Cilostazol_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.247183
NDRG1 N-myc downstream regulated 1 0.19371
AKAP12 A kinase (PRKA) anchor protein 12 0.170772
PRRC2C proline-rich coiled-coil 2C 0.10157
RPS3 ribosomal protein S3 0.101447
EIF1 eukaryotic translation initiation factor 1 0.100372
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0889888
VEGFA vascular endothelial growth factor A 0.0865823
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0864696
RPS19 ribosomal protein S19 0.0848555
BHLHE40 basic helix-loop-helix family, member e40 0.0823614
RPS6 ribosomal protein S6 0.0817064
VIM vimentin 0.0799049
HLA-B major histocompatibility complex, class I, B 0.0741871
FAM13A family with sequence similarity 13, member A 0.0736693
RPL26 ribosomal protein L26 0.0732663
HOOK2 hook microtubule-tethering protein 2 0.0705993
FLNB filamin B, beta 0.069618
RPLP1 ribosomal protein, large, P1 0.0672031
B2M beta-2-microglobulin 0.0661415
MT2A metallothionein 2A 0.0635959
IGFBP5 insulin-like growth factor binding protein 5 0.0633475
GNAS GNAS complex locus 0.0629647
RPS27A ribosomal protein S27a 0.0628853
FNDC3A fibronectin type III domain containing 3A 0.0625705
GOLGA4 golgin A4 0.0604725
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0595238
GARS1 glycyl-tRNA synthetase 1 0.0584226
RPL19 ribosomal protein L19 0.0583662
SEC31A SEC31 homolog A (S. cerevisiae) 0.0570652
WSB1 WD repeat and SOCS box containing 1 0.0559393
TPT1 tumor protein, translationally-controlled 1 0.0533915
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0524777
HELZ helicase with zinc finger 0.0494813
S100A10 S100 calcium binding protein A10 0.0494642
TMSB10 thymosin beta 10 0.0487832
KDM6A lysine (K)-specific demethylase 6A 0.0486271
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.048325
IGF2 insulin-like growth factor 2 0.046573
FTL ferritin, light polypeptide 0.0463993
FAM162A family with sequence similarity 162, member A 0.046236
FAT1 FAT atypical cadherin 1 0.0454042
RPL12 ribosomal protein L12 0.0442958
EEF2 eukaryotic translation elongation factor 2 0.0425493
RPL7A ribosomal protein L7a 0.0423663
RPL11 ribosomal protein L11 0.041674
IFIH1 interferon induced with helicase C domain 1 0.0409607
ELL2 elongation factor, RNA polymerase II, 2 0.0376553
BACE2 beta-site APP-cleaving enzyme 2 0.0371685
RAB1A RAB1A, member RAS oncogene family 0.0368
ZNF292 zinc finger protein 292 0.0347731
FNDC3B fibronectin type III domain containing 3B 0.0346357
PDE4D phosphodiesterase 4D, cAMP-specific 0.0336588
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0318472
OGA O-GlcNAcase 0.0314516
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.031387
PGK1 phosphoglycerate kinase 1 0.0306271
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0305066
DSCAM Down syndrome cell adhesion molecule 0.0293758
LDHA lactate dehydrogenase A 0.0292572
RPS8 ribosomal protein S8 0.0285652
ENO1 enolase 1, (alpha) 0.0275835
STC1 stanniocalcin 1 0.0274244
KMT2C lysine (K)-specific methyltransferase 2C 0.0264562
PDIA3 protein disulfide isomerase family A, member 3 0.0262882
CCNI cyclin I 0.0256164
PDE10A phosphodiesterase 10A 0.0254315
PTK2 protein tyrosine kinase 2 0.0223129
PSD3 pleckstrin and Sec7 domain containing 3 0.0214821
ANKRD11 ankyrin repeat domain 11 0.0214349
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0213785
MMP1 matrix metallopeptidase 1 0.0209678
AFDN afadin, adherens junction formation factor 0.0207832
KDM3A lysine (K)-specific demethylase 3A 0.0203781
SMAD3 SMAD family member 3 0.0202007
RBM25 RNA binding motif protein 25 0.0194211
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0187968
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0176117
RPL35A ribosomal protein L35a 0.0171796
MXD1 MAX dimerization protein 1 0.0171372
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0170283
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0169909
AKAP9 A kinase (PRKA) anchor protein 9 0.0168848
ERRFI1 ERBB receptor feedback inhibitor 1 0.0163186
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0161658
PUM2 pumilio RNA-binding family member 2 0.0157147
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0145181
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0137226
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0129997
ZFAND3 zinc finger, AN1-type domain 3 0.0123384
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0115196
SETD5 SET domain containing 5 0.0109313
NPTN neuroplastin 0.0105466
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0103722
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.00904462
NKD1 naked cuticle homolog 1 (Drosophila) 0.00814324
WNK1 WNK lysine deficient protein kinase 1 0.00797722
KTN1 kinectin 1 (kinesin receptor) 0.00738077
CALD1 caldesmon 1 0.00720505
PTMA prothymosin, alpha 0.00574027

decreased expression

Symbol Name Standardized Value
SLTM SAFB-like, transcription modulator -0.20504
EGFR epidermal growth factor receptor -0.156634
TXNRD1 thioredoxin reductase 1 -0.11976
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0866432
DPYD dihydropyrimidine dehydrogenase -0.0829414
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0795059
ZBTB20 zinc finger and BTB domain containing 20 -0.0783739
WASF2 WAS protein family, member 2 -0.0746732
PARD3 par-3 family cell polarity regulator -0.0689386
CD44 CD44 molecule (Indian blood group) -0.067385
JMJD1C jumonji domain containing 1C -0.0668423
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0639307
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0635428
SPAG9 sperm associated antigen 9 -0.061978
KRT17 keratin 17, type I -0.0604731
ANXA2 annexin A2 -0.0604109
LAMB3 laminin, beta 3 -0.0600624
COL6A3 collagen, type VI, alpha 3 -0.0599628
GSK3B glycogen synthase kinase 3 beta -0.0590505
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0584612
SAMD4A sterile alpha motif domain containing 4A -0.0584157
MYO1E myosin IE -0.0572222
CUX1 cut-like homeobox 1 -0.0566154
TTC3 tetratricopeptide repeat domain 3 -0.0562483
VCL vinculin -0.0552602
GPC6 glypican 6 -0.0544187
SMYD3 SET and MYND domain containing 3 -0.0537482
KYNU kynureninase -0.0536855
MED13L mediator complex subunit 13-like -0.053333
TMEM165 transmembrane protein 165 -0.0499528
CHD1 chromodomain helicase DNA binding protein 1 -0.0488489
VMP1 vacuole membrane protein 1 -0.0471982
TRIO trio Rho guanine nucleotide exchange factor -0.0469177
FAF1 Fas (TNFRSF6) associated factor 1 -0.0468187
RNF145 ring finger protein 145 -0.0451463
POTEF POTE ankyrin domain family, member F -0.04493
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0445226
MED13 mediator complex subunit 13 -0.0444587
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0444155
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0440634
NIPBL Nipped-B homolog (Drosophila) -0.0432722
ANXA1 annexin A1 -0.0428505
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0417302
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0399056
EXT1 exostosin glycosyltransferase 1 -0.0395937
LRP12 low density lipoprotein receptor-related protein 12 -0.0391924
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0384762
INHBA inhibin, beta A -0.0373216
LSAMP limbic system-associated membrane protein -0.0372349
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0370077
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0345834
OSMR oncostatin M receptor -0.0345557
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0338345
DST dystonin -0.0332674
ERBIN erbb2 interacting protein -0.0329843
USP34 ubiquitin specific peptidase 34 -0.0328701
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0326887
SBF2 SET binding factor 2 -0.0326121
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0312662
ADGRB3 adhesion G protein-coupled receptor B3 -0.0310729
TJP1 tight junction protein 1 -0.0310044
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0305085
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0300198
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0293607
CSNK1A1 casein kinase 1, alpha 1 -0.029322
BRWD1 bromodomain and WD repeat domain containing 1 -0.0290989
EGR1 early growth response 1 -0.0289957
CMIP c-Maf inducing protein -0.0288566
SQSTM1 sequestosome 1 -0.0287878
PDE8A phosphodiesterase 8A -0.0282715
LMO7 LIM domain 7 -0.0279674
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.027739
NALF1 NALCN channel auxiliary factor 1 -0.0275193
CEMIP cell migration inducing protein, hyaluronan binding -0.0264372
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0263188
SCAF11 SR-related CTD-associated factor 11 -0.0263089
PRELID2 PRELI domain containing 2 -0.024912
SRRM2 serine/arginine repetitive matrix 2 -0.0241592
FMNL2 formin-like 2 -0.0239856
RUNX1 runt-related transcription factor 1 -0.0237101
AFF1 AF4/FMR2 family, member 1 -0.0235639
TRA2A transformer 2 alpha homolog (Drosophila) -0.022689
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0207006
UPP1 uridine phosphorylase 1 -0.0206772
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0206498
RANBP2 RAN binding protein 2 -0.020598
ANKRD17 ankyrin repeat domain 17 -0.0205278
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0204192
KDM4C lysine (K)-specific demethylase 4C -0.0200741
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0197633
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.01966
ARHGAP26 Rho GTPase activating protein 26 -0.0192194
CLTC clathrin, heavy chain (Hc) -0.0190911
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0189869
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0189451
KMT2E lysine (K)-specific methyltransferase 2E -0.0174733
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0174674
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0172216
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0168776
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0165646