Cinacalcet_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.0621237
ZFAND3 zinc finger, AN1-type domain 3 0.0472364
TXNRD1 thioredoxin reductase 1 0.0380927
DSCAM Down syndrome cell adhesion molecule 0.0346659
BIRC3 baculoviral IAP repeat containing 3 0.0302912
WWOX WW domain containing oxidoreductase 0.0253967
ANKRD11 ankyrin repeat domain 11 0.0252357
VMP1 vacuole membrane protein 1 0.0223413
DENND4A DENN/MADD domain containing 4A 0.0217256
WDR43 WD repeat domain 43 0.0217056
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0212544
BIRC6 baculoviral IAP repeat containing 6 0.0189503
USP3 ubiquitin specific peptidase 3 0.0188649
TM4SF1 transmembrane 4 L six family member 1 0.0185999
GLG1 golgi glycoprotein 1 0.018447
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0183567
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0178669
CCNL1 cyclin L1 0.017485
RASAL2 RAS protein activator like 2 0.0167547
MAPK8 mitogen-activated protein kinase 8 0.0163468
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0163113
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0158346
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0157142
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0153486
MATR3 matrin 3 0.0153447
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0151512
FAM168A family with sequence similarity 168, member A 0.0149215
RBM39 RNA binding motif protein 39 0.0148239
WIPF2 WAS/WASL interacting protein family, member 2 0.014808
RRM2 ribonucleotide reductase M2 0.0146548
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0145689
FBXL20 F-box and leucine-rich repeat protein 20 0.0145333
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0141103
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0137838
NAMPT nicotinamide phosphoribosyltransferase 0.0134823
RTN4 reticulon 4 0.0134734
ZNF207 zinc finger protein 207 0.0134727
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0134208
MIS18BP1 MIS18 binding protein 1 0.0134054
RHEB Ras homolog enriched in brain 0.0133703
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0132751
MRTFA myocardin related transcription factor A 0.0131869
NUP58 nucleoporin 58 0.0131485
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.013012
NFE2L2 nuclear factor, erythroid 2-like 2 0.0127931
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0125943
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0124761
MORF4L1 mortality factor 4 like 1 0.0124745
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0124628
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0124209
LONP2 lon peptidase 2, peroxisomal 0.0121907
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.012175
CCL5 chemokine (C-C motif) ligand 5 0.0120916
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.012076
ARL5B ADP-ribosylation factor-like 5B 0.0119518
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0118583
CYRIB CYFIP related Rac1 interactor B 0.011797
TNPO1 transportin 1 0.0117692
CLTC clathrin, heavy chain (Hc) 0.0116593
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0115585
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0115543
SPAG9 sperm associated antigen 9 0.0115027
SIN3A SIN3 transcription regulator family member A 0.0114689
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0113517
SFPQ splicing factor proline/glutamine-rich 0.0112812
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0110953
CREBBP CREB binding protein 0.0110529
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0110515
NEK7 NIMA-related kinase 7 0.0110196
KDM3A lysine (K)-specific demethylase 3A 0.0110149
KDM6A lysine (K)-specific demethylase 6A 0.0109375
YTHDC1 YTH domain containing 1 0.0108489
FAM168B family with sequence similarity 168, member B 0.0108285
NCEH1 neutral cholesterol ester hydrolase 1 0.0108276
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0108247
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.010656
SMAD3 SMAD family member 3 0.0106405
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0106298
ADAM17 ADAM metallopeptidase domain 17 0.0106087
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0104606
WWC2 WW and C2 domain containing 2 0.0104001
AVL9 AVL9 homolog (S. cerevisiase) 0.0103522
RAB10 RAB10, member RAS oncogene family 0.0102572
CTNNBL1 catenin, beta like 1 0.0102392
CAMKMT calmodulin-lysine N-methyltransferase 0.0102364
SRSF5 serine/arginine-rich splicing factor 5 0.0101934
CYTH1 cytohesin 1 0.0101904
NOP58 NOP58 ribonucleoprotein 0.0101856
SRBD1 S1 RNA binding domain 1 0.0101844
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0100606
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0100525
RFWD3 ring finger and WD repeat domain 3 0.0100487
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.00997437
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.00997335
MACF1 microtubule-actin crosslinking factor 1 0.00992171
GLS2 glutaminase 2 (liver, mitochondrial) 0.00990479
NPC1 Niemann-Pick disease, type C1 0.00988568
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.00986355
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.00984474
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0098271

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.116495
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0991844
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0796415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0585061
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0568371
VIM vimentin -0.055537
FTL ferritin, light polypeptide -0.0496778
AKAP12 A kinase (PRKA) anchor protein 12 -0.0465859
FTH1 ferritin, heavy polypeptide 1 -0.0453623
THSD4 thrombospondin, type I, domain containing 4 -0.0453194
S100A6 S100 calcium binding protein A6 -0.04419
PTMA prothymosin, alpha -0.04286
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.039997
MT2A metallothionein 2A -0.039378
PKM pyruvate kinase, muscle -0.0370468
EGR1 early growth response 1 -0.0340473
POTEF POTE ankyrin domain family, member F -0.0329772
ACTG1 actin gamma 1 -0.0324274
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0323452
TFPI2 tissue factor pathway inhibitor 2 -0.0316315
RPS8 ribosomal protein S8 -0.0313563
PDE4D phosphodiesterase 4D, cAMP-specific -0.0282208
RPL19 ribosomal protein L19 -0.0278174
IGFBP3 insulin-like growth factor binding protein 3 -0.0273277
BASP1 brain abundant, membrane attached signal protein 1 -0.0273224
PYGL phosphorylase, glycogen, liver -0.0267179
RPL35A ribosomal protein L35a -0.0265004
PFN1 profilin 1 -0.0261459
RPL23 ribosomal protein L23 -0.0260288
LOC102724023 ES1 protein homolog, mitochondrial -0.0258568
RPL37A ribosomal protein L37a -0.0254075
LDHA lactate dehydrogenase A -0.024892
YBX1 Y box binding protein 1 -0.0241484
RPS6 ribosomal protein S6 -0.0236354
ASPH aspartate beta-hydroxylase -0.0235994
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0231865
RPL8 ribosomal protein L8 -0.0230119
CALR calreticulin -0.02296
RPS2 ribosomal protein S2 -0.0228534
STC1 stanniocalcin 1 -0.0227128
TPM3 tropomyosin 3 -0.0217585
ENO1 enolase 1, (alpha) -0.021745
IGF2 insulin-like growth factor 2 -0.0214105
FLNB filamin B, beta -0.0214004
RPS3 ribosomal protein S3 -0.021348
RPS27A ribosomal protein S27a -0.0212692
TAGLN2 transgelin 2 -0.0204631
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0200672
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0199575
TPI1 triosephosphate isomerase 1 -0.019629
RACK1 receptor for activated C kinase 1 -0.019323
ANXA2 annexin A2 -0.018868
DOCK4 dedicator of cytokinesis 4 -0.0187471
CAVIN1 caveolae associated protein 1 -0.0185339
RPL36 ribosomal protein L36 -0.0184254
RPS12 ribosomal protein S12 -0.0183954
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0182725
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0179015
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0177134
AHNAK AHNAK nucleoprotein -0.017698
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0175949
S100A10 S100 calcium binding protein A10 -0.0174878
SLC38A2 solute carrier family 38, member 2 -0.0170292
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0168278
IGFBP4 insulin-like growth factor binding protein 4 -0.0167359
PLS3 plastin 3 -0.0166847
RPLP1 ribosomal protein, large, P1 -0.0166278
LOC112694756 uncharaterized LOC112694756 -0.0164945
JUN jun proto-oncogene -0.0161278
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0158866
ELL2 elongation factor, RNA polymerase II, 2 -0.0153865
RPL37 ribosomal protein L37 -0.0152119
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0150312
TPM4 tropomyosin 4 -0.0150162
CUX1 cut-like homeobox 1 -0.0148957
ANXA1 annexin A1 -0.0148897
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -0.0148506
GNAS GNAS complex locus -0.0144241
RHOA ras homolog family member A -0.0140128
FMNL2 formin-like 2 -0.0139118
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0137219
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0135884
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0135474
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0134791
ARHGAP26 Rho GTPase activating protein 26 -0.0133803
PRR16 proline rich 16 -0.0130731
MAML3 mastermind-like 3 (Drosophila) -0.0129629
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0129154
RBM8A RNA binding motif protein 8A -0.0127953
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0127671
GLIS3 GLIS family zinc finger 3 -0.0123928
TMSB4X thymosin beta 4, X-linked -0.0123521
SLC35F3 solute carrier family 35, member F3 -0.0122652
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0122587
RPS27 ribosomal protein S27 -0.0121352
RPL13A ribosomal protein L13a -0.0120665
RBM25 RNA binding motif protein 25 -0.0118718
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0117327
PM20D1 peptidase M20 domain containing 1 -0.0116321
CMIP c-Maf inducing protein -0.0116198