Cinacalcet_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.161805
TXNRD1 thioredoxin reductase 1 0.0726851
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0721896
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.06719
MCL1 myeloid cell leukemia 1 0.0599521
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0496502
CES1 carboxylesterase 1 0.0471273
SLTM SAFB-like, transcription modulator 0.042263
MKI67 marker of proliferation Ki-67 0.042198
DOCK5 dedicator of cytokinesis 5 0.0392098
TES testin LIM domain protein 0.0355843
ELL2 elongation factor, RNA polymerase II, 2 0.0343401
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0330052
USP34 ubiquitin specific peptidase 34 0.0329494
GSK3B glycogen synthase kinase 3 beta 0.0328955
CEMIP cell migration inducing protein, hyaluronan binding 0.0327269
MCTP1 multiple C2 domains, transmembrane 1 0.0318093
TBC1D22A TBC1 domain family, member 22A 0.0309935
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0300122
DSCAM Down syndrome cell adhesion molecule 0.029162
LRP1B low density lipoprotein receptor-related protein 1B 0.0291534
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0274877
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0272167
VMP1 vacuole membrane protein 1 0.026743
SPAG9 sperm associated antigen 9 0.026292
ZBTB20 zinc finger and BTB domain containing 20 0.0252428
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.024628
MYO1E myosin IE 0.0245908
AGO2 argonaute RISC catalytic component 2 0.0244087
PCBP2 poly(rC) binding protein 2 0.0238814
CCNL1 cyclin L1 0.0237914
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0233294
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0232913
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0230441
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.02244
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0223385
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0220273
PATJ PATJ crumbs cell polarity complex component 0.0219232
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0213966
ZC3H11A zinc finger CCCH-type containing 11A 0.0211844
MGST1 microsomal glutathione S-transferase 1 0.0211064
LRP12 low density lipoprotein receptor-related protein 12 0.0210604
SAMD4A sterile alpha motif domain containing 4A 0.0207193
JMJD1C jumonji domain containing 1C 0.020619
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0204451
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0204251
NPC1 Niemann-Pick disease, type C1 0.0202781
LAMC2 laminin, gamma 2 0.020228
RTN4 reticulon 4 0.0201019
GPATCH2L G patch domain containing 2-like 0.0200221
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0196394
PDLIM5 PDZ and LIM domain 5 0.019523
CAMTA1 calmodulin binding transcription activator 1 0.0191795
ZNF638 zinc finger protein 638 0.0191541
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0189862
TRIP12 thyroid hormone receptor interactor 12 0.0186331
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0185637
MYH9 myosin, heavy chain 9, non-muscle 0.0184204
PDE4D phosphodiesterase 4D, cAMP-specific 0.0183978
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0183889
VCL vinculin 0.0183788
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0182483
PTEN phosphatase and tensin homolog 0.0177309
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0175883
ARL5B ADP-ribosylation factor-like 5B 0.0175318
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0174274
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0172894
SFPQ splicing factor proline/glutamine-rich 0.0172096
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0168119
ZNF148 zinc finger protein 148 0.0166337
AKAP13 A kinase (PRKA) anchor protein 13 0.0165073
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0164423
SYAP1 synapse associated protein 1 0.0163302
EFNA5 ephrin-A5 0.0163195
SIK3 SIK family kinase 3 0.0162011
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0160424
MSN moesin 0.0160042
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0159781
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0159737
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0157311
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.015466
ADAM9 ADAM metallopeptidase domain 9 0.0153895
CLTC clathrin, heavy chain (Hc) 0.01536
ADAM17 ADAM metallopeptidase domain 17 0.0151137
TJP1 tight junction protein 1 0.0150082
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0149579
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0149517
SCFD1 sec1 family domain containing 1 0.0148804
MAP7 microtubule-associated protein 7 0.0148319
KDM5A lysine (K)-specific demethylase 5A 0.0145468
EXT1 exostosin glycosyltransferase 1 0.0144902
OCLN occludin 0.0143914
FAT1 FAT atypical cadherin 1 0.014295
SOD2 superoxide dismutase 2, mitochondrial 0.0142615
MYO1B myosin IB 0.0142408
CARD16 caspase recruitment domain family, member 16 0.0140402
COPA coatomer protein complex, subunit alpha 0.0139486
KDM2A lysine (K)-specific demethylase 2A 0.0138564
ADAR adenosine deaminase, RNA-specific 0.013833
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0137816

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0811029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0681046
PTMA prothymosin, alpha -0.0608846
TMSB10 thymosin beta 10 -0.0561258
ASPH aspartate beta-hydroxylase -0.0528188
TPT1 tumor protein, translationally-controlled 1 -0.0494773
LMO7 LIM domain 7 -0.0394995
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0374124
CAV1 caveolin 1, caveolae protein, 22kDa -0.0360583
ACTG1 actin gamma 1 -0.0326202
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0314737
RPS3 ribosomal protein S3 -0.0306798
RPLP1 ribosomal protein, large, P1 -0.030051
SEC61G Sec61 gamma subunit -0.0300497
FAM13A family with sequence similarity 13, member A -0.0296658
NDRG1 N-myc downstream regulated 1 -0.0295686
S100A10 S100 calcium binding protein A10 -0.0286913
FTL ferritin, light polypeptide -0.0277516
RPL35A ribosomal protein L35a -0.0264518
RPS27A ribosomal protein S27a -0.0261623
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0253536
DDIT4 DNA-damage-inducible transcript 4 -0.0249458
ZMYND8 zinc finger, MYND-type containing 8 -0.0245338
BZW1 basic leucine zipper and W2 domains 1 -0.0244896
LOC112694756 uncharaterized LOC112694756 -0.0239071
WSB1 WD repeat and SOCS box containing 1 -0.0239006
KDM3A lysine (K)-specific demethylase 3A -0.0236861
H1-0 H1.0 linker histone -0.0233813
LDHA lactate dehydrogenase A -0.0228529
ANKRD37 ankyrin repeat domain 37 -0.0221119
IER3 immediate early response 3 -0.0214029
RPL37A ribosomal protein L37a -0.0212287
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0210695
THSD4 thrombospondin, type I, domain containing 4 -0.0209944
STC1 stanniocalcin 1 -0.0207533
ENO1 enolase 1, (alpha) -0.0200683
MT2A metallothionein 2A -0.0199482
AHNAK2 AHNAK nucleoprotein 2 -0.0197269
AHNAK AHNAK nucleoprotein -0.0196648
AKAP12 A kinase (PRKA) anchor protein 12 -0.0194304
GNAS GNAS complex locus -0.0193892
RPL34 ribosomal protein L34 -0.0186974
BRWD3 bromodomain and WD repeat domain containing 3 -0.0183149
SMAD3 SMAD family member 3 -0.0174793
LAMB3 laminin, beta 3 -0.0173033
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0170561
S100A6 S100 calcium binding protein A6 -0.0170468
PTPRM protein tyrosine phosphatase, receptor type, M -0.0168031
TRIM56 tripartite motif containing 56 -0.0167915
HILPDA hypoxia inducible lipid droplet-associated -0.0165716
RPL12 ribosomal protein L12 -0.0165368
HLA-B major histocompatibility complex, class I, B -0.0165363
ANXA2 annexin A2 -0.0164988
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0164396
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0162803
RPL30 ribosomal protein L30 -0.0162106
RPS8 ribosomal protein S8 -0.0160825
BTG1 B-cell translocation gene 1, anti-proliferative -0.0157363
RPS12 ribosomal protein S12 -0.0156443
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0153295
GM2A GM2 ganglioside activator -0.0152602
PDE8A phosphodiesterase 8A -0.0150068
CSTB cystatin B (stefin B) -0.0149936
CCND1 cyclin D1 -0.0147961
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0146864
SQSTM1 sequestosome 1 -0.0146276
TTC3 tetratricopeptide repeat domain 3 -0.0144306
PGK1 phosphoglycerate kinase 1 -0.014153
IGFBP5 insulin-like growth factor binding protein 5 -0.0136618
KPNB1 karyopherin (importin) beta 1 -0.0136524
RPL11 ribosomal protein L11 -0.0136057
ADM adrenomedullin -0.0131915
C15ORF48 chromosome 15 open reading frame 48 -0.0131904
MXI1 MAX interactor 1, dimerization protein -0.0131758
NCOA7 nuclear receptor coactivator 7 -0.0127946
RPL26 ribosomal protein L26 -0.0125789
RPS29 ribosomal protein S29 -0.0125508
NAP1L1 nucleosome assembly protein 1-like 1 -0.0125055
RPL37 ribosomal protein L37 -0.0122457
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0122452
APP amyloid beta (A4) precursor protein -0.0122427
EPCAM epithelial cell adhesion molecule -0.012227
RPS2 ribosomal protein S2 -0.0120809
CIB1 calcium and integrin binding 1 (calmyrin) -0.0120647
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0119335
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0119064
USP3 ubiquitin specific peptidase 3 -0.0118964
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0117744
RACK1 receptor for activated C kinase 1 -0.0117169
EMP1 epithelial membrane protein 1 -0.0114943
SP100 SP100 nuclear antigen -0.0113961
DSG2 desmoglein 2 -0.0112948
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0112941
RPL36 ribosomal protein L36 -0.0112883
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0112328
RAI14 retinoic acid induced 14 -0.0111463
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0109268
RPS19 ribosomal protein S19 -0.0109082
JUN jun proto-oncogene -0.0108097
RPS6 ribosomal protein S6 -0.0107719