Cinacalcet_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.118098
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0981762
FNDC3B fibronectin type III domain containing 3B 0.0916869
ERRFI1 ERBB receptor feedback inhibitor 1 0.0894821
DSPP dentin sialophosphoprotein 0.0837649
C3 complement component 3 0.0661679
PEG3 paternally expressed 3 0.0583762
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0488425
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.048167
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.044273
SAMD4A sterile alpha motif domain containing 4A 0.0433173
EEF2 eukaryotic translation elongation factor 2 0.0432176
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0411583
AFDN afadin, adherens junction formation factor 0.0408631
PCBP2 poly(rC) binding protein 2 0.0406608
VEGFA vascular endothelial growth factor A 0.0400903
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.037131
MBNL2 muscleblind-like splicing regulator 2 0.0357975
SESTD1 SEC14 and spectrin domains 1 0.0351421
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0341774
PTPRM protein tyrosine phosphatase, receptor type, M 0.0337761
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0322987
DDIT4 DNA-damage-inducible transcript 4 0.0302031
DLC1 DLC1 Rho GTPase activating protein 0.0281798
TNS1 tensin 1 0.0281478
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0279257
DTNA dystrobrevin, alpha 0.0275492
MYH9 myosin, heavy chain 9, non-muscle 0.026765
EML4 echinoderm microtubule associated protein like 4 0.0254488
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0253656
ADAM9 ADAM metallopeptidase domain 9 0.0250968
TF transferrin 0.0246354
WDFY2 WD repeat and FYVE domain containing 2 0.0244143
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0243491
DST dystonin 0.0243384
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0239936
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0237002
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0227855
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0226304
APLP2 amyloid beta (A4) precursor-like protein 2 0.0225343
GMDS GDP-mannose 4,6-dehydratase 0.0219719
IGF2 insulin-like growth factor 2 0.0206788
A2M alpha-2-macroglobulin 0.0206396
MAML2 mastermind-like 2 (Drosophila) 0.0205824
MBNL1 muscleblind-like splicing regulator 1 0.0203552
CRY1 cryptochrome circadian clock 1 0.0199484
UBA6 ubiquitin-like modifier activating enzyme 6 0.0197195
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.019578
RUNX1 runt-related transcription factor 1 0.0195491
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0191474
TMEM123 transmembrane protein 123 0.019137
MACF1 microtubule-actin crosslinking factor 1 0.0190847
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0189385
RPL3 ribosomal protein L3 0.018739
PLIN2 perilipin 2 0.0187162
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0187149
INSIG2 insulin induced gene 2 0.0185397
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0185203
ARHGAP26 Rho GTPase activating protein 26 0.0181093
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0179979
AHR aryl hydrocarbon receptor 0.0176404
PDLIM5 PDZ and LIM domain 5 0.017291
EHBP1 EH domain binding protein 1 0.0171091
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0169174
TRIO trio Rho guanine nucleotide exchange factor 0.0168886
WWC2 WW and C2 domain containing 2 0.0168244
EIF3A eukaryotic translation initiation factor 3, subunit A 0.016776
PICALM phosphatidylinositol binding clathrin assembly protein 0.0166751
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0165976
NRIP1 nuclear receptor interacting protein 1 0.0163175
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0162836
USP34 ubiquitin specific peptidase 34 0.0162477
USP6NL USP6 N-terminal like 0.0160754
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0156006
ELL2 elongation factor, RNA polymerase II, 2 0.0154707
SOD2 superoxide dismutase 2, mitochondrial 0.015399
KDM7A lysine (K)-specific demethylase 7A 0.0153829
ASPH aspartate beta-hydroxylase 0.0153177
MYO1B myosin IB 0.015306
DSCAM Down syndrome cell adhesion molecule 0.0152412
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0152083
RB1CC1 RB1-inducible coiled-coil 1 0.0151712
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0150971
ARRDC3 arrestin domain containing 3 0.0149682
MYO6 myosin VI 0.0149619
APOB apolipoprotein B 0.014877
MSI2 musashi RNA-binding protein 2 0.0148671
KDM6A lysine (K)-specific demethylase 6A 0.0147697
GLS2 glutaminase 2 (liver, mitochondrial) 0.0147177
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0145833
NFE2L1 nuclear factor, erythroid 2-like 1 0.0143125
ADGRG6 adhesion G protein-coupled receptor G6 0.0142382
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0141062
ARHGAP9 Rho GTPase activating protein 9 0.0140986
PCGF5 polycomb group ring finger 5 0.0140976
GK glycerol kinase 0.0139969
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0139625
FBF1 Fas (TNFRSF6) binding factor 1 0.0139153
ARHGAP12 Rho GTPase activating protein 12 0.0139028
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0138825

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.278758
TPT1 tumor protein, translationally-controlled 1 -0.140597
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137376
TIMP1 TIMP metallopeptidase inhibitor 1 -0.136437
IGFBP1 insulin-like growth factor binding protein 1 -0.119776
RPL11 ribosomal protein L11 -0.101634
RPLP1 ribosomal protein, large, P1 -0.0999416
RPS6 ribosomal protein S6 -0.0887025
RPS24 ribosomal protein S24 -0.0866209
APOA2 apolipoprotein A-II -0.0863514
RPL37A ribosomal protein L37a -0.084713
FTL ferritin, light polypeptide -0.0832169
RPS19 ribosomal protein S19 -0.0792965
RPL23 ribosomal protein L23 -0.0790459
RPS8 ribosomal protein S8 -0.0740783
RPL35A ribosomal protein L35a -0.0690247
RPL31 ribosomal protein L31 -0.0660403
RPLP2 ribosomal protein, large, P2 -0.064621
TMSB10 thymosin beta 10 -0.0642116
RPS12 ribosomal protein S12 -0.0633635
RPL34 ribosomal protein L34 -0.0618908
RPL26 ribosomal protein L26 -0.0602251
GPC3 glypican 3 -0.057498
RPS21 ribosomal protein S21 -0.0547748
RPS29 ribosomal protein S29 -0.0503745
RPS27A ribosomal protein S27a -0.0501474
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0477878
RPS3 ribosomal protein S3 -0.0477238
RPS13 ribosomal protein S13 -0.047453
RPL38 ribosomal protein L38 -0.0457526
RPL12 ribosomal protein L12 -0.0451765
RPL5 ribosomal protein L5 -0.0445871
RPS23 ribosomal protein S23 -0.0433361
RPS10 ribosomal protein S10 -0.0426604
RPS14 ribosomal protein S14 -0.0424745
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0414312
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0412077
RPL32 ribosomal protein L32 -0.0410322
RPL9 ribosomal protein L9 -0.0404205
RPS16 ribosomal protein S16 -0.0381393
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0374547
RPL19 ribosomal protein L19 -0.0366178
RPS25 ribosomal protein S25 -0.0348272
RPL7A ribosomal protein L7a -0.0345747
ACTG1 actin gamma 1 -0.033845
RPLP0 ribosomal protein, large, P0 -0.0331525
RPL28 ribosomal protein L28 -0.0323611
RPL36 ribosomal protein L36 -0.0317246
GNAS GNAS complex locus -0.0316248
RPL27 ribosomal protein L27 -0.0312531
S100A9 S100 calcium binding protein A9 -0.0310423
RPL10A ribosomal protein L10a -0.0301525
EIF1 eukaryotic translation initiation factor 1 -0.0296895
PTMA prothymosin, alpha -0.0293405
ISG15 ISG15 ubiquitin-like modifier -0.0291775
RPS15 ribosomal protein S15 -0.02906
RPL37 ribosomal protein L37 -0.0286028
RACK1 receptor for activated C kinase 1 -0.0285796
RRBP1 ribosome binding protein 1 -0.0285046
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0281149
RPL8 ribosomal protein L8 -0.027754
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0274739
RPL30 ribosomal protein L30 -0.0273678
AMBP alpha-1-microglobulin/bikunin precursor -0.0269133
IER3 immediate early response 3 -0.0266954
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.026483
EGR1 early growth response 1 -0.0264538
APOC1 apolipoprotein C-I -0.026201
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0261974
RPL7 ribosomal protein L7 -0.0260547
RPS17 ribosomal protein S17 -0.0259843
B2M beta-2-microglobulin -0.0255131
CCL20 chemokine (C-C motif) ligand 20 -0.0247058
ATP5F1E ATP synthase F1 subunit epsilon -0.0246468
RPS5 ribosomal protein S5 -0.0246192
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0237539
RPL35 ribosomal protein L35 -0.0236735
RPS20 ribosomal protein S20 -0.0232752
LOC112694756 uncharaterized LOC112694756 -0.0229642
NAP1L1 nucleosome assembly protein 1-like 1 -0.0227448
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0226861
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0222018
LCN2 lipocalin 2 -0.0221411
RPL36A ribosomal protein L36a -0.0219159
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0213784
APOA1 apolipoprotein A-I -0.0212619
RPL18 ribosomal protein L18 -0.0212033
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0209384
S100P S100 calcium binding protein P -0.0208589
EIF5B eukaryotic translation initiation factor 5B -0.0208235
TM4SF1 transmembrane 4 L six family member 1 -0.0201736
FOXP1 forkhead box P1 -0.0199211
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0195604
IFITM1 interferon induced transmembrane protein 1 -0.0194349
RPS27 ribosomal protein S27 -0.0193139
H3-3B H3.3 histone B -0.0190227
BCL2L1 BCL2-like 1 -0.0189557
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0184672
RPS11 ribosomal protein S11 -0.0184508
ATF4 activating transcription factor 4 -0.017925