Cinacalcet_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.136655
FMN1 formin 1 0.121584
LSAMP limbic system-associated membrane protein 0.110802
MEIS2 Meis homeobox 2 0.0955077
EXT1 exostosin glycosyltransferase 1 0.0914885
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.09148
PTPRD protein tyrosine phosphatase, receptor type, D 0.0844859
ZSWIM6 zinc finger, SWIM-type containing 6 0.0688092
VMP1 vacuole membrane protein 1 0.0620402
BCAS3 breast carcinoma amplified sequence 3 0.0618212
TLE4 transducin-like enhancer of split 4 0.0578473
LPIN1 lipin 1 0.0553084
SYT1 synaptotagmin I 0.0508738
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0486548
PLPP1 phospholipid phosphatase 1 0.0483782
KLHL13 kelch-like family member 13 0.0477129
DST dystonin 0.0452741
FNDC3A fibronectin type III domain containing 3A 0.0446198
ZBTB20 zinc finger and BTB domain containing 20 0.0438087
GLCCI1 glucocorticoid induced 1 0.0430922
TRIB2 tribbles pseudokinase 2 0.042007
RNF213 ring finger protein 213 0.0419182
TPM1 tropomyosin 1 (alpha) 0.0401682
NRG1 neuregulin 1 0.0400914
LPP LIM domain containing preferred translocation partner in lipoma 0.0397648
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0394834
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0392723
TPST1 tyrosylprotein sulfotransferase 1 0.037983
AUTS2 autism susceptibility candidate 2 0.0379187
PLAT plasminogen activator, tissue 0.0379034
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0378959
SMYD3 SET and MYND domain containing 3 0.0378219
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0369372
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0363655
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0353268
SLIT2 slit homolog 2 (Drosophila) 0.035262
ANTXR1 anthrax toxin receptor 1 0.0352209
DSCAM Down syndrome cell adhesion molecule 0.0347335
PRKCA protein kinase C, alpha 0.034311
FNDC3B fibronectin type III domain containing 3B 0.0333909
THBS1 thrombospondin 1 0.033355
THSD4 thrombospondin, type I, domain containing 4 0.032948
MBNL2 muscleblind-like splicing regulator 2 0.0327086
NALF1 NALCN channel auxiliary factor 1 0.0321916
EEF2 eukaryotic translation elongation factor 2 0.0316912
MSI2 musashi RNA-binding protein 2 0.0313204
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0307561
SDK1 sidekick cell adhesion molecule 1 0.0305272
ANKRD17 ankyrin repeat domain 17 0.0298964
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0296312
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0294165
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0292489
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0286255
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0284446
MYO6 myosin VI 0.0281636
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0273496
GREM2 gremlin 2, DAN family BMP antagonist 0.0272091
TTC17 tetratricopeptide repeat domain 17 0.0260267
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0259715
ZFC3H1 zinc finger, C3H1-type containing 0.0258757
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0258544
MED13 mediator complex subunit 13 0.025829
FOXO3 forkhead box O3 0.0257509
STK38L serine/threonine kinase 38 like 0.0251468
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0251329
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0250598
RPTOR regulatory associated protein of MTOR, complex 1 0.0248993
ADAR adenosine deaminase, RNA-specific 0.0248678
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0247105
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0245158
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0242409
MED13L mediator complex subunit 13-like 0.024099
UNC5C unc-5 homolog C (C. elegans) 0.0240436
PHF3 PHD finger protein 3 0.0240027
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0237374
TCF12 transcription factor 12 0.0236763
DGKH diacylglycerol kinase, eta 0.0234126
ARHGAP5 Rho GTPase activating protein 5 0.0232889
FRMD4A FERM domain containing 4A 0.0232793
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0231067
NRIP1 nuclear receptor interacting protein 1 0.0229394
CENPF centromere protein F, 350/400kDa 0.0229189
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0229182
ADARB1 adenosine deaminase, RNA-specific, B1 0.0226404
COL3A1 collagen, type III, alpha 1 0.0223931
CPED1 cadherin-like and PC-esterase domain containing 1 0.0220098
PDE10A phosphodiesterase 10A 0.0219217
PDZRN3 PDZ domain containing ring finger 3 0.0218508
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0215274
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0214999
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0211072
NBEA neurobeachin 0.0208382
PSD3 pleckstrin and Sec7 domain containing 3 0.0206764
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0204461
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0204177
PBX1 pre-B-cell leukemia homeobox 1 0.0204082
DPH6 diphthamine biosynthesis 6 0.0202703
HSPA8 heat shock 70kDa protein 8 0.0201903
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.020148
RAD51B RAD51 paralog B 0.0201178

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.193928
PTMA prothymosin, alpha -0.0780238
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0524317
FTL ferritin, light polypeptide -0.0480195
RPS6 ribosomal protein S6 -0.043568
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0435169
TMSB10 thymosin beta 10 -0.0395822
RPL19 ribosomal protein L19 -0.0394416
VIM vimentin -0.0389292
GDF15 growth differentiation factor 15 -0.0386838
RPL23 ribosomal protein L23 -0.038323
RPL35A ribosomal protein L35a -0.0375652
NDRG1 N-myc downstream regulated 1 -0.0352562
RPS3 ribosomal protein S3 -0.0344152
RTN4 reticulon 4 -0.0343105
RPL34 ribosomal protein L34 -0.0308621
RPLP1 ribosomal protein, large, P1 -0.0300892
ZNF292 zinc finger protein 292 -0.0284158
TPT1 tumor protein, translationally-controlled 1 -0.0275655
STC1 stanniocalcin 1 -0.0270935
RPS19 ribosomal protein S19 -0.0261361
CEMIP cell migration inducing protein, hyaluronan binding -0.0256234
NAMPT nicotinamide phosphoribosyltransferase -0.0253719
RPS12 ribosomal protein S12 -0.0251785
RPS8 ribosomal protein S8 -0.023805
HMGA1 high mobility group AT-hook 1 -0.0221449
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0219104
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0217492
PKM pyruvate kinase, muscle -0.0213809
MAP1B microtubule-associated protein 1B -0.0213142
RPS24 ribosomal protein S24 -0.0210246
DSTN destrin (actin depolymerizing factor) -0.0207611
RACK1 receptor for activated C kinase 1 -0.0197613
RPL38 ribosomal protein L38 -0.0195984
RPL18 ribosomal protein L18 -0.0195239
RPS14 ribosomal protein S14 -0.0191504
RPL10A ribosomal protein L10a -0.0187341
RPL35 ribosomal protein L35 -0.0186368
RPL36 ribosomal protein L36 -0.018633
IGFBP3 insulin-like growth factor binding protein 3 -0.0185034
RPS27A ribosomal protein S27a -0.0184733
MEF2A myocyte enhancer factor 2A -0.0183987
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0182885
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0177662
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.017725
VDAC1 voltage-dependent anion channel 1 -0.0176888
ALCAM activated leukocyte cell adhesion molecule -0.0176624
GARS1 glycyl-tRNA synthetase 1 -0.016954
MAML2 mastermind-like 2 (Drosophila) -0.0165818
RNF145 ring finger protein 145 -0.0161201
GALP galanin-like peptide -0.0160864
RPLP2 ribosomal protein, large, P2 -0.0160501
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0156444
COPA coatomer protein complex, subunit alpha -0.0155977
ADM adrenomedullin -0.0155756
KDM5B lysine (K)-specific demethylase 5B -0.0154042
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0153159
PIAS2 protein inhibitor of activated STAT, 2 -0.0150564
IGFBP4 insulin-like growth factor binding protein 4 -0.0149442
SOX4 SRY (sex determining region Y)-box 4 -0.014851
RPS29 ribosomal protein S29 -0.0147485
MTSS2 MTSS I-BAR domain containing 2 -0.014665
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0146539
IER3 immediate early response 3 -0.0145762
RPL27 ribosomal protein L27 -0.0145488
ENO1 enolase 1, (alpha) -0.0145155
SCG2 secretogranin II -0.0144737
PA2G4 proliferation-associated 2G4, 38kDa -0.0144678
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0144478
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0143999
RIOK3 RIO kinase 3 -0.0142167
S100A9 S100 calcium binding protein A9 -0.0141717
CBX1 chromobox homolog 1 -0.0140683
FTH1 ferritin, heavy polypeptide 1 -0.0140404
LMNA lamin A/C -0.0140098
TNIP1 TNFAIP3 interacting protein 1 -0.0137636
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0137399
S100A6 S100 calcium binding protein A6 -0.0137087
HLA-A major histocompatibility complex, class I, A -0.0136274
PDIA3 protein disulfide isomerase family A, member 3 -0.0134645
RPS17 ribosomal protein S17 -0.0133335
RAB6A RAB6A, member RAS oncogene family -0.0130874
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0130411
ADNP activity-dependent neuroprotector homeobox -0.0130039
B2M beta-2-microglobulin -0.0130036
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0128966
RPL13A ribosomal protein L13a -0.0128713
NPTX1 neuronal pentraxin I -0.0128342
PLIN2 perilipin 2 -0.0128086
ZNF148 zinc finger protein 148 -0.0128059
GOLGA4 golgin A4 -0.0127585
RPL37A ribosomal protein L37a -0.0127574
LIMCH1 LIM and calponin homology domains 1 -0.012713
GNAS GNAS complex locus -0.0127033
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0126763
LAMB1 laminin, beta 1 -0.0126535
RARA retinoic acid receptor, alpha -0.0125767
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0125591
RPS25 ribosomal protein S25 -0.0125565
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0124886