Cilostazol_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.154567
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.100018
NAMPT nicotinamide phosphoribosyltransferase 0.0685525
VEGFA vascular endothelial growth factor A 0.068324
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0512552
SMAD3 SMAD family member 3 0.0494048
TGM2 transglutaminase 2 0.0387146
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0356812
NAV2 neuron navigator 2 0.0351438
RPS19 ribosomal protein S19 0.0322758
ANGPTL4 angiopoietin-like 4 0.0303883
CCNL1 cyclin L1 0.0300792
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0299223
EEF2 eukaryotic translation elongation factor 2 0.0293308
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0291044
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0245749
RPL23 ribosomal protein L23 0.0230127
POTEF POTE ankyrin domain family, member F 0.0224865
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0223004
HAS2 hyaluronan synthase 2 0.0215335
RAB27B RAB27B, member RAS oncogene family 0.0210573
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0201493
RPS6 ribosomal protein S6 0.0191819
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0190822
RUNX1 runt-related transcription factor 1 0.0179394
ECE1 endothelin converting enzyme 1 0.0178078
KLF6 Kruppel-like factor 6 0.0174732
MT1X metallothionein 1X 0.0173447
G0S2 G0/G1 switch 2 0.0172976
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0167726
ICAM1 intercellular adhesion molecule 1 0.016754
RPS12 ribosomal protein S12 0.0166972
RPL36 ribosomal protein L36 0.0166256
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0162704
MYO10 myosin X 0.0160118
MSN moesin 0.0157317
FOSL1 FOS-like antigen 1 0.0152168
KDM7A lysine (K)-specific demethylase 7A 0.0151875
RPS18 ribosomal protein S18 0.0150228
MEF2D myocyte enhancer factor 2D 0.0148487
ATP5MC2 ATP synthase membrane subunit c locus 2 0.0148381
CEP250 centrosomal protein 250kDa 0.0145806
CHD1L chromodomain helicase DNA binding protein 1-like 0.0143464
CDCP1 CUB domain containing protein 1 0.0135387
RPLP2 ribosomal protein, large, P2 0.0135347
YBX3 Y box binding protein 3 0.013503
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.013491
TLE3 transducin-like enhancer of split 3 0.0134028
EIF4H eukaryotic translation initiation factor 4H 0.0133126
BRD2 bromodomain containing 2 0.0132628
SEC61G Sec61 gamma subunit 0.0131336
SRRM2 serine/arginine repetitive matrix 2 0.0130952
CCNY cyclin Y 0.0128152
IL6 interleukin 6 0.0127963
CYB5R3 cytochrome b5 reductase 3 0.0127825
RPS23 ribosomal protein S23 0.0126928
RPL35A ribosomal protein L35a 0.0126852
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0126772
B2M beta-2-microglobulin 0.0125617
DUSP5 dual specificity phosphatase 5 0.0125513
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0124629
RPS13 ribosomal protein S13 0.0122746
RPS11 ribosomal protein S11 0.0122632
PLAUR plasminogen activator, urokinase receptor 0.0122014
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0119
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0118746
RPL30 ribosomal protein L30 0.011857
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0117896
INTS1 integrator complex subunit 1 0.0116671
FAM117B family with sequence similarity 117, member B 0.0116024
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.01156
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0115593
FAM219A family with sequence similarity 219, member A 0.0113889
PLPP3 phospholipid phosphatase 3 0.011298
RPL37A ribosomal protein L37a 0.0112887
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0112735
TRA2B transformer 2 beta homolog (Drosophila) 0.0112454
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.0112369
ARRDC3 arrestin domain containing 3 0.011145
CD47 CD47 molecule 0.0110494
RPS4X ribosomal protein S4, X-linked 0.0109688
WDR43 WD repeat domain 43 0.010804
MAST4 microtubule associated serine/threonine kinase family member 4 0.0107727
CCL20 chemokine (C-C motif) ligand 20 0.0107709
MINK1 misshapen-like kinase 1 0.0107295
FTL ferritin, light polypeptide 0.0107214
RPL7A ribosomal protein L7a 0.0106865
CAMTA1 calmodulin binding transcription activator 1 0.0106325
ERGIC3 ERGIC and golgi 3 0.0105947
MTCH1 mitochondrial carrier 1 0.0105681
PTBP3 polypyrimidine tract binding protein 3 0.0105197
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0105132
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0103808
RPL12 ribosomal protein L12 0.0103207
PCBP2 poly(rC) binding protein 2 0.0102818
PVR poliovirus receptor 0.0102382
PELI1 pellino E3 ubiquitin protein ligase 1 0.0101777
RPL35 ribosomal protein L35 0.0101444
RPS17 ribosomal protein S17 0.0101062
LUZP1 leucine zipper protein 1 0.0100956

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.230115
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.166422
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148726
PDE4D phosphodiesterase 4D, cAMP-specific -0.118133
IGFBP3 insulin-like growth factor binding protein 3 -0.0972412
FN1 fibronectin 1 -0.0887504
FNDC3B fibronectin type III domain containing 3B -0.087158
TRIO trio Rho guanine nucleotide exchange factor -0.080469
RAB1A RAB1A, member RAS oncogene family -0.0767224
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0743594
GRB10 growth factor receptor-bound protein 10 -0.0740277
LOX lysyl oxidase -0.0732031
PSD3 pleckstrin and Sec7 domain containing 3 -0.072369
GOLGA4 golgin A4 -0.0684427
GPC6 glypican 6 -0.066447
RBM39 RNA binding motif protein 39 -0.0660179
DLG1 discs, large homolog 1 (Drosophila) -0.0655592
RAI14 retinoic acid induced 14 -0.0653162
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0646492
HMGA2 high mobility group AT-hook 2 -0.0637264
KDM2A lysine (K)-specific demethylase 2A -0.0611161
CANX calnexin -0.0596838
DPYD dihydropyrimidine dehydrogenase -0.0588825
SOD2 superoxide dismutase 2, mitochondrial -0.0573463
SEC31A SEC31 homolog A (S. cerevisiae) -0.056849
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0566606
AKAP12 A kinase (PRKA) anchor protein 12 -0.0554813
LMAN1 lectin, mannose-binding, 1 -0.0544585
TAS2R14 taste receptor, type 2, member 14 -0.0542917
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0515016
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0494977
NCOA7 nuclear receptor coactivator 7 -0.0478809
EXT1 exostosin glycosyltransferase 1 -0.0474775
DST dystonin -0.0471208
MAP1B microtubule-associated protein 1B -0.0463634
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0455491
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0450728
FAM20C family with sequence similarity 20, member C -0.0440321
OXSR1 oxidative stress responsive 1 -0.0438733
DSCAM Down syndrome cell adhesion molecule -0.0428915
GLCCI1 glucocorticoid induced 1 -0.0422939
HDLBP high density lipoprotein binding protein -0.0420173
USP34 ubiquitin specific peptidase 34 -0.0418957
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0415527
KYNU kynureninase -0.0414386
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0409887
JMJD1C jumonji domain containing 1C -0.0407387
PDLIM5 PDZ and LIM domain 5 -0.0401854
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0401077
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0396124
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0392996
EHBP1 EH domain binding protein 1 -0.0391453
MEF2A myocyte enhancer factor 2A -0.0389597
SEC24A SEC24 family member A -0.038952
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0385566
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0384114
MRPS6 mitochondrial ribosomal protein S6 -0.038393
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0381286
RAD51B RAD51 paralog B -0.0377375
PTMA prothymosin, alpha -0.0376014
VCL vinculin -0.0375466
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0373433
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0370624
ANKRD28 ankyrin repeat domain 28 -0.0363769
AOPEP aminopeptidase O (putative) -0.0363403
DDIT3 DNA-damage-inducible transcript 3 -0.0359244
MON2 MON2 homolog (S. cerevisiae) -0.0357464
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0354942
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0346756
UBE2H ubiquitin-conjugating enzyme E2H -0.0344819
NF1 neurofibromin 1 -0.0344265
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0344024
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0343138
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0341999
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0341528
AHNAK AHNAK nucleoprotein -0.034011
FBXO11 F-box protein 11 -0.0337414
COPA coatomer protein complex, subunit alpha -0.0333944
MORF4L2 mortality factor 4 like 2 -0.0333916
ZEB2 zinc finger E-box binding homeobox 2 -0.0333235
SRP54 signal recognition particle 54kDa -0.0331644
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0330953
BLZF1 basic leucine zipper nuclear factor 1 -0.0329937
SOS1 son of sevenless homolog 1 (Drosophila) -0.0329675
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0328627
ZNF804A zinc finger protein 804A -0.0327712
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0327692
RAP1B RAP1B, member of RAS oncogene family -0.0326861
SYT1 synaptotagmin I -0.0324385
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0322875
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0319511
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0319229
ADD3 adducin 3 (gamma) -0.0318699
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0318196
FNIP1 folliculin interacting protein 1 -0.0314903
GREB1L growth regulation by estrogen in breast cancer-like -0.0313992
NTN4 netrin 4 -0.0308761
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0308414
TTC3 tetratricopeptide repeat domain 3 -0.0307227
NPEPPS aminopeptidase puromycin sensitive -0.0307076