Cilostazol_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.152641
VEGFA vascular endothelial growth factor A 0.132227
COL6A3 collagen, type VI, alpha 3 0.124182
EEF2 eukaryotic translation elongation factor 2 0.0658758
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0560258
FN1 fibronectin 1 0.0535815
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0533113
PDIA6 protein disulfide isomerase family A, member 6 0.0486564
PSD3 pleckstrin and Sec7 domain containing 3 0.0462817
IL6 interleukin 6 0.0461137
TMSB10 thymosin beta 10 0.0445097
PKM pyruvate kinase, muscle 0.0426831
PTMA prothymosin, alpha 0.0419117
RPL23 ribosomal protein L23 0.0416344
AKAP12 A kinase (PRKA) anchor protein 12 0.0412946
CDH13 cadherin 13 0.0405713
COL5A1 collagen, type V, alpha 1 0.0405029
IGF2 insulin-like growth factor 2 0.0402182
B2M beta-2-microglobulin 0.0394008
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0389731
VEGFC vascular endothelial growth factor C 0.037412
FTH1 ferritin, heavy polypeptide 1 0.0365882
ACTG1 actin gamma 1 0.0364458
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0362104
POTEF POTE ankyrin domain family, member F 0.0346118
METTL15 methyltransferase like 15 0.0339281
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.033377
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0330746
RPS19 ribosomal protein S19 0.0326735
LOC102724023 ES1 protein homolog, mitochondrial 0.0319692
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0319536
RPL12 ribosomal protein L12 0.0317353
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0314222
ZMIZ1 zinc finger, MIZ-type containing 1 0.0311544
RPLP2 ribosomal protein, large, P2 0.0308874
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0307393
PARD3 par-3 family cell polarity regulator 0.030308
NAP1L1 nucleosome assembly protein 1-like 1 0.0292262
SRRM2 serine/arginine repetitive matrix 2 0.0289766
NCOR2 nuclear receptor corepressor 2 0.0281205
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0276509
RPS8 ribosomal protein S8 0.0274883
ANLN anillin, actin binding protein 0.0273186
LOXL2 lysyl oxidase-like 2 0.0270679
MPRIP myosin phosphatase Rho interacting protein 0.0267371
ASXL1 additional sex combs like transcriptional regulator 1 0.0266775
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0265369
IGFBP7 insulin-like growth factor binding protein 7 0.0263077
F3 coagulation factor III (thromboplastin, tissue factor) 0.0261931
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0260923
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0258544
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0252618
GSE1 Gse1 coiled-coil protein 0.0251809
ZFHX3 zinc finger homeobox 3 0.025105
SERF2 small EDRK-rich factor 2 0.0250312
FNDC3A fibronectin type III domain containing 3A 0.0248417
MAP1B microtubule-associated protein 1B 0.0247342
TGFB1 transforming growth factor, beta 1 0.0245095
CKAP5 cytoskeleton associated protein 5 0.0243935
COL1A1 collagen, type I, alpha 1 0.0243756
RPL9 ribosomal protein L9 0.0243631
SYNPO synaptopodin 0.0243599
CST3 cystatin C 0.0243082
RPS3 ribosomal protein S3 0.024056
MAP2K1 mitogen-activated protein kinase kinase 1 0.0239026
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0237098
TENM3 teneurin transmembrane protein 3 0.023705
MYH9 myosin, heavy chain 9, non-muscle 0.0236358
ARRDC3 arrestin domain containing 3 0.0232404
RANBP2 RAN binding protein 2 0.0230093
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.022876
DEK DEK proto-oncogene 0.0227942
PTPRF protein tyrosine phosphatase, receptor type, F 0.022777
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0227732
RPS13 ribosomal protein S13 0.0227721
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0227408
MSN moesin 0.022731
SRSF4 serine/arginine-rich splicing factor 4 0.0225587
PABPN1 poly(A) binding protein, nuclear 1 0.0224933
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0224619
CORO1C coronin, actin binding protein, 1C 0.02226
MKI67 marker of proliferation Ki-67 0.022091
ADAM9 ADAM metallopeptidase domain 9 0.0219836
MCFD2 multiple coagulation factor deficiency 2 0.0219225
FMNL2 formin-like 2 0.0217572
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.021735
PICALM phosphatidylinositol binding clathrin assembly protein 0.0214994
STC2 stanniocalcin 2 0.0214432
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0214137
CKAP4 cytoskeleton-associated protein 4 0.0213899
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0212824
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0212658
SMC3 structural maintenance of chromosomes 3 0.0212134
ATP11A ATPase, class VI, type 11A 0.0211934
ARID1A AT rich interactive domain 1A (SWI-like) 0.0208443
TIMP3 TIMP metallopeptidase inhibitor 3 0.0205663
RO60 Ro60, Y RNA binding protein 0.0205419
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0205177
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0203731
TNS3 tensin 3 0.0203692

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.271389
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0872158
AKAP9 A kinase (PRKA) anchor protein 9 -0.076596
SOD2 superoxide dismutase 2, mitochondrial -0.0663902
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0656668
CALU calumenin -0.0604992
CANX calnexin -0.0590736
PRELID2 PRELI domain containing 2 -0.0563537
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0541796
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0537213
COL1A2 collagen, type I, alpha 2 -0.0517316
SEPTIN7 septin 7 -0.051316
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0495958
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0494665
TRA2A transformer 2 alpha homolog (Drosophila) -0.0466296
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0454236
VCL vinculin -0.0448572
RAB1A RAB1A, member RAS oncogene family -0.0442242
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.044141
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0433893
AHNAK AHNAK nucleoprotein -0.0432378
DPYD dihydropyrimidine dehydrogenase -0.0420756
SRP54 signal recognition particle 54kDa -0.040697
GLIS3 GLIS family zinc finger 3 -0.0391903
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0391377
UBE2H ubiquitin-conjugating enzyme E2H -0.0389164
FNDC3B fibronectin type III domain containing 3B -0.0384275
AVL9 AVL9 homolog (S. cerevisiase) -0.0378874
SEPTIN2 septin 2 -0.0373048
MARCHF6 membrane associated ring-CH-type finger 6 -0.0366151
GNAS GNAS complex locus -0.0366009
RTN4 reticulon 4 -0.0363847
AUTS2 autism susceptibility candidate 2 -0.0361986
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0360887
SEC31A SEC31 homolog A (S. cerevisiae) -0.035954
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0351513
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0347595
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0344409
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0340239
WASF2 WAS protein family, member 2 -0.0338899
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0336799
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0335636
NOP58 NOP58 ribonucleoprotein -0.0326392
ERRFI1 ERBB receptor feedback inhibitor 1 -0.032171
SMC5 structural maintenance of chromosomes 5 -0.0321531
TENT5A terminal nucleotidyltransferase 5A -0.0318353
RUNX1 runt-related transcription factor 1 -0.031789
CSNK1A1 casein kinase 1, alpha 1 -0.0314626
MARCHF7 membrane associated ring-CH-type finger 7 -0.031075
SCFD1 sec1 family domain containing 1 -0.0310436
IL6ST interleukin 6 signal transducer -0.0309905
TPM4 tropomyosin 4 -0.0304984
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0304387
GOLGA4 golgin A4 -0.0303117
UBC ubiquitin C -0.0302674
RAB2A RAB2A, member RAS oncogene family -0.0301957
CFDP1 craniofacial development protein 1 -0.0301579
HM13 histocompatibility (minor) 13 -0.0301409
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0299145
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0298156
H3-3B H3.3 histone B -0.0297936
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0296044
MBD5 methyl-CpG binding domain protein 5 -0.029597
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0295656
EPAS1 endothelial PAS domain protein 1 -0.0294509
NIPBL Nipped-B homolog (Drosophila) -0.0294024
ELL2 elongation factor, RNA polymerase II, 2 -0.0293575
ANKHD1 ankyrin repeat and KH domain containing 1 -0.029329
ZBTB20 zinc finger and BTB domain containing 20 -0.0292608
KLHDC10 kelch domain containing 10 -0.0292024
TAS2R14 taste receptor, type 2, member 14 -0.0291603
KDM5B lysine (K)-specific demethylase 5B -0.0290377
SDC4 syndecan 4 -0.0287453
PRRC1 proline-rich coiled-coil 1 -0.0286239
ANO6 anoctamin 6 -0.0282001
MTREX Mtr4 exosome RNA helicase -0.0281164
SFXN1 sideroflexin 1 -0.0280141
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0276691
EIF1 eukaryotic translation initiation factor 1 -0.0275144
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0274133
TARS1 threonyl-tRNA synthetase 1 -0.0270962
IFRD1 interferon-related developmental regulator 1 -0.0270584
TGFBI transforming growth factor, beta-induced, 68kDa -0.0269641
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0269085
SSBP2 single-stranded DNA binding protein 2 -0.0267647
ERBIN erbb2 interacting protein -0.0267162
TNPO3 transportin 3 -0.0266298
HLA-C major histocompatibility complex, class I, C -0.026608
HOOK2 hook microtubule-tethering protein 2 -0.0265363
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0263138
MON2 MON2 homolog (S. cerevisiae) -0.0262526
CIRSR corepressor of RBPJ and splicing regulator -0.026222
LMAN1 lectin, mannose-binding, 1 -0.0261916
SKIC3 SKI3 subunit of superkiller complex -0.0261514
SKAP2 src kinase associated phosphoprotein 2 -0.0259579
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0259046
GARS1 glycyl-tRNA synthetase 1 -0.0254841
TBC1D23 TBC1 domain family, member 23 -0.0254131
MARCKS myristoylated alanine-rich protein kinase C substrate -0.02508
FAM13A family with sequence similarity 13, member A -0.0247967