Cilostazol_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.173297
TMSB10 thymosin beta 10 0.124528
RPS3 ribosomal protein S3 0.114309
LAMB3 laminin, beta 3 0.0984293
BHLHE40 basic helix-loop-helix family, member e40 0.097699
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0886094
ACTG1 actin gamma 1 0.0843116
TMSB4X thymosin beta 4, X-linked 0.080099
RACK1 receptor for activated C kinase 1 0.0789158
LAMC2 laminin, gamma 2 0.0787013
KRT18 keratin 18, type I 0.0768518
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0692497
MYH9 myosin, heavy chain 9, non-muscle 0.0668725
RPL23 ribosomal protein L23 0.0640021
KRT7 keratin 7, type II 0.058522
HSPA8 heat shock 70kDa protein 8 0.0581679
CSTB cystatin B (stefin B) 0.0569044
RPS19 ribosomal protein S19 0.0563524
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0544029
CLDN4 claudin 4 0.0528379
RPS21 ribosomal protein S21 0.0522392
GPX4 glutathione peroxidase 4 0.0497194
CALR calreticulin 0.0478776
EEF2 eukaryotic translation elongation factor 2 0.0460582
SOX4 SRY (sex determining region Y)-box 4 0.0452682
RPL18 ribosomal protein L18 0.0419229
PRRC2C proline-rich coiled-coil 2C 0.0412344
NACA nascent polypeptide-associated complex alpha subunit 0.0406284
RPL37A ribosomal protein L37a 0.0401119
SET SET nuclear proto-oncogene 0.0391357
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0389225
G0S2 G0/G1 switch 2 0.03885
TM4SF1 transmembrane 4 L six family member 1 0.03758
RPS12 ribosomal protein S12 0.0372054
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.037078
PLEC plectin 0.0368927
MT2A metallothionein 2A 0.0357957
KRT8 keratin 8, type II 0.034588
LMNA lamin A/C 0.0343777
EIF4H eukaryotic translation initiation factor 4H 0.0342531
RPS10 ribosomal protein S10 0.0341014
RPL12 ribosomal protein L12 0.0338017
CCND1 cyclin D1 0.0337977
RPS17 ribosomal protein S17 0.0336752
CAPN2 calpain 2, (m/II) large subunit 0.03359
OAZ1 ornithine decarboxylase antizyme 1 0.0324428
BASP1 brain abundant, membrane attached signal protein 1 0.0312919
ANXA1 annexin A1 0.031265
RPL36 ribosomal protein L36 0.0306699
EPCAM epithelial cell adhesion molecule 0.0302217
RPL9 ribosomal protein L9 0.0297653
RPL30 ribosomal protein L30 0.0294505
DDIT4 DNA-damage-inducible transcript 4 0.0292634
CST3 cystatin C 0.0292401
PTPRF protein tyrosine phosphatase, receptor type, F 0.0292129
RPS29 ribosomal protein S29 0.0290557
TPI1 triosephosphate isomerase 1 0.0290227
LY6E lymphocyte antigen 6 complex, locus E 0.0290209
RPL26 ribosomal protein L26 0.0284887
ARRDC3 arrestin domain containing 3 0.0278255
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0277076
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0276464
MAP1B microtubule-associated protein 1B 0.0276284
TMED9 transmembrane emp24 protein transport domain containing 9 0.0274656
PTMA prothymosin, alpha 0.0271931
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.0270781
MDK midkine (neurite growth-promoting factor 2) 0.0269627
LPP LIM domain containing preferred translocation partner in lipoma 0.0268846
RPS18 ribosomal protein S18 0.0267578
GOLM1 golgi membrane protein 1 0.0266498
HLA-B major histocompatibility complex, class I, B 0.0266268
RBM25 RNA binding motif protein 25 0.026402
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0263599
RPL32 ribosomal protein L32 0.0257503
RPL34 ribosomal protein L34 0.025715
MKI67 marker of proliferation Ki-67 0.0255915
CTSB cathepsin B 0.0248719
FN1 fibronectin 1 0.0248054
FLNA filamin A, alpha 0.0244316
TUBB4B tubulin, beta 4B class IVb 0.0243332
AHDC1 AT hook, DNA binding motif, containing 1 0.0242278
AHNAK2 AHNAK nucleoprotein 2 0.0240538
CLIC1 chloride intracellular channel 1 0.0239685
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.0238393
ISG15 ISG15 ubiquitin-like modifier 0.0237057
MSN moesin 0.0236356
PLAU plasminogen activator, urokinase 0.0236155
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0234554
SFTPA2 surfactant protein A2 0.0233604
IFI27 interferon, alpha-inducible protein 27 0.0232908
CTTN cortactin 0.0228824
COL6A1 collagen, type VI, alpha 1 0.0228732
RPL8 ribosomal protein L8 0.0226514
TPM3 tropomyosin 3 0.0223024
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.0222946
RPLP2 ribosomal protein, large, P2 0.0220548
TMEM14C transmembrane protein 14C 0.0216603
HDGF hepatoma-derived growth factor 0.0214218
LDHA lactate dehydrogenase A 0.0212915
TMED2 transmembrane emp24 domain trafficking protein 2 0.0211596

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.213074
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.190773
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.172589
TSC22D2 TSC22 domain family, member 2 -0.160974
NDRG1 N-myc downstream regulated 1 -0.120989
FNDC3B fibronectin type III domain containing 3B -0.115247
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0857788
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.085244
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0752588
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0730357
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0674235
ASPH aspartate beta-hydroxylase -0.0668429
CANX calnexin -0.0650284
KMT2E lysine (K)-specific methyltransferase 2E -0.0638871
POTEF POTE ankyrin domain family, member F -0.061037
ZFAND3 zinc finger, AN1-type domain 3 -0.0609137
NPEPPS aminopeptidase puromycin sensitive -0.0606179
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0575206
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0548861
PTK2 protein tyrosine kinase 2 -0.0544301
USP3 ubiquitin specific peptidase 3 -0.0541275
RYBP RING1 and YY1 binding protein -0.0541211
FAM13A family with sequence similarity 13, member A -0.0519221
SPAG9 sperm associated antigen 9 -0.05073
AHNAK AHNAK nucleoprotein -0.0503957
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0501187
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0497516
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0495973
RNF145 ring finger protein 145 -0.0491758
RPL35A ribosomal protein L35a -0.0483764
CCNL1 cyclin L1 -0.0473369
RAB1A RAB1A, member RAS oncogene family -0.0470113
MARCHF6 membrane associated ring-CH-type finger 6 -0.0469243
ZNF292 zinc finger protein 292 -0.0449736
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0448126
PCBP2 poly(rC) binding protein 2 -0.0430825
SETD5 SET domain containing 5 -0.0424655
RBM39 RNA binding motif protein 39 -0.0421327
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0420618
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0412552
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0406856
PDIA3 protein disulfide isomerase family A, member 3 -0.0406752
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0403895
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0392042
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0389578
SSBP2 single-stranded DNA binding protein 2 -0.038687
RHEB Ras homolog enriched in brain -0.0380013
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0379573
RPS25 ribosomal protein S25 -0.0379413
DSCAM Down syndrome cell adhesion molecule -0.0368704
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0367889
VDAC1 voltage-dependent anion channel 1 -0.0366727
TXNRD1 thioredoxin reductase 1 -0.0363329
IFRD1 interferon-related developmental regulator 1 -0.0361537
ELL2 elongation factor, RNA polymerase II, 2 -0.0360239
SLMAP sarcolemma associated protein -0.0359895
ERBIN erbb2 interacting protein -0.0355767
RIOK3 RIO kinase 3 -0.0352177
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0347419
RLF rearranged L-myc fusion -0.0333997
WASF2 WAS protein family, member 2 -0.0333487
FBXO11 F-box protein 11 -0.0333062
KDM5B lysine (K)-specific demethylase 5B -0.0331202
ZNF207 zinc finger protein 207 -0.0331061
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0328274
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0328239
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.032227
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.031992
CD109 CD109 molecule -0.031879
ATP11B ATPase, class VI, type 11B -0.0314496
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0313844
ANXA2 annexin A2 -0.0313329
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0311977
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0310364
MEF2A myocyte enhancer factor 2A -0.0309525
QKI QKI, KH domain containing, RNA binding -0.030722
RTN4 reticulon 4 -0.0304291
GARS1 glycyl-tRNA synthetase 1 -0.0301082
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.029735
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0296278
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0295105
TMEM123 transmembrane protein 123 -0.02948
S100A10 S100 calcium binding protein A10 -0.0294162
TOP1 topoisomerase (DNA) I -0.0290767
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.029024
PGK1 phosphoglycerate kinase 1 -0.0290155
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0289432
MCL1 myeloid cell leukemia 1 -0.028627
TRA2A transformer 2 alpha homolog (Drosophila) -0.0285189
JMJD1C jumonji domain containing 1C -0.0283918
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0283209
RHOA ras homolog family member A -0.0283104
RTN3 reticulon 3 -0.0282778
AFF4 AF4/FMR2 family, member 4 -0.0280526
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0280518
CD2AP CD2-associated protein -0.0279074
FHIT fragile histidine triad -0.0278737
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0278063
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0276637
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0274378