Cilostazol_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.163944
COL6A3 collagen, type VI, alpha 3 0.107146
MT2A metallothionein 2A 0.0828484
CD44 CD44 molecule (Indian blood group) 0.0712273
MYH9 myosin, heavy chain 9, non-muscle 0.069888
LOXL2 lysyl oxidase-like 2 0.0303064
BHLHE40 basic helix-loop-helix family, member e40 0.0277987
COL5A1 collagen, type V, alpha 1 0.0268923
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0265098
COL7A1 collagen, type VII, alpha 1 0.0263325
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0243099
EEF2 eukaryotic translation elongation factor 2 0.0238368
RPS3 ribosomal protein S3 0.0231445
CSF1 colony stimulating factor 1 (macrophage) 0.0231378
PLEC plectin 0.0217213
ARRDC3 arrestin domain containing 3 0.0213531
SMAD3 SMAD family member 3 0.0213394
FAT1 FAT atypical cadherin 1 0.0202888
TRIO trio Rho guanine nucleotide exchange factor 0.0200086
APP amyloid beta (A4) precursor protein 0.0193554
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0191317
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0188804
HSPA8 heat shock 70kDa protein 8 0.0187582
FLNA filamin A, alpha 0.0175791
RPL23 ribosomal protein L23 0.0173832
RPS19 ribosomal protein S19 0.0171211
RPL37A ribosomal protein L37a 0.0159052
ACTG1 actin gamma 1 0.0158663
INHBA inhibin, beta A 0.0156483
CST3 cystatin C 0.0156214
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0153519
TIMP1 TIMP metallopeptidase inhibitor 1 0.0152001
IER3 immediate early response 3 0.0145505
CDH13 cadherin 13 0.0145382
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0145002
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0139471
CTSB cathepsin B 0.0139439
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0138883
TNS1 tensin 1 0.0137207
TNIP1 TNFAIP3 interacting protein 1 0.0136213
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0135879
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0134786
FTL ferritin, light polypeptide 0.0133311
RPL36 ribosomal protein L36 0.0132014
NAMPT nicotinamide phosphoribosyltransferase 0.0131158
MSN moesin 0.0130534
EGFR epidermal growth factor receptor 0.013039
MACF1 microtubule-actin crosslinking factor 1 0.0126145
RPS8 ribosomal protein S8 0.0125982
RPS18 ribosomal protein S18 0.0125634
RPS12 ribosomal protein S12 0.0122609
RACK1 receptor for activated C kinase 1 0.0121342
SFTPA2 surfactant protein A2 0.0120465
IFI6 interferon, alpha-inducible protein 6 0.011945
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0117026
EXT1 exostosin glycosyltransferase 1 0.0116987
LDHA lactate dehydrogenase A 0.0116018
RPL12 ribosomal protein L12 0.011507
SHB Src homology 2 domain containing adaptor protein B 0.0114058
NAV1 neuron navigator 1 0.0113742
RPS17 ribosomal protein S17 0.0113386
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0112777
RUNX1 runt-related transcription factor 1 0.0112466
JAG1 jagged 1 0.0112175
KIAA1217 KIAA1217 0.0111075
RPL7 ribosomal protein L7 0.0110509
PTMA prothymosin, alpha 0.0109836
BRD2 bromodomain containing 2 0.0109769
RPS6 ribosomal protein S6 0.0108027
ZMIZ1 zinc finger, MIZ-type containing 1 0.0107539
RPL18 ribosomal protein L18 0.01052
JARID2 jumonji, AT rich interactive domain 2 0.0104964
EIF4H eukaryotic translation initiation factor 4H 0.0103238
COL6A2 collagen, type VI, alpha 2 0.010273
MYO10 myosin X 0.0101361
SSR1 signal sequence receptor, alpha 0.0100363
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0100329
OAZ1 ornithine decarboxylase antizyme 1 0.00995972
CXCL3 chemokine (C-X-C motif) ligand 3 0.00992433
HLA-B major histocompatibility complex, class I, B 0.00990806
ATXN1 ataxin 1 0.00988078
COL4A2 collagen, type IV, alpha 2 0.00956641
NFE2L1 nuclear factor, erythroid 2-like 1 0.00925225
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.00923551
MTSS1 metastasis suppressor 1 0.00902701
AHDC1 AT hook, DNA binding motif, containing 1 0.00897864
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.00891023
ENO1 enolase 1, (alpha) 0.0089022
RPL26 ribosomal protein L26 0.00890041
RPS21 ribosomal protein S21 0.0088845
TMED9 transmembrane emp24 protein transport domain containing 9 0.00888357
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.00884323
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00878897
CALD1 caldesmon 1 0.00867014
RPL3 ribosomal protein L3 0.00865557
FBXL7 F-box and leucine-rich repeat protein 7 0.00862266
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00862146
ADAM12 ADAM metallopeptidase domain 12 0.00861266
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.00842656
TMSB10 thymosin beta 10 0.00833567

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.251309
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0802081
VIM vimentin -0.0783241
NDRG1 N-myc downstream regulated 1 -0.0716849
COL1A2 collagen, type I, alpha 2 -0.0577
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0467721
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0443013
CANX calnexin -0.0390712
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0373077
PSD3 pleckstrin and Sec7 domain containing 3 -0.0344536
LOX lysyl oxidase -0.0306537
FBN1 fibrillin 1 -0.0293048
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0276099
TRAM1 translocation associated membrane protein 1 -0.026032
GOLGA4 golgin A4 -0.0257563
COL1A1 collagen, type I, alpha 1 -0.0239581
LIMS1 LIM and senescent cell antigen-like domains 1 -0.023656
PTK2 protein tyrosine kinase 2 -0.023299
ZBTB20 zinc finger and BTB domain containing 20 -0.0232303
LMAN1 lectin, mannose-binding, 1 -0.022887
HMGA2 high mobility group AT-hook 2 -0.0216987
SPAG9 sperm associated antigen 9 -0.0205907
MAP4 microtubule-associated protein 4 -0.0192552
TPM4 tropomyosin 4 -0.0184956
AHNAK AHNAK nucleoprotein -0.0184733
DPYD dihydropyrimidine dehydrogenase -0.0183785
WASF2 WAS protein family, member 2 -0.0182828
TAPBP TAP binding protein (tapasin) -0.0180752
TMEM165 transmembrane protein 165 -0.0178045
POSTN periostin, osteoblast specific factor -0.0170263
VDAC1 voltage-dependent anion channel 1 -0.0169847
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0168169
ZFAND3 zinc finger, AN1-type domain 3 -0.0166799
RAB2A RAB2A, member RAS oncogene family -0.0166553
PRRC1 proline-rich coiled-coil 1 -0.0162583
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0158888
RAB1A RAB1A, member RAS oncogene family -0.0157478
PDIA3 protein disulfide isomerase family A, member 3 -0.0153867
SBF2 SET binding factor 2 -0.0153743
MTDH metadherin -0.0151656
NPEPPS aminopeptidase puromycin sensitive -0.0151442
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0150338
BIRC6 baculoviral IAP repeat containing 6 -0.014826
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.014743
ITCH itchy E3 ubiquitin protein ligase -0.0146461
F3 coagulation factor III (thromboplastin, tissue factor) -0.0145692
MYADM myeloid-associated differentiation marker -0.0144752
SEPTIN7 septin 7 -0.0142851
TTC3 tetratricopeptide repeat domain 3 -0.0142176
DLG1 discs, large homolog 1 (Drosophila) -0.0140187
COPB1 coatomer protein complex, subunit beta 1 -0.0139151
TGFBI transforming growth factor, beta-induced, 68kDa -0.0137857
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0137793
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0137073
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0134944
KCTD9 potassium channel tetramerization domain containing 9 -0.0134731
ASPH aspartate beta-hydroxylase -0.0134089
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0133725
NKTR natural killer cell triggering receptor -0.0131787
COPA coatomer protein complex, subunit alpha -0.0131334
GARS1 glycyl-tRNA synthetase 1 -0.0130998
RBM39 RNA binding motif protein 39 -0.013084
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0129744
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0129222
SKIC3 SKI3 subunit of superkiller complex -0.0128874
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0128702
SRP54 signal recognition particle 54kDa -0.012824
TFG TRK-fused gene -0.0127784
UBC ubiquitin C -0.0127747
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0126756
TRPS1 trichorhinophalangeal syndrome I -0.0125326
SEC31A SEC31 homolog A (S. cerevisiae) -0.0124246
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0123793
GLG1 golgi glycoprotein 1 -0.0123266
IARS1 isoleucyl-tRNA synthetase 1 -0.0123265
SEC24A SEC24 family member A -0.0121557
AKAP9 A kinase (PRKA) anchor protein 9 -0.01208
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0120781
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0118996
JMJD1C jumonji domain containing 1C -0.0118959
SPDYA speedy/RINGO cell cycle regulator family member A -0.0118888
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0118308
RPL35A ribosomal protein L35a -0.0117417
KMT2E lysine (K)-specific methyltransferase 2E -0.0116576
GOLGB1 golgin B1 -0.0115204
HIP1 huntingtin interacting protein 1 -0.0115077
EIF1 eukaryotic translation initiation factor 1 -0.0114298
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0113982
CLINT1 clathrin interactor 1 -0.0112815
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0112135
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0111046
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0109754
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.010933
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0108902
COG5 component of oligomeric golgi complex 5 -0.0107923
USP3 ubiquitin specific peptidase 3 -0.0107784
NOP58 NOP58 ribonucleoprotein -0.0106488
MARCHF6 membrane associated ring-CH-type finger 6 -0.0105821
ANTXR2 anthrax toxin receptor 2 -0.0105734
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0105516