Cinacalcet_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 0.0759961
DSCAM Down syndrome cell adhesion molecule 0.0684858
LMO7 LIM domain 7 0.0637693
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0596586
MBNL2 muscleblind-like splicing regulator 2 0.0573273
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.045838
MACC1 metastasis associated in colon cancer 1 0.0402659
SPATA13 spermatogenesis associated 13 0.0398459
EXT1 exostosin glycosyltransferase 1 0.0380629
PHF3 PHD finger protein 3 0.0374871
TRIM2 tripartite motif containing 2 0.0295276
CANX calnexin 0.0294717
FNDC3A fibronectin type III domain containing 3A 0.0286475
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0280174
STK24 serine/threonine kinase 24 0.0274019
FNIP1 folliculin interacting protein 1 0.0271349
UBE2H ubiquitin-conjugating enzyme E2H 0.0266694
NKD1 naked cuticle homolog 1 (Drosophila) 0.0264708
PRKCA protein kinase C, alpha 0.0258059
SMAD3 SMAD family member 3 0.0257345
SERINC5 serine incorporator 5 0.0257147
ANKRD10 ankyrin repeat domain 10 0.0257111
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0253912
NCKAP5 NCK-associated protein 5 0.0253638
EPS8 epidermal growth factor receptor pathway substrate 8 0.025246
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0239579
FNDC3B fibronectin type III domain containing 3B 0.0238171
STK39 serine threonine kinase 39 0.0237838
ZMYND8 zinc finger, MYND-type containing 8 0.0233391
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0229943
RUNX1 runt-related transcription factor 1 0.0229009
IFNGR1 interferon gamma receptor 1 0.0224233
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.022422
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0221449
UBAC2 UBA domain containing 2 0.0221185
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0219384
MYO1E myosin IE 0.021509
TJP2 tight junction protein 2 0.0210261
ATP11A ATPase, class VI, type 11A 0.020947
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0209463
MAN1A1 mannosidase, alpha, class 1A, member 1 0.020858
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0208347
ABHD2 abhydrolase domain containing 2 0.0207579
RAD51B RAD51 paralog B 0.0206164
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0201887
GSK3B glycogen synthase kinase 3 beta 0.019748
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0196666
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0196657
ARHGAP26 Rho GTPase activating protein 26 0.0196359
SREBF2 sterol regulatory element binding transcription factor 2 0.0195217
GRK3 G protein-coupled receptor kinase 3 0.0194661
ZBTB20 zinc finger and BTB domain containing 20 0.0194371
UBL3 ubiquitin-like 3 0.0193086
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0187146
MEIS2 Meis homeobox 2 0.0183476
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0181575
LPP LIM domain containing preferred translocation partner in lipoma 0.0181057
USP54 ubiquitin specific peptidase 54 0.0180928
PATJ PATJ crumbs cell polarity complex component 0.0180294
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0177333
TUT7 terminal uridylyl transferase 7 0.0176458
MCTP2 multiple C2 domains, transmembrane 2 0.0175644
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.017539
SAMD4A sterile alpha motif domain containing 4A 0.0172901
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0172179
TMEM39A transmembrane protein 39A 0.0172087
MLPH melanophilin 0.017179
ATP10B ATPase, class V, type 10B 0.0171514
MSI2 musashi RNA-binding protein 2 0.0167919
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0167793
ATXN1 ataxin 1 0.0167575
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0166496
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0163688
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0162158
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0160174
ETV6 ets variant 6 0.0157216
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.015632
FAT1 FAT atypical cadherin 1 0.0154754
FNIP2 folliculin interacting protein 2 0.0153705
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0152935
IGF1R insulin-like growth factor 1 receptor 0.015185
ARHGAP5 Rho GTPase activating protein 5 0.0150281
DUSP16 dual specificity phosphatase 16 0.0150256
FMN1 formin 1 0.014787
PRKG1 protein kinase, cGMP-dependent, type I 0.0147534
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0147179
NRIP1 nuclear receptor interacting protein 1 0.0147066
USP53 ubiquitin specific peptidase 53 0.0146314
TMEM62 transmembrane protein 62 0.0145309
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0145288
ASPH aspartate beta-hydroxylase 0.0145007
AHI1 Abelson helper integration site 1 0.0144542
CLTC clathrin, heavy chain (Hc) 0.0144456
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0144406
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0143955
KDM4C lysine (K)-specific demethylase 4C 0.0142933
AFF4 AF4/FMR2 family, member 4 0.0142765
DSPP dentin sialophosphoprotein 0.0141699
ADD3 adducin 3 (gamma) 0.0138648
AOPEP aminopeptidase O (putative) 0.0137962

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.159402
TPT1 tumor protein, translationally-controlled 1 -0.134726
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127314
PTMA prothymosin, alpha -0.091447
RPS6 ribosomal protein S6 -0.0789866
FTL ferritin, light polypeptide -0.0779922
LCN2 lipocalin 2 -0.0766708
RPL35A ribosomal protein L35a -0.0722871
IFI6 interferon, alpha-inducible protein 6 -0.0668749
TMSB10 thymosin beta 10 -0.0651858
HLA-B major histocompatibility complex, class I, B -0.0642141
RPL23 ribosomal protein L23 -0.0631765
EGR1 early growth response 1 -0.0580959
EIF1 eukaryotic translation initiation factor 1 -0.0532446
RPLP1 ribosomal protein, large, P1 -0.0531911
IFI27 interferon, alpha-inducible protein 27 -0.0523463
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0490283
MT2A metallothionein 2A -0.0488528
PKM pyruvate kinase, muscle -0.0484219
LOC102724023 ES1 protein homolog, mitochondrial -0.047654
C6ORF132 chromosome 6 open reading frame 132 -0.0469264
ACTG1 actin gamma 1 -0.0468856
RPS8 ribosomal protein S8 -0.0450402
RPL37A ribosomal protein L37a -0.0426815
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0426057
NDRG1 N-myc downstream regulated 1 -0.0406238
RPS19 ribosomal protein S19 -0.0404412
RPL31 ribosomal protein L31 -0.0400234
RPL34 ribosomal protein L34 -0.0383952
RPS3 ribosomal protein S3 -0.0375002
AREG amphiregulin -0.037414
RPL19 ribosomal protein L19 -0.0368173
RPS27 ribosomal protein S27 -0.0361487
RPL9 ribosomal protein L9 -0.032423
S100A10 S100 calcium binding protein A10 -0.0317919
RPL11 ribosomal protein L11 -0.0312553
RPLP2 ribosomal protein, large, P2 -0.0312338
RPL12 ribosomal protein L12 -0.0311532
DSTN destrin (actin depolymerizing factor) -0.0310795
PERP PERP, TP53 apoptosis effector -0.0299364
RPS29 ribosomal protein S29 -0.0298052
IFITM3 interferon induced transmembrane protein 3 -0.0293833
FTH1 ferritin, heavy polypeptide 1 -0.0292583
LYZ lysozyme -0.0282653
RPS12 ribosomal protein S12 -0.0276496
S100P S100 calcium binding protein P -0.0276492
S100A6 S100 calcium binding protein A6 -0.0275465
RPS13 ribosomal protein S13 -0.0273746
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0273713
TPI1 triosephosphate isomerase 1 -0.0272552
CST3 cystatin C -0.0271413
LDHA lactate dehydrogenase A -0.0268521
POTEF POTE ankyrin domain family, member F -0.0268187
CSTB cystatin B (stefin B) -0.026627
RPLP0 ribosomal protein, large, P0 -0.0260379
RPL37 ribosomal protein L37 -0.0258176
VIM vimentin -0.0253701
RPL38 ribosomal protein L38 -0.0251876
RPS23 ribosomal protein S23 -0.0248615
CLDN4 claudin 4 -0.024637
ENO1 enolase 1, (alpha) -0.0241589
S100A9 S100 calcium binding protein A9 -0.0239416
RPL28 ribosomal protein L28 -0.0238821
RPL36 ribosomal protein L36 -0.0238741
RPS24 ribosomal protein S24 -0.0238256
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0236367
RPS17 ribosomal protein S17 -0.0236361
RPS16 ribosomal protein S16 -0.0235445
RPS14 ribosomal protein S14 -0.0229775
INTS6 integrator complex subunit 6 -0.0228635
HMGB1 high mobility group box 1 -0.0226127
ANXA2 annexin A2 -0.0225575
RPL26 ribosomal protein L26 -0.0225143
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0221771
ATF4 activating transcription factor 4 -0.0221136
RPL30 ribosomal protein L30 -0.0219622
RPS25 ribosomal protein S25 -0.0218483
SLC38A1 solute carrier family 38, member 1 -0.0218312
ENO2 enolase 2 (gamma, neuronal) -0.0217973
HLA-C major histocompatibility complex, class I, C -0.0215957
RPS20 ribosomal protein S20 -0.0214274
LOC112694756 uncharaterized LOC112694756 -0.0211875
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0210649
KRT19 keratin 19, type I -0.0210212
ISG15 ISG15 ubiquitin-like modifier -0.020868
RPL18 ribosomal protein L18 -0.020632
FOSL1 FOS-like antigen 1 -0.020227
LMNA lamin A/C -0.0201966
RPL35 ribosomal protein L35 -0.0201704
S100A11 S100 calcium binding protein A11 -0.0201088
RACK1 receptor for activated C kinase 1 -0.0199605
TPM4 tropomyosin 4 -0.0199421
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0198453
RPS21 ribosomal protein S21 -0.0195698
MX2 MX dynamin-like GTPase 2 -0.0194691
IRF1 interferon regulatory factor 1 -0.0193162
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0192187
RPL8 ribosomal protein L8 -0.0190939
RPL7 ribosomal protein L7 -0.0190117
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0190056