Cilostazol_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.179929
FN1 fibronectin 1 0.149025
MYH9 myosin, heavy chain 9, non-muscle 0.114063
EEF2 eukaryotic translation elongation factor 2 0.0832359
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.077736
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0664644
MSN moesin 0.0664359
MKI67 marker of proliferation Ki-67 0.0652025
FRMD4A FERM domain containing 4A 0.0649988
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0621961
COL6A3 collagen, type VI, alpha 3 0.0586558
NAMPT nicotinamide phosphoribosyltransferase 0.0566508
NAV2 neuron navigator 2 0.0547421
FNDC3B fibronectin type III domain containing 3B 0.0532105
CADM1 cell adhesion molecule 1 0.0505737
CENPF centromere protein F, 350/400kDa 0.0391251
UGCG UDP-glucose ceramide glucosyltransferase 0.0390963
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0390788
FLNA filamin A, alpha 0.0386652
FTH1 ferritin, heavy polypeptide 1 0.0384412
ICAM1 intercellular adhesion molecule 1 0.037344
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0357577
ELL2 elongation factor, RNA polymerase II, 2 0.0357438
TNIP1 TNFAIP3 interacting protein 1 0.0352977
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0347524
OPTN optineurin 0.033649
USP9X ubiquitin specific peptidase 9, X-linked 0.0335792
RPS3 ribosomal protein S3 0.0328841
CCNL1 cyclin L1 0.0322334
ATP13A3 ATPase type 13A3 0.0300471
ZMIZ1 zinc finger, MIZ-type containing 1 0.0298144
VCAN versican 0.0296057
C3 complement component 3 0.0291666
MYOF myoferlin 0.0272697
ARRDC3 arrestin domain containing 3 0.0269375
DST dystonin 0.0268016
RPS18 ribosomal protein S18 0.0262901
RTN4 reticulon 4 0.026162
SFTPA2 surfactant protein A2 0.0255478
ANLN anillin, actin binding protein 0.0251351
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0249829
SRRM2 serine/arginine repetitive matrix 2 0.0248314
SMAD3 SMAD family member 3 0.0247522
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0246402
CKAP5 cytoskeleton associated protein 5 0.0244606
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0240352
LOXL2 lysyl oxidase-like 2 0.0237613
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0227467
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0218742
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0218229
AHDC1 AT hook, DNA binding motif, containing 1 0.0217067
CD44 CD44 molecule (Indian blood group) 0.0210421
CEP250 centrosomal protein 250kDa 0.0210384
DENND5A DENN/MADD domain containing 5A 0.0209676
YBX1 Y box binding protein 1 0.0201981
CALD1 caldesmon 1 0.0201326
ZFP36L1 ZFP36 ring finger protein-like 1 0.020101
ZNF292 zinc finger protein 292 0.019897
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0198872
FLNB filamin B, beta 0.0197937
HSPA8 heat shock 70kDa protein 8 0.0195259
MATR3 matrin 3 0.0193849
RPL3 ribosomal protein L3 0.0189484
COL8A1 collagen, type VIII, alpha 1 0.0188861
TNS3 tensin 3 0.0186901
TPX2 TPX2, microtubule-associated 0.0185477
RPS12 ribosomal protein S12 0.0183135
UBA6 ubiquitin-like modifier activating enzyme 6 0.0181753
SET SET nuclear proto-oncogene 0.0178179
KIF4A kinesin family member 4A 0.0177895
AFDN afadin, adherens junction formation factor 0.0177349
BHLHE40 basic helix-loop-helix family, member e40 0.0176329
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0172934
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0172079
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0172018
STC2 stanniocalcin 2 0.0171996
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0171185
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0170771
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.017049
PTPRF protein tyrosine phosphatase, receptor type, F 0.0170112
DIAPH3 diaphanous-related formin 3 0.0169589
CST3 cystatin C 0.0167995
BCAR3 breast cancer anti-estrogen resistance 3 0.0167143
RAI1 retinoic acid induced 1 0.0166992
MLPH melanophilin 0.0166233
RPL37A ribosomal protein L37a 0.0165861
RNF145 ring finger protein 145 0.0165485
WTAP Wilms tumor 1 associated protein 0.0165066
BCLAF1 BCL2-associated transcription factor 1 0.0163244
CSDE1 cold shock domain containing E1, RNA-binding 0.0163178
MXI1 MAX interactor 1, dimerization protein 0.0162918
TENM2 teneurin transmembrane protein 2 0.0161134
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0160482
KDM6A lysine (K)-specific demethylase 6A 0.0160256
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.015994
TPM3 tropomyosin 3 0.0156741
THBS1 thrombospondin 1 0.0155059
LDHA lactate dehydrogenase A 0.015407
QKI QKI, KH domain containing, RNA binding 0.0151582
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0150742

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.14729
TPT1 tumor protein, translationally-controlled 1 -0.0874127
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0709527
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0681513
GLIS3 GLIS family zinc finger 3 -0.0663571
IER3 immediate early response 3 -0.0637497
HMGA2 high mobility group AT-hook 2 -0.0614022
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0607952
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0591848
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.051637
RPS24 ribosomal protein S24 -0.0509463
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0476714
MARCKS myristoylated alanine-rich protein kinase C substrate -0.04462
AKAP12 A kinase (PRKA) anchor protein 12 -0.0433737
RPL35A ribosomal protein L35a -0.042013
VCL vinculin -0.0419534
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0390579
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0381116
BTG1 B-cell translocation gene 1, anti-proliferative -0.037573
AHNAK AHNAK nucleoprotein -0.037068
NAP1L1 nucleosome assembly protein 1-like 1 -0.0369147
HLA-E major histocompatibility complex, class I, E -0.0366
CANX calnexin -0.0361587
TMSB10 thymosin beta 10 -0.0353558
RPL36A ribosomal protein L36a -0.0350281
LOC112694756 uncharaterized LOC112694756 -0.0343742
IFI16 interferon, gamma-inducible protein 16 -0.0339653
CDH13 cadherin 13 -0.0338666
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0328222
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0310223
BICC1 BicC family RNA binding protein 1 -0.0310176
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.030995
STC1 stanniocalcin 1 -0.0304469
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0297104
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0289173
KYNU kynureninase -0.0277648
EFNA5 ephrin-A5 -0.0272916
INTS6 integrator complex subunit 6 -0.0270129
ZMYND8 zinc finger, MYND-type containing 8 -0.0268986
RAI14 retinoic acid induced 14 -0.0264337
PNRC1 proline-rich nuclear receptor coactivator 1 -0.026205
EIF1 eukaryotic translation initiation factor 1 -0.0261844
RPLP1 ribosomal protein, large, P1 -0.0253955
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0252725
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0242154
MT2A metallothionein 2A -0.0241725
ZBTB38 zinc finger and BTB domain containing 38 -0.0240913
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0239043
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0236675
ZBTB20 zinc finger and BTB domain containing 20 -0.0234969
DIAPH2 diaphanous-related formin 2 -0.0233937
SLC38A1 solute carrier family 38, member 1 -0.023381
SP100 SP100 nuclear antigen -0.0228058
IGFBP3 insulin-like growth factor binding protein 3 -0.0227721
GPC6 glypican 6 -0.0227119
ASPH aspartate beta-hydroxylase -0.0226163
SOX5 SRY (sex determining region Y)-box 5 -0.0224313
ANKHD1 ankyrin repeat and KH domain containing 1 -0.021298
INHBA inhibin, beta A -0.0202825
SPDYA speedy/RINGO cell cycle regulator family member A -0.0202391
MORF4L2 mortality factor 4 like 2 -0.0198948
RPS25 ribosomal protein S25 -0.0198784
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0198661
RHOBTB3 Rho-related BTB domain containing 3 -0.0195693
OSBPL8 oxysterol binding protein-like 8 -0.0195663
FOXP1 forkhead box P1 -0.019225
RPL37 ribosomal protein L37 -0.0189969
FBXO11 F-box protein 11 -0.0189459
VDAC1 voltage-dependent anion channel 1 -0.018903
CDK13 cyclin-dependent kinase 13 -0.0187625
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0181234
KDM3A lysine (K)-specific demethylase 3A -0.0179196
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0177418
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0177264
GOLGB1 golgin B1 -0.0176957
RND3 Rho family GTPase 3 -0.0174917
AFF3 AF4/FMR2 family, member 3 -0.0174892
RPS23 ribosomal protein S23 -0.0172093
RTN3 reticulon 3 -0.0171834
RPS8 ribosomal protein S8 -0.017149
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0170292
MT1X metallothionein 1X -0.017017
BTBD9 BTB (POZ) domain containing 9 -0.0167962
GNAS GNAS complex locus -0.0167814
TMEM132D transmembrane protein 132D -0.0167668
ARL4C ADP-ribosylation factor-like 4C -0.0166699
AHI1 Abelson helper integration site 1 -0.0165253
HLA-B major histocompatibility complex, class I, B -0.0164897
CTSD cathepsin D -0.0163495
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0162339
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0161474
RPS16 ribosomal protein S16 -0.0161104
RPL39 ribosomal protein L39 -0.0160791
EHBP1 EH domain binding protein 1 -0.01603
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0159957
RPS13 ribosomal protein S13 -0.0157665
FOXO3 forkhead box O3 -0.0156598
FBXL7 F-box and leucine-rich repeat protein 7 -0.0156596
CLMP CXADR-like membrane protein -0.015627
SAMD3 sterile alpha motif domain containing 3 -0.0155742