Cinacalcet_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KDM2A lysine (K)-specific demethylase 2A 0.102117
NAMPT nicotinamide phosphoribosyltransferase 0.096915
FNDC3B fibronectin type III domain containing 3B 0.0958678
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0790773
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0784851
GOLGA4 golgin A4 0.0720211
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0679067
DSCAM Down syndrome cell adhesion molecule 0.0483037
TRIO trio Rho guanine nucleotide exchange factor 0.0468682
USP34 ubiquitin specific peptidase 34 0.0436701
NPC1 Niemann-Pick disease, type C1 0.0431473
SMAD3 SMAD family member 3 0.0413766
ATP13A3 ATPase type 13A3 0.0411919
CD44 CD44 molecule (Indian blood group) 0.0411219
AKAP9 A kinase (PRKA) anchor protein 9 0.039834
ZEB2 zinc finger E-box binding homeobox 2 0.0391863
KMT2C lysine (K)-specific methyltransferase 2C 0.0381521
PELI1 pellino E3 ubiquitin protein ligase 1 0.0380102
SETD5 SET domain containing 5 0.0360288
OGA O-GlcNAcase 0.0359082
OSMR oncostatin M receptor 0.0338573
CTNND1 catenin (cadherin-associated protein), delta 1 0.0338474
ITCH itchy E3 ubiquitin protein ligase 0.0335351
FBXL13 F-box and leucine-rich repeat protein 13 0.0334357
RICTOR RPTOR independent companion of MTOR, complex 2 0.0329658
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0328079
DOCK5 dedicator of cytokinesis 5 0.0327116
NAV2 neuron navigator 2 0.0320836
RB1CC1 RB1-inducible coiled-coil 1 0.0320601
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0319831
UBA6 ubiquitin-like modifier activating enzyme 6 0.0319359
VMP1 vacuole membrane protein 1 0.0304303
COG5 component of oligomeric golgi complex 5 0.0303024
SIK3 SIK family kinase 3 0.030282
JMJD1C jumonji domain containing 1C 0.0297358
NBAS neuroblastoma amplified sequence 0.0297136
SEC23A Sec23 homolog A (S. cerevisiae) 0.0292538
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0290043
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0284995
NGLY1 N-glycanase 1 0.0282784
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0280898
ELL2 elongation factor, RNA polymerase II, 2 0.0272494
HELZ helicase with zinc finger 0.0271871
SRP54 signal recognition particle 54kDa 0.0267224
AHR aryl hydrocarbon receptor 0.0265534
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0263016
UBE2H ubiquitin-conjugating enzyme E2H 0.0259124
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0255611
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.025547
LRRC49 leucine rich repeat containing 49 0.0254387
ADD3 adducin 3 (gamma) 0.0253111
ANKRD17 ankyrin repeat domain 17 0.0252837
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.025243
PRELID2 PRELI domain containing 2 0.0250728
RUNX1 runt-related transcription factor 1 0.0250321
METTL15 methyltransferase like 15 0.0245944
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0245078
SBF2 SET binding factor 2 0.0244443
KYNU kynureninase 0.0243419
SOD2 superoxide dismutase 2, mitochondrial 0.0241728
ARRDC3 arrestin domain containing 3 0.0239673
RAB27B RAB27B, member RAS oncogene family 0.0238735
USP47 ubiquitin specific peptidase 47 0.0238344
ZFC3H1 zinc finger, C3H1-type containing 0.023769
RERE arginine-glutamic acid dipeptide (RE) repeats 0.023736
MARCHF6 membrane associated ring-CH-type finger 6 0.0235695
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0233052
SCFD1 sec1 family domain containing 1 0.0232001
COPA coatomer protein complex, subunit alpha 0.0229355
ELP2 elongator acetyltransferase complex subunit 2 0.0228179
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0228086
BIRC3 baculoviral IAP repeat containing 3 0.0227392
UGCG UDP-glucose ceramide glucosyltransferase 0.0226539
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0225272
FAM13A family with sequence similarity 13, member A 0.0224946
MYO1E myosin IE 0.0223956
STRN3 striatin, calmodulin binding protein 3 0.0223573
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0222569
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0220923
YEATS2 YEATS domain containing 2 0.02197
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0219621
CD109 CD109 molecule 0.0217937
SMAD4 SMAD family member 4 0.0217157
RUNX2 runt-related transcription factor 2 0.0215303
EGFR epidermal growth factor receptor 0.0213126
YME1L1 YME1-like 1 ATPase 0.021278
ZNF638 zinc finger protein 638 0.0210196
TBC1D15 TBC1 domain family, member 15 0.0209688
ZCCHC7 zinc finger, CCHC domain containing 7 0.0209187
CDCP1 CUB domain containing protein 1 0.0207459
FAM3C family with sequence similarity 3, member C 0.0205022
SPRED1 sprouty-related, EVH1 domain containing 1 0.0204591
SKAP2 src kinase associated phosphoprotein 2 0.0203032
TTC3 tetratricopeptide repeat domain 3 0.020291
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0202896
MON2 MON2 homolog (S. cerevisiae) 0.0201586
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0200996
CA12 carbonic anhydrase XII 0.0200452
PABPC1 poly(A) binding protein, cytoplasmic 1 0.020003
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0198632

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.150512
VIM vimentin -0.116303
FN1 fibronectin 1 -0.111335
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.102333
PTMA prothymosin, alpha -0.09694
HMGA2 high mobility group AT-hook 2 -0.0820624
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0778027
CDH13 cadherin 13 -0.0761918
FTL ferritin, light polypeptide -0.0734256
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0700146
NRG1 neuregulin 1 -0.0604891
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0572572
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0559994
MT2A metallothionein 2A -0.0545571
DPYD dihydropyrimidine dehydrogenase -0.0537896
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0523037
RPLP1 ribosomal protein, large, P1 -0.0497945
RPL35A ribosomal protein L35a -0.0474295
MAML3 mastermind-like 3 (Drosophila) -0.0448812
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0447397
TFPI2 tissue factor pathway inhibitor 2 -0.0442241
PDE4D phosphodiesterase 4D, cAMP-specific -0.0429417
S100A6 S100 calcium binding protein A6 -0.0428283
RPS19 ribosomal protein S19 -0.042598
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0419326
IER3 immediate early response 3 -0.0414874
ASPH aspartate beta-hydroxylase -0.0412593
FAM20C family with sequence similarity 20, member C -0.0412268
MTSS1 metastasis suppressor 1 -0.0403865
EGR1 early growth response 1 -0.0402862
PSD3 pleckstrin and Sec7 domain containing 3 -0.0387534
RPL34 ribosomal protein L34 -0.0386106
RPS6 ribosomal protein S6 -0.0368213
RPS8 ribosomal protein S8 -0.036045
NAP1L1 nucleosome assembly protein 1-like 1 -0.0360435
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0344893
AHNAK AHNAK nucleoprotein -0.0344628
TMSB4X thymosin beta 4, X-linked -0.0343076
SDK1 sidekick cell adhesion molecule 1 -0.0332944
S100A10 S100 calcium binding protein A10 -0.0332654
RPS12 ribosomal protein S12 -0.0329927
LOX lysyl oxidase -0.0328752
TPT1 tumor protein, translationally-controlled 1 -0.0326958
AADAC arylacetamide deacetylase -0.0325431
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0324301
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0323313
IFI44L interferon-induced protein 44-like -0.0319389
NTN4 netrin 4 -0.0317997
RPS21 ribosomal protein S21 -0.0316074
SP100 SP100 nuclear antigen -0.0314377
TGFB1 transforming growth factor, beta 1 -0.0313471
WSB1 WD repeat and SOCS box containing 1 -0.0307621
MACF1 microtubule-actin crosslinking factor 1 -0.0306294
GLCCI1 glucocorticoid induced 1 -0.0306259
RPL23 ribosomal protein L23 -0.0301841
RPL31 ribosomal protein L31 -0.0298875
RPL37A ribosomal protein L37a -0.0298095
SAMD9 sterile alpha motif domain containing 9 -0.0296135
CLMP CXADR-like membrane protein -0.0287053
ANTXR2 anthrax toxin receptor 2 -0.0284031
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0283083
CDK14 cyclin-dependent kinase 14 -0.0274551
RPL13A ribosomal protein L13a -0.0270242
LRMDA leucine rich melanocyte differentiation associated -0.0270068
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0267092
RPL36 ribosomal protein L36 -0.0265145
GNAS GNAS complex locus -0.0265097
RPS3 ribosomal protein S3 -0.026461
DDIT3 DNA-damage-inducible transcript 3 -0.0261936
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0261705
RPLP2 ribosomal protein, large, P2 -0.0260988
COL7A1 collagen, type VII, alpha 1 -0.0257624
TM4SF1 transmembrane 4 L six family member 1 -0.0252226
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0251959
SYT1 synaptotagmin I -0.0251077
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0250804
NPAS2 neuronal PAS domain protein 2 -0.0249798
FBN1 fibrillin 1 -0.0243639
STC1 stanniocalcin 1 -0.0243055
RPS24 ribosomal protein S24 -0.024057
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0238732
EFCAB13 EF-hand calcium binding domain 13 -0.0237889
GLIS3 GLIS family zinc finger 3 -0.0237024
NAV1 neuron navigator 1 -0.0236434
DST dystonin -0.0236029
JUN jun proto-oncogene -0.0233439
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0229482
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0229154
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0228155
RIGI RNA sensor RIG-I -0.0225667
YBX1 Y box binding protein 1 -0.0224617
LOC102724023 ES1 protein homolog, mitochondrial -0.0222347
LMNA lamin A/C -0.0222231
ANXA2 annexin A2 -0.0220882
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.021741
PTK2 protein tyrosine kinase 2 -0.0216695
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0216056
MSRB3 methionine sulfoxide reductase B3 -0.0215953
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0213976
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0213406