Cinacalcet_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.270008
VEGFA vascular endothelial growth factor A 0.142615
TRIO trio Rho guanine nucleotide exchange factor 0.126644
IGFBP3 insulin-like growth factor binding protein 3 0.116
LOXL2 lysyl oxidase-like 2 0.0924026
COL6A3 collagen, type VI, alpha 3 0.0910732
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0906668
CADM1 cell adhesion molecule 1 0.0871164
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0825095
FN1 fibronectin 1 0.0791022
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0739258
PDE10A phosphodiesterase 10A 0.072404
TGFBI transforming growth factor, beta-induced, 68kDa 0.0661066
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0640212
GOLGA4 golgin A4 0.0624325
ATP13A3 ATPase type 13A3 0.0614969
JARID2 jumonji, AT rich interactive domain 2 0.0598192
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0557438
CXCL8 chemokine (C-X-C motif) ligand 8 0.0550596
FNDC3B fibronectin type III domain containing 3B 0.0530959
NAV2 neuron navigator 2 0.0510311
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.049534
MYH9 myosin, heavy chain 9, non-muscle 0.0479369
CAMTA1 calmodulin binding transcription activator 1 0.0458046
ESYT2 extended synaptotagmin-like protein 2 0.0426423
DPYSL2 dihydropyrimidinase-like 2 0.0399978
DLG1 discs, large homolog 1 (Drosophila) 0.0397078
ARRDC3 arrestin domain containing 3 0.03881
MTSS1 metastasis suppressor 1 0.0377568
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0377251
MRTFA myocardin related transcription factor A 0.0375357
CD109 CD109 molecule 0.0349758
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0348513
ADAM17 ADAM metallopeptidase domain 17 0.0346885
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0343844
RAB6A RAB6A, member RAS oncogene family 0.0340643
SPAG9 sperm associated antigen 9 0.0331547
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.032671
ANKRD11 ankyrin repeat domain 11 0.0325807
MYO9B myosin IXB 0.0323087
FMNL2 formin-like 2 0.0312933
COL6A1 collagen, type VI, alpha 1 0.0306851
TNS1 tensin 1 0.0305991
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0303362
UBA6 ubiquitin-like modifier activating enzyme 6 0.0302853
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0301265
DOCK5 dedicator of cytokinesis 5 0.0296537
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0289606
NOTCH2 notch 2 0.0289403
KMT2C lysine (K)-specific methyltransferase 2C 0.0285572
NKTR natural killer cell triggering receptor 0.0281372
HOOK2 hook microtubule-tethering protein 2 0.0280856
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0279766
SETD5 SET domain containing 5 0.0279008
CMIP c-Maf inducing protein 0.0266664
HIP1 huntingtin interacting protein 1 0.0266649
COG5 component of oligomeric golgi complex 5 0.0265605
EEF2 eukaryotic translation elongation factor 2 0.0265511
KDM7A lysine (K)-specific demethylase 7A 0.0260124
TMEM165 transmembrane protein 165 0.0258508
SUCO SUN domain containing ossification factor 0.0258494
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.025224
RASA2 RAS p21 protein activator 2 0.0251314
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0251178
SEC24A SEC24 family member A 0.0247759
CCNY cyclin Y 0.0247329
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0246937
BIRC6 baculoviral IAP repeat containing 6 0.0245767
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0245452
SMAD3 SMAD family member 3 0.0244254
PLEC plectin 0.0244232
HELZ helicase with zinc finger 0.0243624
COPA coatomer protein complex, subunit alpha 0.0242472
SRP54 signal recognition particle 54kDa 0.0239856
SOD2 superoxide dismutase 2, mitochondrial 0.0237155
LIMS1 LIM and senescent cell antigen-like domains 1 0.023552
PGM3 phosphoglucomutase 3 0.0235239
BBX bobby sox homolog (Drosophila) 0.0234509
KDM4C lysine (K)-specific demethylase 4C 0.0234148
CHD1 chromodomain helicase DNA binding protein 1 0.0233527
KMT2E lysine (K)-specific methyltransferase 2E 0.0233094
GRB10 growth factor receptor-bound protein 10 0.0230678
RLF rearranged L-myc fusion 0.0228845
ZNF292 zinc finger protein 292 0.0225752
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0224828
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0224536
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0222824
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0222674
KDM2A lysine (K)-specific demethylase 2A 0.0220926
FAM13A family with sequence similarity 13, member A 0.0218123
FNIP1 folliculin interacting protein 1 0.0216853
KIF1B kinesin family member 1B 0.0215337
RICTOR RPTOR independent companion of MTOR, complex 2 0.0215205
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0213268
ELL2 elongation factor, RNA polymerase II, 2 0.0209555
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0209396
ZCCHC7 zinc finger, CCHC domain containing 7 0.0207601
FAM219A family with sequence similarity 219, member A 0.0207591
TBC1D23 TBC1 domain family, member 23 0.0207355
CABIN1 calcineurin binding protein 1 0.020705

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.203864
COL1A1 collagen, type I, alpha 1 -0.192085
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.164095
TMSB10 thymosin beta 10 -0.12871
MT2A metallothionein 2A -0.124585
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0959268
FTL ferritin, light polypeptide -0.0819495
PTMA prothymosin, alpha -0.0789466
COL1A2 collagen, type I, alpha 2 -0.0662018
RPS8 ribosomal protein S8 -0.0604492
ACTG1 actin gamma 1 -0.0551032
RPL35A ribosomal protein L35a -0.054688
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.051835
RPS6 ribosomal protein S6 -0.0511623
CD44 CD44 molecule (Indian blood group) -0.0507476
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0504871
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0495717
ENO1 enolase 1, (alpha) -0.047163
CALD1 caldesmon 1 -0.045765
GLIS3 GLIS family zinc finger 3 -0.0456639
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0452157
IER3 immediate early response 3 -0.0449055
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0444284
HMGA2 high mobility group AT-hook 2 -0.0423813
RPS19 ribosomal protein S19 -0.0413242
ASPH aspartate beta-hydroxylase -0.0411628
RPL19 ribosomal protein L19 -0.0396232
VCAN versican -0.0389449
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0387088
IGFBP7 insulin-like growth factor binding protein 7 -0.037103
RPL12 ribosomal protein L12 -0.0366873
RPL26 ribosomal protein L26 -0.0365526
B2M beta-2-microglobulin -0.0363663
RPL23 ribosomal protein L23 -0.0354654
RPLP1 ribosomal protein, large, P1 -0.0349064
RACK1 receptor for activated C kinase 1 -0.0346364
VCL vinculin -0.0343652
LDHA lactate dehydrogenase A -0.0342893
CALR calreticulin -0.0341354
RPL11 ribosomal protein L11 -0.0338077
RPL36 ribosomal protein L36 -0.0335203
HLA-B major histocompatibility complex, class I, B -0.0326693
EXT1 exostosin glycosyltransferase 1 -0.0326584
CAVIN1 caveolae associated protein 1 -0.0326091
RPS3 ribosomal protein S3 -0.0324302
PALLD palladin, cytoskeletal associated protein -0.0322876
RPL8 ribosomal protein L8 -0.0313497
OSMR oncostatin M receptor -0.0312498
S100A9 S100 calcium binding protein A9 -0.0310924
TRPS1 trichorhinophalangeal syndrome I -0.0306192
LOC112694756 uncharaterized LOC112694756 -0.0305098
ALCAM activated leukocyte cell adhesion molecule -0.0302429
RRBP1 ribosome binding protein 1 -0.0300957
TMSB4X thymosin beta 4, X-linked -0.0295214
DPYD dihydropyrimidine dehydrogenase -0.0291887
TPT1 tumor protein, translationally-controlled 1 -0.0291492
ANXA2 annexin A2 -0.0283747
INHBA inhibin, beta A -0.0279806
TPM4 tropomyosin 4 -0.0272364
S100A6 S100 calcium binding protein A6 -0.0271762
ZBTB20 zinc finger and BTB domain containing 20 -0.0271671
YBX1 Y box binding protein 1 -0.0271446
IL6ST interleukin 6 signal transducer -0.0269203
TPI1 triosephosphate isomerase 1 -0.026882
AHNAK AHNAK nucleoprotein -0.026829
RPL13A ribosomal protein L13a -0.0268254
IFITM3 interferon induced transmembrane protein 3 -0.0264604
RPL34 ribosomal protein L34 -0.0263311
PFN1 profilin 1 -0.025583
IFI6 interferon, alpha-inducible protein 6 -0.0251462
PRSS23 protease, serine, 23 -0.0247424
EGR1 early growth response 1 -0.0234076
MBNL1 muscleblind-like splicing regulator 1 -0.0232196
RAD21 RAD21 homolog (S. pombe) -0.0231573
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0229396
TPM1 tropomyosin 1 (alpha) -0.0225788
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0225172
RPS13 ribosomal protein S13 -0.02238
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0223663
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0222559
RPL32 ribosomal protein L32 -0.0218945
S100A10 S100 calcium binding protein A10 -0.02176
FTH1 ferritin, heavy polypeptide 1 -0.021728
RPS20 ribosomal protein S20 -0.0216921
RPL28 ribosomal protein L28 -0.0215164
NREP neuronal regeneration related protein -0.0214716
RIGI RNA sensor RIG-I -0.0214429
RPL30 ribosomal protein L30 -0.021386
LIMA1 LIM domain and actin binding 1 -0.0213292
CNTN5 contactin 5 -0.0212692
RPL7 ribosomal protein L7 -0.021078
RPL5 ribosomal protein L5 -0.0210448
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0209529
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0208381
CAV1 caveolin 1, caveolae protein, 22kDa -0.02083
RPLP2 ribosomal protein, large, P2 -0.0204772
RPS21 ribosomal protein S21 -0.0203186
PDE4D phosphodiesterase 4D, cAMP-specific -0.0200082
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.0199922
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0199804