| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. (Chemical Entities of Biological Interest Ontology, CHEBI_3699) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2756 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Cimetidine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RGN | regucalcin | 2.02 |
| ZFHX2 | zinc finger homeobox 2 | 1.37 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.98 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.7 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.66 |
| CHMP3 | charged multivesicular body protein 3 | 0.66 |
| ENO1 | enolase 1, (alpha) | 0.65 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.63 |
| CCDC57 | coiled-coil domain containing 57 | 0.6 |
| PTMA | prothymosin, alpha | 0.6 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.59 |
| RWDD1 | RWD domain containing 1 | 0.59 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.55 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.53 |
| GUCD1 | guanylyl cyclase domain containing 1 | 0.53 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | 0.53 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.51 |
| RPL36A | ribosomal protein L36a | 0.5 |
| RTL6 | retrotransposon Gag like 6 | 0.49 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.47 |
| TIPE1 | TNF alpha induced protein 8 like 1 | 0.47 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.47 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.46 |
| ZNF394 | zinc finger protein 394 | 0.44 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.43 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.43 |
| TOX2 | TOX high mobility group box family member 2 | 0.41 |
| MXRA7 | matrix-remodelling associated 7 | 0.41 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.41 |
| PTMS | parathymosin | 0.41 |
| LYST | lysosomal trafficking regulator | 0.4 |
| COMMD8 | COMM domain containing 8 | 0.4 |
| ARFGEF3 | ARFGEF family member 3 | 0.4 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.4 |
| SMO | smoothened, frizzled class receptor | 0.4 |
| HELQ | helicase, POLQ-like | 0.39 |
| SYNPO | synaptopodin | 0.39 |
| BDNF | brain-derived neurotrophic factor | 0.39 |
| CCDC43 | coiled-coil domain containing 43 | 0.39 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.38 |
| YIF1B | Yip1 interacting factor homolog B (S. cerevisiae) | 0.37 |
| LACTB | lactamase, beta | 0.37 |
| MYZAP | myocardial zonula adherens protein | 0.37 |
| ZNF250 | zinc finger protein 250 | 0.37 |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.37 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | 0.37 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.36 |
| PROSER3 | proline and serine rich 3 | 0.36 |
| IQCG | IQ motif containing G | 0.36 |
| METTL22 | methyltransferase like 22 | 0.36 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.35 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.35 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.35 |
| RPL36AL | ribosomal protein L36a-like | 0.34 |
| KLHL15 | kelch-like family member 15 | 0.34 |
| SURF2 | surfeit 2 | 0.34 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | 0.33 |
| TSEN15 | TSEN15 tRNA splicing endonuclease subunit | 0.33 |
| DPP4 | dipeptidyl-peptidase 4 | 0.33 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.33 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.33 |
| C1ORF109 | chromosome 1 open reading frame 109 | 0.33 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.32 |
| FAM124A | family with sequence similarity 124A | 0.32 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | 0.32 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.32 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | 0.32 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | 0.32 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.32 |
| GID8 | GID complex subunit 8 | 0.31 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | 0.31 |
| RGP1 | RGP1 retrograde golgi transport homolog (S. cerevisiae) | 0.31 |
| TRAPPC6A | trafficking protein particle complex 6A | 0.3 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.3 |
| PRRX2 | paired related homeobox 2 | 0.3 |
| RPS26 | ribosomal protein S26 | 0.29 |
| TCTN2 | tectonic family member 2 | 0.29 |
| RPL32 | ribosomal protein L32 | 0.29 |
| CEPT1 | choline/ethanolamine phosphotransferase 1 | 0.29 |
| RPLP1 | ribosomal protein, large, P1 | 0.29 |
| ATXN2 | ataxin 2 | 0.29 |
| EED | embryonic ectoderm development | 0.29 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | 0.29 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.29 |
| LIN7A | lin-7 homolog A (C. elegans) | 0.29 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | 0.28 |
| C5ORF22 | chromosome 5 open reading frame 22 | 0.28 |
| ADSS1 | adenylosuccinate synthase 1 | 0.28 |
| ZNF483 | zinc finger protein 483 | 0.28 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | 0.28 |
| COQ4 | coenzyme Q4 | 0.28 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.28 |
| RAD51 | RAD51 recombinase | 0.28 |
| RETREG2 | reticulophagy regulator family member 2 | 0.27 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | 0.27 |
| FN1 | fibronectin 1 | 0.27 |
| PRKCQ | protein kinase C, theta | 0.27 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | 0.27 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A | 0.27 |
| ABHD11 | abhydrolase domain containing 11 | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -2.16 |
| PSEN2 | presenilin 2 | -1.71 |
| ANKRD24 | ankyrin repeat domain 24 | -1.08 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.73 |
| NOTCH3 | notch 3 | -0.73 |
| SBSN | suprabasin | -0.7 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | -0.69 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.64 |
| RPAIN | RPA interacting protein | -0.55 |
| CDK14 | cyclin-dependent kinase 14 | -0.54 |
| BID | BH3 interacting domain death agonist | -0.54 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | -0.52 |
| MT1X | metallothionein 1X | -0.52 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.49 |
| BRD7 | bromodomain containing 7 | -0.48 |
| CUX2 | cut-like homeobox 2 | -0.47 |
| S100A6 | S100 calcium binding protein A6 | -0.47 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.45 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.45 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -0.44 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.43 |
| MFSD5 | major facilitator superfamily domain containing 5 | -0.43 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.41 |
| PRDX1 | peroxiredoxin 1 | -0.4 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.39 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.39 |
| CCNQ | cyclin Q | -0.39 |
| MAGEE1 | melanoma antigen family E1 | -0.38 |
| LSM7 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.38 |
| FKBPL | FK506 binding protein like | -0.38 |
| GABPB2 | GA binding protein transcription factor, beta subunit 2 | -0.37 |
| MAGEB1 | melanoma antigen family B1 | -0.37 |
| GLRX5 | glutaredoxin 5 | -0.37 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.37 |
| RPL37 | ribosomal protein L37 | -0.36 |
| CETN2 | centrin, EF-hand protein, 2 | -0.36 |
| H4C1 | H4 clustered histone 1 | -0.36 |
| APOE | apolipoprotein E | -0.36 |
| MTRF1 | mitochondrial translational release factor 1 | -0.35 |
| SUMO2 | small ubiquitin-like modifier 2 | -0.35 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.35 |
| SEPHS1 | selenophosphate synthetase 1 | -0.34 |
| SLC66A2 | solute carrier family 66 member 2 | -0.34 |
| C12ORF57 | chromosome 12 open reading frame 57 | -0.34 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | -0.34 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.33 |
| RNF26 | ring finger protein 26 | -0.33 |
| MFSD8 | major facilitator superfamily domain containing 8 | -0.33 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.33 |
| ARG2 | arginase 2 | -0.33 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -0.33 |
| ANTXR2 | anthrax toxin receptor 2 | -0.33 |
| INHBA | inhibin, beta A | -0.32 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.32 |
| TPM4 | tropomyosin 4 | -0.32 |
| PFDN2 | prefoldin subunit 2 | -0.32 |
| MARCKSL1 | MARCKS-like 1 | -0.31 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.31 |
| TLR9 | toll-like receptor 9 | -0.3 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.3 |
| ZNF652 | zinc finger protein 652 | -0.3 |
| FAM117B | family with sequence similarity 117, member B | -0.3 |
| FZD7 | frizzled class receptor 7 | -0.3 |
| SPPL2A | signal peptide peptidase like 2A | -0.29 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | -0.29 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.29 |
| F8 | coagulation factor VIII, procoagulant component | -0.29 |
| BOLA1 | bolA family member 1 | -0.29 |
| ITGA6 | integrin, alpha 6 | -0.28 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.28 |
| CINP | cyclin-dependent kinase 2 interacting protein | -0.28 |
| ZNF175 | zinc finger protein 175 | -0.28 |
| ZNF91 | zinc finger protein 91 | -0.28 |
| MRPL20 | mitochondrial ribosomal protein L20 | -0.28 |
| C17ORF53 | chromosome 17 open reading frame 53 | -0.28 |
| ZFAT | zinc finger and AT hook domain containing | -0.28 |
| ZNF431 | zinc finger protein 431 | -0.27 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.27 |
| TREX1 | three prime repair exonuclease 1 | -0.27 |
| FAM102A | family with sequence similarity 102, member A | -0.27 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | -0.27 |
| FAM174A | family with sequence similarity 174, member A | -0.27 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.27 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.26 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | -0.26 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.26 |
| TRIB3 | tribbles pseudokinase 3 | -0.26 |
| CALB2 | calbindin 2 | -0.26 |
| SUMO3 | small ubiquitin-like modifier 3 | -0.26 |
| CDC42 | cell division cycle 42 | -0.26 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.26 |
| HIST2H2AB | histone cluster 2, H2ab | -0.26 |
| MRPL35 | mitochondrial ribosomal protein L35 | -0.26 |
| METTL7A | methyltransferase like 7A | -0.26 |
| INO80D | INO80 complex subunit D | -0.26 |
| CMC4 | C-x(9)-C motif containing 4 | -0.25 |
| C11ORF95 | chromosome 11 open reading frame 95 | -0.25 |
| CBR3 | carbonyl reductase 3 | -0.25 |
| ATOX1 | antioxidant 1 copper chaperone | -0.25 |
