Cilostazol_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cilostazol perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cilostazol_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC2 stanniocalcin 2 0.0762258
NDRG1 N-myc downstream regulated 1 0.0704909
VEGFA vascular endothelial growth factor A 0.0663539
PTMA prothymosin, alpha 0.0640095
NRG1 neuregulin 1 0.0546726
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.053152
TRIO trio Rho guanine nucleotide exchange factor 0.046837
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0411725
NAMPT nicotinamide phosphoribosyltransferase 0.0392765
FTL ferritin, light polypeptide 0.0387236
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0386678
PKM pyruvate kinase, muscle 0.0376087
HLA-B major histocompatibility complex, class I, B 0.0371678
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0351262
MYH9 myosin, heavy chain 9, non-muscle 0.03345
MRPS6 mitochondrial ribosomal protein S6 0.033418
B2M beta-2-microglobulin 0.0333551
MT2A metallothionein 2A 0.0317089
SFTPA2 surfactant protein A2 0.0316536
ACTG1 actin gamma 1 0.0304542
TMSB10 thymosin beta 10 0.0298253
RPS3 ribosomal protein S3 0.0292294
ENO2 enolase 2 (gamma, neuronal) 0.0288705
PLIN2 perilipin 2 0.0288324
RPL37A ribosomal protein L37a 0.0285574
CXCL8 chemokine (C-X-C motif) ligand 8 0.0278912
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0273277
FAT1 FAT atypical cadherin 1 0.0272133
ENO1 enolase 1, (alpha) 0.0269385
MYOF myoferlin 0.0259081
LIMCH1 LIM and calponin homology domains 1 0.0255015
FLNA filamin A, alpha 0.0250273
CADM1 cell adhesion molecule 1 0.024392
TPT1 tumor protein, translationally-controlled 1 0.0242501
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0241667
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.024031
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0234733
RPL31 ribosomal protein L31 0.0233159
ZFP36L1 ZFP36 ring finger protein-like 1 0.0232188
ERRFI1 ERBB receptor feedback inhibitor 1 0.0226796
HILPDA hypoxia inducible lipid droplet-associated 0.0224504
FLNB filamin B, beta 0.0222547
INTS6 integrator complex subunit 6 0.0220344
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0217083
TMSB4X thymosin beta 4, X-linked 0.0215163
MCL1 myeloid cell leukemia 1 0.0208729
HSPA8 heat shock 70kDa protein 8 0.0207679
ESYT2 extended synaptotagmin-like protein 2 0.0206795
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0206264
RPL26 ribosomal protein L26 0.0205977
DDIT4 DNA-damage-inducible transcript 4 0.0199229
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0198568
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0197964
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0195395
ANKRD11 ankyrin repeat domain 11 0.0194469
EEF2 eukaryotic translation elongation factor 2 0.0192832
TFPI2 tissue factor pathway inhibitor 2 0.0191759
PDIA6 protein disulfide isomerase family A, member 6 0.0186629
CALR calreticulin 0.0186492
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0182318
RPS29 ribosomal protein S29 0.0181145
RPL9 ribosomal protein L9 0.017955
RPL23 ribosomal protein L23 0.0179207
RPS12 ribosomal protein S12 0.0174201
ZMIZ1 zinc finger, MIZ-type containing 1 0.0172844
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0171139
RPS23 ribosomal protein S23 0.0170824
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0169092
GRB10 growth factor receptor-bound protein 10 0.0163702
FAM13A family with sequence similarity 13, member A 0.0163232
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0162637
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0162459
RPS8 ribosomal protein S8 0.0161933
RACK1 receptor for activated C kinase 1 0.0161687
FOSL1 FOS-like antigen 1 0.0158804
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0155664
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0154405
SRRM2 serine/arginine repetitive matrix 2 0.0154226
ZNF292 zinc finger protein 292 0.0154086
CTBP2 C-terminal binding protein 2 0.0152709
CD109 CD109 molecule 0.0151814
ANXA2 annexin A2 0.0150572
PGK1 phosphoglycerate kinase 1 0.0150006
H1-0 H1.0 linker histone 0.0146315
SQSTM1 sequestosome 1 0.014572
STC1 stanniocalcin 1 0.0145256
MACF1 microtubule-actin crosslinking factor 1 0.0144784
RPS19 ribosomal protein S19 0.0144551
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.014355
HDGF hepatoma-derived growth factor 0.0143251
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0143173
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.014298
APP amyloid beta (A4) precursor protein 0.0142894
RPL36 ribosomal protein L36 0.014267
LRRC23 leucine rich repeat containing 23 0.014241
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0142078
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0138901
RYBP RING1 and YY1 binding protein 0.0136077
PTK2 protein tyrosine kinase 2 0.0134699
UBC ubiquitin C 0.0134364

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0821514
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0690177
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0631399
EXT1 exostosin glycosyltransferase 1 -0.0631332
OSMR oncostatin M receptor -0.0557474
VCL vinculin -0.048161
NTN4 netrin 4 -0.0477813
ITGA1 integrin, alpha 1 -0.0399486
SYT1 synaptotagmin I -0.0374618
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0369036
TMEM156 transmembrane protein 156 -0.0356772
NCOA7 nuclear receptor coactivator 7 -0.0344173
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0340536
FN1 fibronectin 1 -0.0326801
NRP1 neuropilin 1 -0.0323829
GLIS3 GLIS family zinc finger 3 -0.0309466
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0308282
NRIP1 nuclear receptor interacting protein 1 -0.0290797
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0290654
FNBP1 formin binding protein 1 -0.0290019
RAB31 RAB31, member RAS oncogene family -0.0285477
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0277198
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0271422
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0270685
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0252477
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.025029
JMJD1C jumonji domain containing 1C -0.0247593
FNDC3A fibronectin type III domain containing 3A -0.0243738
IFI16 interferon, gamma-inducible protein 16 -0.0243198
SOS1 son of sevenless homolog 1 (Drosophila) -0.0242234
ANKRD28 ankyrin repeat domain 28 -0.0238867
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0229332
OGA O-GlcNAcase -0.0223713
PELO pelota homolog (Drosophila) -0.0223201
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0222373
TOP1 topoisomerase (DNA) I -0.022172
NIPBL Nipped-B homolog (Drosophila) -0.0219994
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0219792
FOXP1 forkhead box P1 -0.0218715
ETNK1 ethanolamine kinase 1 -0.0217105
AOPEP aminopeptidase O (putative) -0.0212382
FAF2 Fas associated factor family member 2 -0.0199344
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0194661
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0192618
GCC2 GRIP and coiled-coil domain containing 2 -0.019241
FHL2 four and a half LIM domains 2 -0.0192288
AKAP9 A kinase (PRKA) anchor protein 9 -0.0191571
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0188657
ETV1 ets variant 1 -0.0188468
KSR1 kinase suppressor of ras 1 -0.0187708
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0186969
PALLD palladin, cytoskeletal associated protein -0.018649
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0182468
FTH1 ferritin, heavy polypeptide 1 -0.0181423
ADD3 adducin 3 (gamma) -0.0181343
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0179276
UBE2H ubiquitin-conjugating enzyme E2H -0.017807
ETV6 ets variant 6 -0.0177663
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.017738
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0176093
MBD5 methyl-CpG binding domain protein 5 -0.0175424
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.017524
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0174458
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0174194
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0172867
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0172805
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0169788
WWTR1 WW domain containing transcription regulator 1 -0.0166811
RIGI RNA sensor RIG-I -0.0166657
SMYD3 SET and MYND domain containing 3 -0.0166186
VMP1 vacuole membrane protein 1 -0.0162977
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0162497
ARF1 ADP-ribosylation factor 1 -0.0161781
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0159404
PTPRE protein tyrosine phosphatase, receptor type, E -0.0156485
EPN2 epsin 2 -0.015596
KLHL5 kelch-like family member 5 -0.0155819
TAS2R14 taste receptor, type 2, member 14 -0.0153991
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.015181
STRN3 striatin, calmodulin binding protein 3 -0.0151639
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0151629
MON2 MON2 homolog (S. cerevisiae) -0.015156
MCTP2 multiple C2 domains, transmembrane 2 -0.0148809
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0148204
ARHGAP5 Rho GTPase activating protein 5 -0.014795
CSNK1A1 casein kinase 1, alpha 1 -0.0146586
IL1R1 interleukin 1 receptor, type I -0.0145614
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0145029
FBXW11 F-box and WD repeat domain containing 11 -0.0143694
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0143199
PNISR PNN-interacting serine/arginine-rich protein -0.0142543
RAB10 RAB10, member RAS oncogene family -0.0142095
ZEB1 zinc finger E-box binding homeobox 1 -0.0142017
VCAN versican -0.014168
SVIL supervillin -0.0141136
USP15 ubiquitin specific peptidase 15 -0.0139296
ZNF644 zinc finger protein 644 -0.013769
FBXO28 F-box protein 28 -0.0137053
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0136147
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0135967