATF6 activating transcription factor 6 -0.0376257
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0374697
RAB7A RAB7A, member RAS oncogene family -0.0373589
AHNAK AHNAK nucleoprotein -0.0370525
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0368319
NCOA7 nuclear receptor coactivator 7 -0.0361408
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0355374
FNIP2 folliculin interacting protein 2 -0.0349074
SPAG9 sperm associated antigen 9 -0.0348166
BTBD9 BTB (POZ) domain containing 9 -0.0345059
ANKRD10 ankyrin repeat domain 10 -0.0344529
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0338776
RBM47 RNA binding motif protein 47 -0.0337675
SDC4 syndecan 4 -0.0337075
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0326261
SLC38A2 solute carrier family 38, member 2 -0.03262
DUSP10 dual specificity phosphatase 10 -0.0325067
MCU mitochondrial calcium uniporter -0.0324623
C3ORF52 chromosome 3 open reading frame 52 -0.0321049
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0320652
ARL5B ADP-ribosylation factor-like 5B -0.0320319
ABLIM1 actin binding LIM protein 1 -0.0320113
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0318732
NAMPT nicotinamide phosphoribosyltransferase -0.0318274
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0312713