Cinacalcet_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.159887
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.121246
IFIH1 interferon induced with helicase C domain 1 0.111128
DSCAM Down syndrome cell adhesion molecule 0.105806
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.100911
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.099198
NDRG1 N-myc downstream regulated 1 0.0989384
SPAG9 sperm associated antigen 9 0.0916171
VIM vimentin 0.0880034
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0860962
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0858945
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0820151
ENO1 enolase 1, (alpha) 0.0741485
KDM6A lysine (K)-specific demethylase 6A 0.0682711
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.067904
ANXA2 annexin A2 0.0675962
ABLIM1 actin binding LIM protein 1 0.0657077
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.063087
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0627124
GRB10 growth factor receptor-bound protein 10 0.061854
HOOK2 hook microtubule-tethering protein 2 0.0616504
KDM5B lysine (K)-specific demethylase 5B 0.0612629
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0598696
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0582863
RAB8B RAB8B, member RAS oncogene family 0.05797
PCBP2 poly(rC) binding protein 2 0.0574656
B2M beta-2-microglobulin 0.0559459
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0557083
ZNF292 zinc finger protein 292 0.0539816
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0536392
PTMA prothymosin, alpha 0.0529999
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0529186
FAM13A family with sequence similarity 13, member A 0.0518224
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0505608
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0485175
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0483528
RNF149 ring finger protein 149 0.0475848
MT2A metallothionein 2A 0.0464836
TSC22D2 TSC22 domain family, member 2 0.0459033
GOLGA4 golgin A4 0.0445644
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0436998
DTNA dystrobrevin, alpha 0.0425419
BBX bobby sox homolog (Drosophila) 0.0419539
BIRC6 baculoviral IAP repeat containing 6 0.0413834
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0410995
PDE10A phosphodiesterase 10A 0.0409904
KDM3A lysine (K)-specific demethylase 3A 0.040457
RTN4 reticulon 4 0.0391578
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 0.0389605
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0382378
FTL ferritin, light polypeptide 0.0379952
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0379918
PGK1 phosphoglycerate kinase 1 0.0375659
TMEM165 transmembrane protein 165 0.037429
EEF2 eukaryotic translation elongation factor 2 0.0366087
NKD1 naked cuticle homolog 1 (Drosophila) 0.036471
AFF1 AF4/FMR2 family, member 1 0.036466
RICTOR RPTOR independent companion of MTOR, complex 2 0.0360268
BACE2 beta-site APP-cleaving enzyme 2 0.0357339
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0356018
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.035262
FN1 fibronectin 1 0.0350316
TMSB10 thymosin beta 10 0.0349919
TMSB4X thymosin beta 4, X-linked 0.034486
COPA coatomer protein complex, subunit alpha 0.0337259
TPD52 tumor protein D52 0.0337139
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0336944
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0335738
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0325211
FAT1 FAT atypical cadherin 1 0.0324965
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0324223
RAB7A RAB7A, member RAS oncogene family 0.0322645
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0319746
KMT2E lysine (K)-specific methyltransferase 2E 0.0319153
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0316333
GPBP1 GC-rich promoter binding protein 1 0.0313059
TNIP1 TNFAIP3 interacting protein 1 0.0312503
XPO1 exportin 1 0.0310987
SLMAP sarcolemma associated protein 0.0309231
GPC6 glypican 6 0.0304908
TNS3 tensin 3 0.0304898
SOS1 son of sevenless homolog 1 (Drosophila) 0.0304021
CSNK1A1 casein kinase 1, alpha 1 0.0303885
ADAM17 ADAM metallopeptidase domain 17 0.0299857
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0294469
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0293489
MARCHF7 membrane associated ring-CH-type finger 7 0.0293156
RPS8 ribosomal protein S8 0.0291685
NCKAP1 NCK-associated protein 1 0.0290283
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0287636
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0287393
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0284918
KMT2C lysine (K)-specific methyltransferase 2C 0.0283882
SET SET nuclear proto-oncogene 0.0281842
MYO5B myosin VB 0.0281342
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0275712
PNISR PNN-interacting serine/arginine-rich protein 0.0275631
RPL5 ribosomal protein L5 0.0275177
OGA O-GlcNAcase 0.0267713
LDHA lactate dehydrogenase A 0.0266038

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.217454
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.189378
SAMD4A sterile alpha motif domain containing 4A -0.161667
CEMIP cell migration inducing protein, hyaluronan binding -0.159493
COL6A3 collagen, type VI, alpha 3 -0.109263
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.105054
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0983529
ADGRB3 adhesion G protein-coupled receptor B3 -0.0970934
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0956571
LIMCH1 LIM and calponin homology domains 1 -0.0951835
AHNAK AHNAK nucleoprotein -0.0950205
MMP1 matrix metallopeptidase 1 -0.0884393
RBM47 RNA binding motif protein 47 -0.0857513
SHB Src homology 2 domain containing adaptor protein B -0.0822813
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0768876
PLAUR plasminogen activator, urokinase receptor -0.0749827
ABI3BP ABI family, member 3 (NESH) binding protein -0.0746369
MAML3 mastermind-like 3 (Drosophila) -0.0737819
MAST4 microtubule associated serine/threonine kinase family member 4 -0.073332
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0720886
DOCK5 dedicator of cytokinesis 5 -0.0701679
FRMD5 FERM domain containing 5 -0.0699878
ZSWIM6 zinc finger, SWIM-type containing 6 -0.065783
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0656624
NABP1 nucleic acid binding protein 1 -0.0643925
ARHGAP32 Rho GTPase activating protein 32 -0.0635127
LAMC2 laminin, gamma 2 -0.0632501
MAML2 mastermind-like 2 (Drosophila) -0.0631377
INTS6 integrator complex subunit 6 -0.0630442
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0629908
SACK1A scaffolding CK1 anchoring protein A -0.062243
SEPTIN10 septin 10 -0.0571159
DENND4A DENN/MADD domain containing 4A -0.0570369
PTPRM protein tyrosine phosphatase, receptor type, M -0.0569703
WARS1 tryptophanyl-tRNA synthetase 1 -0.0567956
HOMER1 homer scaffolding protein 1 -0.0562034
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0554476
GLS2 glutaminase 2 (liver, mitochondrial) -0.0551399
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0533993
HPCAL1 hippocalcin-like 1 -0.0527418
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0523533
FER fer (fps/fes related) tyrosine kinase -0.0521388
MUC16 mucin 16, cell surface associated -0.0507249
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0495252
MAP4 microtubule-associated protein 4 -0.0487533
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0477582
PRKCA protein kinase C, alpha -0.0470457
CUX1 cut-like homeobox 1 -0.0462086
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.046059
ANTXR2 anthrax toxin receptor 2 -0.0448549
ATP13A3 ATPase type 13A3 -0.0445132
MYO1E myosin IE -0.0440659
NALF1 NALCN channel auxiliary factor 1 -0.0424451
OSMR oncostatin M receptor -0.0420727
ATOSA atos homolog A -0.0419734
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0417357
CMIP c-Maf inducing protein -0.0416447
NUP98 nucleoporin 98kDa -0.04145
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0406394
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0405799
PATJ PATJ crumbs cell polarity complex component -0.0400223
TRIO trio Rho guanine nucleotide exchange factor -0.0398877
ZNF638 zinc finger protein 638 -0.0393778
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0385528
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0383526
PARD3 par-3 family cell polarity regulator -0.037823
ZFAND3 zinc finger, AN1-type domain 3 -0.0377457
MYO10 myosin X -0.0375101
SOD2 superoxide dismutase 2, mitochondrial -0.0360204
NAMPT nicotinamide phosphoribosyltransferase -0.0359477
SDK1 sidekick cell adhesion molecule 1 -0.0358095
EFNA5 ephrin-A5 -0.0357635
WSB1 WD repeat and SOCS box containing 1 -0.0355465
DIAPH2 diaphanous-related formin 2 -0.0352261
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0341952
TM4SF1 transmembrane 4 L six family member 1 -0.0339441
LAMB3 laminin, beta 3 -0.0339411
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0339254
BRWD1 bromodomain and WD repeat domain containing 1 -0.0330768
CA12 carbonic anhydrase XII -0.0328257
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.0328242
RASA2 RAS p21 protein activator 2 -0.0325866
PKP4 plakophilin 4 -0.0324344
FTH1 ferritin, heavy polypeptide 1 -0.0323391
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0321129
LPP LIM domain containing preferred translocation partner in lipoma -0.0321004
MED13L mediator complex subunit 13-like -0.0319516
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0317722
FHIT fragile histidine triad -0.0311729
HLA-B major histocompatibility complex, class I, B -0.0308494
EGFR epidermal growth factor receptor -0.030495
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0302835
TAS2R14 taste receptor, type 2, member 14 -0.0300104
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0299911
ABHD17C abhydrolase domain containing 17C -0.0299547
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0294468
F3 coagulation factor III (thromboplastin, tissue factor) -0.0290475
METTL15 methyltransferase like 15 -0.0289514
AKAP12 A kinase (PRKA) anchor protein 12 -0.0287001
ZBTB20 zinc finger and BTB domain containing 20 -0.0282421