Cimetidine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. (Chemical Entities of Biological Interest Ontology, CHEBI_3699)
External Link http://ctdbase.org/detail.go?type=chem&acc=D002927
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Genes

63 genes/proteins interacting with the chemical Cimetidine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AHR aryl hydrocarbon receptor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APAF1 apoptotic peptidase activating factor 1
AR androgen receptor
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CTSD cathepsin D
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
EGFR epidermal growth factor receptor
FSHB follicle stimulating hormone, beta polypeptide
GAST gastrin
GSTP1 glutathione S-transferase pi 1
HMOX1 heme oxygenase 1
HRH2 histamine receptor H2
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL16 interleukin 16
IL18 interleukin 18
IL1B interleukin 1, beta
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
LRP1 low density lipoprotein receptor-related protein 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NTF3 neurotrophin 3
PRL prolactin
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
TNF tumor necrosis factor