Cilostazol_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.134298
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.114653
RPL37A ribosomal protein L37a 0.0975128
EEF2 eukaryotic translation elongation factor 2 0.0917349
TMSB10 thymosin beta 10 0.0899
RPL23 ribosomal protein L23 0.0698081
AKAP12 A kinase (PRKA) anchor protein 12 0.0649948
PTMA prothymosin, alpha 0.0625972
RPL26 ribosomal protein L26 0.058105
THSD4 thrombospondin, type I, domain containing 4 0.055403
TRIO trio Rho guanine nucleotide exchange factor 0.0553684
UBAP2L ubiquitin associated protein 2-like 0.0545493
RPS12 ribosomal protein S12 0.0536575
RPS21 ribosomal protein S21 0.0535603
RPS19 ribosomal protein S19 0.0531722
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0521241
RPL36 ribosomal protein L36 0.0506925
ACTG1 actin gamma 1 0.0505414
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0503126
RACK1 receptor for activated C kinase 1 0.0497417
RAD51B RAD51 paralog B 0.049105
CSDE1 cold shock domain containing E1, RNA-binding 0.0455483
PLEC plectin 0.0453939
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0442364
SMAD3 SMAD family member 3 0.043789
RPL34 ribosomal protein L34 0.0437199
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0428718
RPL13A ribosomal protein L13a 0.0418639
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.040797
RPS27A ribosomal protein S27a 0.0403164
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0402879
RPS8 ribosomal protein S8 0.0390443
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0385575
RPS4X ribosomal protein S4, X-linked 0.0385476
WDR43 WD repeat domain 43 0.0385207
MARCHF4 membrane associated ring-CH-type finger 4 0.038275
HSPA8 heat shock 70kDa protein 8 0.0380921
RPL18 ribosomal protein L18 0.0377806
EIF4B eukaryotic translation initiation factor 4B 0.0377452
RPL11 ribosomal protein L11 0.0376394
RPL5 ribosomal protein L5 0.0375087
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0370526
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0368471
GRAMD1B GRAM domain containing 1B 0.0368366
RPL31 ribosomal protein L31 0.0368244
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0367776
MYH9 myosin, heavy chain 9, non-muscle 0.0365807
FTL ferritin, light polypeptide 0.0365328
NACA nascent polypeptide-associated complex alpha subunit 0.0363886
RPS29 ribosomal protein S29 0.0354582
RPLP1 ribosomal protein, large, P1 0.0344212
RPS10 ribosomal protein S10 0.0342264
RPS18 ribosomal protein S18 0.0331336
DENND1A DENN/MADD domain containing 1A 0.0328965
RPS27 ribosomal protein S27 0.0322335
OAZ1 ornithine decarboxylase antizyme 1 0.0320625
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0314924
SHB Src homology 2 domain containing adaptor protein B 0.0313416
MACF1 microtubule-actin crosslinking factor 1 0.0311445
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0310911
CTTN cortactin 0.0310652
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0310628
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0310581
IGF2 insulin-like growth factor 2 0.0310272
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0309555
GSTP1 glutathione S-transferase pi 1 0.0303544
ARID1A AT rich interactive domain 1A (SWI-like) 0.0301412
KDM3A lysine (K)-specific demethylase 3A 0.0296876
RPL38 ribosomal protein L38 0.0295786
CAVIN1 caveolae associated protein 1 0.0294616
RPL12 ribosomal protein L12 0.0292517
RPL37 ribosomal protein L37 0.0292356
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0284193
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0283289
USP22 ubiquitin specific peptidase 22 0.0282057
KRT18 keratin 18, type I 0.0281473
ANKRD11 ankyrin repeat domain 11 0.0275252
ACTN1 actinin, alpha 1 0.0269456
MT2A metallothionein 2A 0.0267234
FLNA filamin A, alpha 0.0265668
S100A11 S100 calcium binding protein A11 0.0263918
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0262559
H1-0 H1.0 linker histone 0.0256731
NAMPT nicotinamide phosphoribosyltransferase 0.0256324
RPL27 ribosomal protein L27 0.0255841
PDE4D phosphodiesterase 4D, cAMP-specific 0.0253634
EIF4H eukaryotic translation initiation factor 4H 0.0252341
RPL7A ribosomal protein L7a 0.0250846
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0247992
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0247345
PTPRF protein tyrosine phosphatase, receptor type, F 0.0241102
FUS FUS RNA binding protein 0.0237304
CEP250 centrosomal protein 250kDa 0.0235393
SFPQ splicing factor proline/glutamine-rich 0.0234123
FKBP4 FK506 binding protein 4, 59kDa 0.0231656
SEC61G Sec61 gamma subunit 0.0231252
RPL19 ribosomal protein L19 0.023088
ZC3H13 zinc finger CCCH-type containing 13 0.0230461
RPL32 ribosomal protein L32 0.0228953
LIF leukemia inhibitory factor 0.0228419

decreased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.100995
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.095517
VIM vimentin -0.0725424
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0699058
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.066596
PCBP2 poly(rC) binding protein 2 -0.0558061
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0537137
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0535847
TFPI2 tissue factor pathway inhibitor 2 -0.0526323
KTN1 kinectin 1 (kinesin receptor) -0.0507603
VDAC1 voltage-dependent anion channel 1 -0.0470518
UBE2H ubiquitin-conjugating enzyme E2H -0.0465225
SMC4 structural maintenance of chromosomes 4 -0.0435524
JMJD1C jumonji domain containing 1C -0.0420773
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0407926
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0407613
POTEF POTE ankyrin domain family, member F -0.039832
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0397835
KDM2A lysine (K)-specific demethylase 2A -0.0396203
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0386046
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0379788
EGR1 early growth response 1 -0.0371965
STC1 stanniocalcin 1 -0.0368256
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0364171
DIAPH3 diaphanous-related formin 3 -0.0351184
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0347694
SETD5 SET domain containing 5 -0.0338384
NIPBL Nipped-B homolog (Drosophila) -0.0333716
PDIA3 protein disulfide isomerase family A, member 3 -0.0327956
XPO1 exportin 1 -0.0303196
TUBA1B tubulin, alpha 1b -0.0301055
CCNL1 cyclin L1 -0.0295019
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0271693
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0271396
NOP58 NOP58 ribonucleoprotein -0.0271147
BBX bobby sox homolog (Drosophila) -0.0271028
KMT5B lysine methyltransferase 5B -0.0269944
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0268685
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0266247
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0259244
PHF20 PHD finger protein 20 -0.0258169
ERBIN erbb2 interacting protein -0.0253395
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.0252116
YAP1 Yes-associated protein 1 -0.0251008
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0250511
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.025015
RB1CC1 RB1-inducible coiled-coil 1 -0.024833
CD2AP CD2-associated protein -0.0246308
AKAP9 A kinase (PRKA) anchor protein 9 -0.0245184
PFN1 profilin 1 -0.024433
CANX calnexin -0.0243597
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0243208
NKTR natural killer cell triggering receptor -0.0242769
CEP192 centrosomal protein 192kDa -0.0240084
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0238642
CAMKMT calmodulin-lysine N-methyltransferase -0.0237573
RAB22A RAB22A, member RAS oncogene family -0.0237172
TAOK1 TAO kinase 1 -0.023471
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0234481
ZNF148 zinc finger protein 148 -0.0232728
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0232618
SEPTIN7 septin 7 -0.0228295
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0224275
MIS18BP1 MIS18 binding protein 1 -0.0224156
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0223601
MMP12 matrix metallopeptidase 12 -0.0222026
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0220266
TBK1 TANK-binding kinase 1 -0.0219688
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0216052
ZBTB20 zinc finger and BTB domain containing 20 -0.0216036
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0215622
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0215442
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0214006
CENPF centromere protein F, 350/400kDa -0.0212442
SGO2 shugoshin 2 -0.0212172
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0211806
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0211639
UBC ubiquitin C -0.0211329
TPM3 tropomyosin 3 -0.0210117
STXBP3 syntaxin binding protein 3 -0.0209411
ASXL2 additional sex combs like transcriptional regulator 2 -0.0207001
FUBP1 far upstream element (FUSE) binding protein 1 -0.0204779
FNIP1 folliculin interacting protein 1 -0.0204209
SNX27 sorting nexin family member 27 -0.0202796
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0201352
DEK DEK proto-oncogene -0.0199249
AAK1 AP2 associated kinase 1 -0.019892
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0197806
ZNF292 zinc finger protein 292 -0.0197634
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0196581
AVL9 AVL9 homolog (S. cerevisiase) -0.0196276
USP34 ubiquitin specific peptidase 34 -0.0195786
DSTN destrin (actin depolymerizing factor) -0.0191552
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0191315
SERBP1 SERPINE1 mRNA binding protein 1 -0.0190297
UBN2 ubinuclein 2 -0.0190022
FBXO11 F-box protein 11 -0.0189677
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0189465
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0189194
RSF1 remodeling and spacing factor 1 -0.0188676