Cilostazol_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.124632
RPS3 ribosomal protein S3 0.103522
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0897725
EEF2 eukaryotic translation elongation factor 2 0.089504
RPL37A ribosomal protein L37a 0.0718196
RPS8 ribosomal protein S8 0.0672768
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0627531
RPS6 ribosomal protein S6 0.0568938
RPS12 ribosomal protein S12 0.0546566
RPS19 ribosomal protein S19 0.0492672
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0478677
PRELID2 PRELI domain containing 2 0.0465135
RPL13A ribosomal protein L13a 0.0451753
FLNB filamin B, beta 0.0451707
SET SET nuclear proto-oncogene 0.0449622
RPL3 ribosomal protein L3 0.0445423
RPL36 ribosomal protein L36 0.0435396
VEGFA vascular endothelial growth factor A 0.0431468
RPL9 ribosomal protein L9 0.0429529
RPL26 ribosomal protein L26 0.0424152
MKI67 marker of proliferation Ki-67 0.0423174
ENO2 enolase 2 (gamma, neuronal) 0.0419114
GOLGA4 golgin A4 0.0417285
RPL23 ribosomal protein L23 0.0416412
PFN1 profilin 1 0.0397766
SRRM2 serine/arginine repetitive matrix 2 0.0394637
CSF1 colony stimulating factor 1 (macrophage) 0.0378322
MT2A metallothionein 2A 0.0370741
NACA nascent polypeptide-associated complex alpha subunit 0.0369327
ACTG1 actin gamma 1 0.0366746
RPS23 ribosomal protein S23 0.0364162
RPS17 ribosomal protein S17 0.0357187
ENO1 enolase 1, (alpha) 0.0352201
RPL11 ribosomal protein L11 0.0309186
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0308184
EIF4B eukaryotic translation initiation factor 4B 0.0304778
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.029846
LDHA lactate dehydrogenase A 0.0295612
FAT1 FAT atypical cadherin 1 0.0293924
RPL7A ribosomal protein L7a 0.0293471
RPS21 ribosomal protein S21 0.0290896
RACK1 receptor for activated C kinase 1 0.0289399
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0286149
RPS2 ribosomal protein S2 0.0284198
PRDX2 peroxiredoxin 2 0.0279745
HDGF hepatoma-derived growth factor 0.02792
RPL31 ribosomal protein L31 0.027814
AMOTL2 angiomotin like 2 0.0270186
RPL18 ribosomal protein L18 0.0262062
PNN pinin, desmosome associated protein 0.0253426
HILPDA hypoxia inducible lipid droplet-associated 0.0250939
SQSTM1 sequestosome 1 0.0248228
CENPF centromere protein F, 350/400kDa 0.0245689
RPS10 ribosomal protein S10 0.0242821
GSE1 Gse1 coiled-coil protein 0.0242561
TBC1D22A TBC1 domain family, member 22A 0.0237503
RPS27 ribosomal protein S27 0.0237228
PLXNA1 plexin A1 0.023566
RPLP2 ribosomal protein, large, P2 0.0234489
RPL12 ribosomal protein L12 0.0233487
BRD2 bromodomain containing 2 0.0232019
ATN1 atrophin 1 0.0230644
EBNA1BP2 EBNA1 binding protein 2 0.0226198
RPS18 ribosomal protein S18 0.0221261
RPS11 ribosomal protein S11 0.0221056
RPS4X ribosomal protein S4, X-linked 0.0215351
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.0215269
UNC13A unc-13 homolog A (C. elegans) 0.0215011
CD47 CD47 molecule 0.0213824
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0212753
FAM13A family with sequence similarity 13, member A 0.0211612
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0211409
HSPA8 heat shock 70kDa protein 8 0.0210737
CABIN1 calcineurin binding protein 1 0.020954
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0209018
PRRC2C proline-rich coiled-coil 2C 0.0208608
RPL27 ribosomal protein L27 0.0208469
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0207471
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0206148
YEATS2 YEATS domain containing 2 0.0204873
TMEM14B transmembrane protein 14B 0.020468
RPL21 ribosomal protein L21 0.0203881
TMEM65 transmembrane protein 65 0.0199563
TPI1 triosephosphate isomerase 1 0.0198816
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.019675
MSN moesin 0.019461
RPL30 ribosomal protein L30 0.0192622
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0190909
FN1 fibronectin 1 0.0189803
FTL ferritin, light polypeptide 0.0189431
EIF4H eukaryotic translation initiation factor 4H 0.0187794
UBAP2L ubiquitin associated protein 2-like 0.0185902
TMF1 TATA element modulatory factor 1 0.0184249
ANKRD36B ankyrin repeat domain 36B 0.0183538
RPL35 ribosomal protein L35 0.0182335
ANKRD12 ankyrin repeat domain 12 0.0181108
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0178535
DAPK3 death-associated protein kinase 3 0.0178234
B2M beta-2-microglobulin 0.0177301
LOXL3 lysyl oxidase-like 3 0.0175932

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.236148
VCL vinculin -0.122367
AHNAK AHNAK nucleoprotein -0.105465
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.103721
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0869988
SSBP2 single-stranded DNA binding protein 2 -0.0831196
ZFAND3 zinc finger, AN1-type domain 3 -0.0720153
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0719276
PDE4D phosphodiesterase 4D, cAMP-specific -0.0619497
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0609979
FOXP1 forkhead box P1 -0.0608886
RTN4 reticulon 4 -0.0516177
JMJD1C jumonji domain containing 1C -0.0499914
PDE4B phosphodiesterase 4B, cAMP-specific -0.0482122
ZEB1 zinc finger E-box binding homeobox 1 -0.0481218
LOC112694756 uncharaterized LOC112694756 -0.0464307
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0462992
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0460035
NBEA neurobeachin -0.0450473
GARS1 glycyl-tRNA synthetase 1 -0.0429606
FBXO11 F-box protein 11 -0.0427267
CDC73 cell division cycle 73 -0.0405994
RHEB Ras homolog enriched in brain -0.0393955
DLG1 discs, large homolog 1 (Drosophila) -0.0388169
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0386956
KDM3A lysine (K)-specific demethylase 3A -0.0386425
TCF12 transcription factor 12 -0.0374105
ADAM10 ADAM metallopeptidase domain 10 -0.0370042
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0367793
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0364913
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0361026
BMP10 bone morphogenetic protein 10 -0.0356077
PARD3 par-3 family cell polarity regulator -0.0354607
RAB1A RAB1A, member RAS oncogene family -0.0350695
CAMKMT calmodulin-lysine N-methyltransferase -0.0344844
HDAC9 histone deacetylase 9 -0.0340564
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0339987
WAC WW domain containing adaptor with coiled-coil -0.0334521
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0333987
NFIA nuclear factor I/A -0.0333192
QKI QKI, KH domain containing, RNA binding -0.032915
EML4 echinoderm microtubule associated protein like 4 -0.0327767
RBM39 RNA binding motif protein 39 -0.032667
RHOA ras homolog family member A -0.0326034
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0324627
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0324081
RLF rearranged L-myc fusion -0.032123
TPT1 tumor protein, translationally-controlled 1 -0.0319688
ARL4C ADP-ribosylation factor-like 4C -0.0315615
USP3 ubiquitin specific peptidase 3 -0.031222
PUM2 pumilio RNA-binding family member 2 -0.0310667
IARS1 isoleucyl-tRNA synthetase 1 -0.0310635
ZNF207 zinc finger protein 207 -0.0305313
TRA2A transformer 2 alpha homolog (Drosophila) -0.0302319
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.030196
MARCHF6 membrane associated ring-CH-type finger 6 -0.0300236
ZNF292 zinc finger protein 292 -0.0299464
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0298219
KMT2E lysine (K)-specific methyltransferase 2E -0.0298019
ZBTB20 zinc finger and BTB domain containing 20 -0.0289968
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0288989
ANKRD11 ankyrin repeat domain 11 -0.0288562
MED13 mediator complex subunit 13 -0.0287456
TASOR2 transcription activation suppressor family member 2 -0.0281248
EXT1 exostosin glycosyltransferase 1 -0.0278748
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0274461
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0273932
SENP6 SUMO1/sentrin specific peptidase 6 -0.0273322
EXOC6B exocyst complex component 6B -0.0271555
PDS5A PDS5 cohesin associated factor A -0.026947
ECT2 epithelial cell transforming 2 -0.0268434
BIRC6 baculoviral IAP repeat containing 6 -0.0264573
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0263615
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0262844
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0262139
ZNF644 zinc finger protein 644 -0.0260226
RTN3 reticulon 3 -0.0259158
TXNRD1 thioredoxin reductase 1 -0.0258974
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.02533
NIPBL Nipped-B homolog (Drosophila) -0.0252491
CRY1 cryptochrome circadian clock 1 -0.025163
RPS24 ribosomal protein S24 -0.0250286
SMNDC1 survival motor neuron domain containing 1 -0.0249663
TJP1 tight junction protein 1 -0.0248521
DPYD dihydropyrimidine dehydrogenase -0.0247944
NT5C2 5'-nucleotidase, cytosolic II -0.0245543
TNPO1 transportin 1 -0.024363
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0243248
MEF2A myocyte enhancer factor 2A -0.0242289
USP34 ubiquitin specific peptidase 34 -0.0240134
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0239864
PTPRG protein tyrosine phosphatase, receptor type, G -0.0239767
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0239441
PUM1 pumilio RNA-binding family member 1 -0.0239329
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0236516
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0235474
GPHN gephyrin -0.0234902
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0234641
SLC38A2 solute carrier family 38, member 2 -0.0230891
SPIDR scaffolding protein involved in DNA repair -0.023082