Cilostazol_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.101834
COL5A2 collagen, type V, alpha 2 0.0904942
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0833957
MKI67 marker of proliferation Ki-67 0.0831742
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0822563
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0772122
RPS6 ribosomal protein S6 0.064894
RPS12 ribosomal protein S12 0.0641919
COL3A1 collagen, type III, alpha 1 0.0630309
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0616359
ACTG1 actin gamma 1 0.0580957
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0578858
CADM2 cell adhesion molecule 2 0.0512911
NTM neurotrimin 0.0511096
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0510637
VIM vimentin 0.050338
PTMA prothymosin, alpha 0.0428451
PCDH9 protocadherin 9 0.0427548
RPLP1 ribosomal protein, large, P1 0.0406454
RPS3 ribosomal protein S3 0.039119
RPS8 ribosomal protein S8 0.0389084
RPS21 ribosomal protein S21 0.0387808
TMSB10 thymosin beta 10 0.0384239
RPS19 ribosomal protein S19 0.0374645
RPL23 ribosomal protein L23 0.0358049
MDK midkine (neurite growth-promoting factor 2) 0.0355233
CALR calreticulin 0.0351521
RPS2 ribosomal protein S2 0.034427
NACA nascent polypeptide-associated complex alpha subunit 0.0324119
EEF2 eukaryotic translation elongation factor 2 0.0314246
TMSB4X thymosin beta 4, X-linked 0.0310635
RPL26 ribosomal protein L26 0.0309087
RPL36 ribosomal protein L36 0.0307069
SSR1 signal sequence receptor, alpha 0.0303892
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0297071
RACK1 receptor for activated C kinase 1 0.0285914
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.028583
OAZ1 ornithine decarboxylase antizyme 1 0.0284331
EEF1G eukaryotic translation elongation factor 1 gamma 0.0282444
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0279267
ADGRV1 adhesion G protein-coupled receptor V1 0.0272192
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.027026
RPL12 ribosomal protein L12 0.026983
RPLP0 ribosomal protein, large, P0 0.0268795
HMGB2 high mobility group box 2 0.0267349
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0265403
GSE1 Gse1 coiled-coil protein 0.02625
ANXA1 annexin A1 0.025953
LDHA lactate dehydrogenase A 0.0259387
FOXG1 forkhead box G1 0.0258096
RPS16 ribosomal protein S16 0.0256587
ENO1 enolase 1, (alpha) 0.0256447
RPL5 ribosomal protein L5 0.0255689
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0252779
RPL18 ribosomal protein L18 0.0251996
GREB1L growth regulation by estrogen in breast cancer-like 0.025004
KCTD16 potassium channel tetramerization domain containing 16 0.0248706
VEGFA vascular endothelial growth factor A 0.0246885
SMC1A structural maintenance of chromosomes 1A 0.0246754
PCLO piccolo presynaptic cytomatrix protein 0.0245133
EIF4H eukaryotic translation initiation factor 4H 0.0243179
RPS4X ribosomal protein S4, X-linked 0.0241905
CSDE1 cold shock domain containing E1, RNA-binding 0.024185
RPS27A ribosomal protein S27a 0.0240481
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0238238
FST follistatin 0.0237621
RPL13A ribosomal protein L13a 0.0235996
DOCK5 dedicator of cytokinesis 5 0.0232134
RPLP2 ribosomal protein, large, P2 0.0231585
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0230518
PRELID2 PRELI domain containing 2 0.0230426
RPL11 ribosomal protein L11 0.0229878
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0228976
RPL7 ribosomal protein L7 0.0228882
ARHGAP15 Rho GTPase activating protein 15 0.0228348
CENPF centromere protein F, 350/400kDa 0.0228255
MYH9 myosin, heavy chain 9, non-muscle 0.0227938
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0219997
CKAP5 cytoskeleton associated protein 5 0.0218993
RPL37A ribosomal protein L37a 0.0216728
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0212766
FUS FUS RNA binding protein 0.0212036
PRRC2C proline-rich coiled-coil 2C 0.0210498
NRDC nardilysin convertase 0.0210171
TPM3 tropomyosin 3 0.0205585
RPS29 ribosomal protein S29 0.0204246
RPL7A ribosomal protein L7a 0.0203781
FOXP2 forkhead box P2 0.0202605
HMCN1 hemicentin 1 0.0202326
COL1A2 collagen, type I, alpha 2 0.0201701
RPL37 ribosomal protein L37 0.0200083
ITGAV integrin, alpha V 0.0197281
RPS13 ribosomal protein S13 0.0196775
PCDH11Y protocadherin 11 Y-linked 0.0196291
PDCD5 programmed cell death 5 0.0195585
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.0193052
SFRP4 secreted frizzled-related protein 4 0.01921
SERF2 small EDRK-rich factor 2 0.0192089
AKAP12 A kinase (PRKA) anchor protein 12 0.0191457
RPS18 ribosomal protein S18 0.0191124

decreased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 -0.117284
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116033
ZFAND3 zinc finger, AN1-type domain 3 -0.102672
TRIO trio Rho guanine nucleotide exchange factor -0.0927035
PGAP1 post-GPI attachment to proteins 1 -0.0884803
FNDC3B fibronectin type III domain containing 3B -0.0854898
FBXO11 F-box protein 11 -0.0843679
ZNF292 zinc finger protein 292 -0.0778957
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0762072
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0744851
SRP54 signal recognition particle 54kDa -0.0682562
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0665839
STRN3 striatin, calmodulin binding protein 3 -0.066571
MRPS30 mitochondrial ribosomal protein S30 -0.0649716
PEG10 paternally expressed 10 -0.0637483
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0592583
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0563899
PHIP pleckstrin homology domain interacting protein -0.055963
KMT2C lysine (K)-specific methyltransferase 2C -0.0545837
SPAG9 sperm associated antigen 9 -0.0544032
KMT2E lysine (K)-specific methyltransferase 2E -0.0537004
CDC73 cell division cycle 73 -0.052918
NOP58 NOP58 ribonucleoprotein -0.0527643
ADGRL3 adhesion G protein-coupled receptor L3 -0.0507456
ARID4B AT rich interactive domain 4B (RBP1-like) -0.049527
MED13L mediator complex subunit 13-like -0.048706
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0477005
IGF1R insulin-like growth factor 1 receptor -0.0474602
BIRC6 baculoviral IAP repeat containing 6 -0.0468552
PLPP1 phospholipid phosphatase 1 -0.0457336
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0450881
RTN4 reticulon 4 -0.0448509
ZEB2 zinc finger E-box binding homeobox 2 -0.0448103
NCOR1 nuclear receptor corepressor 1 -0.0435232
JMJD1C jumonji domain containing 1C -0.0431486
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0430775
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0428809
HDAC9 histone deacetylase 9 -0.0425482
SEC31A SEC31 homolog A (S. cerevisiae) -0.0423546
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0422988
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0414773
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0413495
MAP4 microtubule-associated protein 4 -0.0388894
TRA2A transformer 2 alpha homolog (Drosophila) -0.0385257
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0384534
USP3 ubiquitin specific peptidase 3 -0.0382453
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0377401
ENAH enabled homolog (Drosophila) -0.0374736
RASAL2 RAS protein activator like 2 -0.0366304
ANKRD33B ankyrin repeat domain 33B -0.0365251
EVI5 ecotropic viral integration site 5 -0.0360314
ZC3H15 zinc finger CCCH-type containing 15 -0.0355311
ZNF217 zinc finger protein 217 -0.0354138
LYST lysosomal trafficking regulator -0.0353282
WDR43 WD repeat domain 43 -0.0349058
ZNF207 zinc finger protein 207 -0.0337341
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0336501
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0336363
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0333639
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0331827
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0331493
SYT1 synaptotagmin I -0.0330009
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0328774
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0327845
PTK2 protein tyrosine kinase 2 -0.032703
ARL13B ADP-ribosylation factor-like 13B -0.0316876
EMP1 epithelial membrane protein 1 -0.031425
BRWD1 bromodomain and WD repeat domain containing 1 -0.031359
NRG1 neuregulin 1 -0.0311893
ZFPM2 zinc finger protein, FOG family member 2 -0.0310438
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.030992
CHD7 chromodomain helicase DNA binding protein 7 -0.030661
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0306104
NEBL nebulette -0.0304534
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0298471
GRB2 growth factor receptor-bound protein 2 -0.0295944
MARCHF6 membrane associated ring-CH-type finger 6 -0.0295336
KIF1B kinesin family member 1B -0.0295218
SETD5 SET domain containing 5 -0.0294627
PRR16 proline rich 16 -0.0294574
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0294416
USP15 ubiquitin specific peptidase 15 -0.0289278
TRPS1 trichorhinophalangeal syndrome I -0.0289093
MTF2 metal response element binding transcription factor 2 -0.0287185
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0285144
RLF rearranged L-myc fusion -0.0283567
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0282493
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0281991
FAM171B family with sequence similarity 171, member B -0.0281104
RNF13 ring finger protein 13 -0.027975
ANK2 ankyrin 2, neuronal -0.0278039
LATS2 large tumor suppressor kinase 2 -0.0278011
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0276628
COG5 component of oligomeric golgi complex 5 -0.0275566
CPA6 carboxypeptidase A6 -0.0273935
TAOK1 TAO kinase 1 -0.0273854
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0270762
FMNL2 formin-like 2 -0.02685
GOLGA4 golgin A4 -0.0267471
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0264221