Cilostazol_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPAG9 sperm associated antigen 9 0.116544
AKAP12 A kinase (PRKA) anchor protein 12 0.112514
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.110729
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0882954
WAC WW domain containing adaptor with coiled-coil 0.0853363
NAMPT nicotinamide phosphoribosyltransferase 0.0847349
STC1 stanniocalcin 1 0.0835402
TM4SF1 transmembrane 4 L six family member 1 0.0737772
PGK1 phosphoglycerate kinase 1 0.0732312
P3H2 prolyl 3-hydroxylase 2 0.0708002
PDE4D phosphodiesterase 4D, cAMP-specific 0.0703793
MAML2 mastermind-like 2 (Drosophila) 0.0661755
NBAS neuroblastoma amplified sequence 0.0655824
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0637204
CUL3 cullin 3 0.0634263
CD44 CD44 molecule (Indian blood group) 0.0634075
EGFR epidermal growth factor receptor 0.0614092
JMJD1C jumonji domain containing 1C 0.0613916
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0610308
DLG1 discs, large homolog 1 (Drosophila) 0.059008
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0584443
IER3 immediate early response 3 0.0583008
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0582532
CXCL8 chemokine (C-X-C motif) ligand 8 0.0555561
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0555099
BHLHE40 basic helix-loop-helix family, member e40 0.0550282
KDM5B lysine (K)-specific demethylase 5B 0.0543882
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0542362
LRP12 low density lipoprotein receptor-related protein 12 0.0538141
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0537459
LAMA4 laminin, alpha 4 0.052745
MYO1E myosin IE 0.0504168
NPEPPS aminopeptidase puromycin sensitive 0.0502811
NDRG1 N-myc downstream regulated 1 0.0497409
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0491444
IGF2 insulin-like growth factor 2 0.0484355
KDM3A lysine (K)-specific demethylase 3A 0.0483995
NKD1 naked cuticle homolog 1 (Drosophila) 0.0483432
NUMB numb homolog (Drosophila) 0.048154
MMP1 matrix metallopeptidase 1 0.047309
ACTN4 actinin, alpha 4 0.0469609
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0468158
LIMS1 LIM and senescent cell antigen-like domains 1 0.0468129
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0458699
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0456091
EZR ezrin 0.0453736
BRWD3 bromodomain and WD repeat domain containing 3 0.0452984
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0448503
NAP1L4 nucleosome assembly protein 1-like 4 0.0447063
SEPTIN7 septin 7 0.0446057
RAD23B RAD23 homolog B (S. cerevisiae) 0.0445309
USP34 ubiquitin specific peptidase 34 0.0444465
S100A10 S100 calcium binding protein A10 0.0436385
RTN4 reticulon 4 0.0436196
ZFAND3 zinc finger, AN1-type domain 3 0.0434827
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0431215
COL1A1 collagen, type I, alpha 1 0.0430114
DDIT4 DNA-damage-inducible transcript 4 0.0421563
MSN moesin 0.0416867
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0407208
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0406848
HMGA2 high mobility group AT-hook 2 0.040598
LDHA lactate dehydrogenase A 0.0405903
AGO2 argonaute RISC catalytic component 2 0.0403554
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.039585
FAF1 Fas (TNFRSF6) associated factor 1 0.039488
TNRC6B trinucleotide repeat containing 6B 0.039462
TENT5A terminal nucleotidyltransferase 5A 0.0394468
NT5C2 5'-nucleotidase, cytosolic II 0.039058
RPL11 ribosomal protein L11 0.0389833
AHCYL2 adenosylhomocysteinase-like 2 0.0388019
CDH13 cadherin 13 0.0383833
CLINT1 clathrin interactor 1 0.0383279
ANKRD12 ankyrin repeat domain 12 0.0381463
WDR45B WD repeat domain 45B 0.0381267
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0377033
MON2 MON2 homolog (S. cerevisiae) 0.0376262
HOOK2 hook microtubule-tethering protein 2 0.0375983
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0369649
TRA2A transformer 2 alpha homolog (Drosophila) 0.0369287
MBNL1 muscleblind-like splicing regulator 1 0.0368364
PKM pyruvate kinase, muscle 0.0367319
VCL vinculin 0.0365826
YTHDC1 YTH domain containing 1 0.0361729
ITCH itchy E3 ubiquitin protein ligase 0.0349009
KDM6A lysine (K)-specific demethylase 6A 0.0345862
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0344728
ITSN1 intersectin 1 (SH3 domain protein) 0.0340975
EIF1 eukaryotic translation initiation factor 1 0.0330605
ZMYM2 zinc finger, MYM-type 2 0.0327607
ANKRD10 ankyrin repeat domain 10 0.0323709
CALU calumenin 0.0322609
ZNF292 zinc finger protein 292 0.0319287
LAMB3 laminin, beta 3 0.0317405
UBA6 ubiquitin-like modifier activating enzyme 6 0.0314047
ITPRID2 ITPR interacting domain containing 2 0.0312377
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0311726
JARID2 jumonji, AT rich interactive domain 2 0.0310629
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0301909
GSK3B glycogen synthase kinase 3 beta 0.0297891

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.138942
TRIO trio Rho guanine nucleotide exchange factor -0.132813
VMP1 vacuole membrane protein 1 -0.131534
ZBTB20 zinc finger and BTB domain containing 20 -0.121435
KMT2C lysine (K)-specific methyltransferase 2C -0.107569
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0982254
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0957385
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0916098
NCOR1 nuclear receptor corepressor 1 -0.0913936
FLNB filamin B, beta -0.091192
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0894002
PDE10A phosphodiesterase 10A -0.083975
ZNF609 zinc finger protein 609 -0.0827105
FTH1 ferritin, heavy polypeptide 1 -0.0792883
MYOF myoferlin -0.0788761
EEF2 eukaryotic translation elongation factor 2 -0.0772752
MED13L mediator complex subunit 13-like -0.0761712
PRRC2B proline-rich coiled-coil 2B -0.0761034
EFNA5 ephrin-A5 -0.0758592
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0756044
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0740201
AHNAK AHNAK nucleoprotein -0.0727193
GMDS GDP-mannose 4,6-dehydratase -0.0695994
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0682728
GOLGB1 golgin B1 -0.0679274
TTC3 tetratricopeptide repeat domain 3 -0.0677789
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0663856
MATR3 matrin 3 -0.0661501
PRRC2C proline-rich coiled-coil 2C -0.0653693
LIMCH1 LIM and calponin homology domains 1 -0.065066
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0643404
ANKRD17 ankyrin repeat domain 17 -0.0636684
RPL7 ribosomal protein L7 -0.063502
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0630698
BBX bobby sox homolog (Drosophila) -0.0616699
PRKCA protein kinase C, alpha -0.0616434
FNDC3B fibronectin type III domain containing 3B -0.0614027
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0611003
TXNRD1 thioredoxin reductase 1 -0.0604592
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.059503
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0579148
ANXA2 annexin A2 -0.0558967
ADNP activity-dependent neuroprotector homeobox -0.0540493
NF1 neurofibromin 1 -0.0534085
RBM39 RNA binding motif protein 39 -0.0524912
ASPH aspartate beta-hydroxylase -0.0518716
ACTG1 actin gamma 1 -0.0518623
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0504418
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0501656
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0492447
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0491072
GPC6 glypican 6 -0.0482197
RAB6A RAB6A, member RAS oncogene family -0.0482116
ESYT2 extended synaptotagmin-like protein 2 -0.0479661
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0474912
RPL37A ribosomal protein L37a -0.0460048
RORA RAR-related orphan receptor A -0.0459919
LOC112694756 uncharaterized LOC112694756 -0.0427243
MEF2A myocyte enhancer factor 2A -0.0425109
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0415809
NCOA3 nuclear receptor coactivator 3 -0.0411443
PCBP2 poly(rC) binding protein 2 -0.0400483
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0395093
EGR1 early growth response 1 -0.0386583
POTEF POTE ankyrin domain family, member F -0.0382613
TBC1D5 TBC1 domain family, member 5 -0.0382573
FAM13A family with sequence similarity 13, member A -0.038248
HELZ helicase with zinc finger -0.0369267
AKAP9 A kinase (PRKA) anchor protein 9 -0.03677
RSF1 remodeling and spacing factor 1 -0.0364657
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0360698
CSNK1A1 casein kinase 1, alpha 1 -0.0356381
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0349042
CANX calnexin -0.0342754
RLF rearranged L-myc fusion -0.0336034
ETNK1 ethanolamine kinase 1 -0.0335033
NPAS2 neuronal PAS domain protein 2 -0.0333418
EHBP1 EH domain binding protein 1 -0.0328897
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0321863
PTK2 protein tyrosine kinase 2 -0.0314248
RPS6 ribosomal protein S6 -0.0313041
ENO1 enolase 1, (alpha) -0.0307031
PTGES2 prostaglandin E synthase 2 -0.0292511
TMSB10 thymosin beta 10 -0.0287048
FN1 fibronectin 1 -0.0286625
NALF1 NALCN channel auxiliary factor 1 -0.0281759
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0281267
MAP4 microtubule-associated protein 4 -0.0275084
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0262543
BACE2 beta-site APP-cleaving enzyme 2 -0.026048
PRELID2 PRELI domain containing 2 -0.0253597
AFDN afadin, adherens junction formation factor -0.0252878
CHD9 chromodomain helicase DNA binding protein 9 -0.0249787
RASA3 RAS p21 protein activator 3 -0.0249071
RPS8 ribosomal protein S8 -0.024746
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0242653
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0235702
FAT1 FAT atypical cadherin 1 -0.0231593
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0229707
DSCAM Down syndrome cell adhesion molecule -0.022843