Cinacalcet_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cinacalcet_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.149599
MCL1 myeloid cell leukemia 1 0.0889871
EFNA5 ephrin-A5 0.0861871
GDA guanine deaminase 0.0700278
LIMCH1 LIM and calponin homology domains 1 0.059332
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0570652
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0566808
GRAMD1B GRAM domain containing 1B 0.052607
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0488832
TGFBI transforming growth factor, beta-induced, 68kDa 0.048707
SAMD4A sterile alpha motif domain containing 4A 0.0446981
STC1 stanniocalcin 1 0.0433251
FNDC3A fibronectin type III domain containing 3A 0.0429657
ELL2 elongation factor, RNA polymerase II, 2 0.0415359
PYGL phosphorylase, glycogen, liver 0.0409726
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0394659
ESYT2 extended synaptotagmin-like protein 2 0.0387066
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0386196
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0385012
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.038432
ERRFI1 ERBB receptor feedback inhibitor 1 0.0381127
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.037415
AVL9 AVL9 homolog (S. cerevisiase) 0.0366173
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0364951
COL4A6 collagen, type IV, alpha 6 0.0353717
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0344015
IGFBP3 insulin-like growth factor binding protein 3 0.0328712
ITPRID2 ITPR interacting domain containing 2 0.0325634
NPAS2 neuronal PAS domain protein 2 0.0322956
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0311183
DOCK4 dedicator of cytokinesis 4 0.0294492
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0288562
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.027491
ZEB2 zinc finger E-box binding homeobox 2 0.026637
CD44 CD44 molecule (Indian blood group) 0.0266102
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0263081
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0261453
NCAM1 neural cell adhesion molecule 1 0.025875
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0258115
MFF mitochondrial fission factor 0.0251373
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0244214
BMERB1 bMERB domain containing 1 0.0242911
NAMPT nicotinamide phosphoribosyltransferase 0.0236803
TFPI2 tissue factor pathway inhibitor 2 0.0232909
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.023037
PDLIM5 PDZ and LIM domain 5 0.0229592
DGKD diacylglycerol kinase, delta 130kDa 0.0225591
FLNB filamin B, beta 0.0221541
TGFBR1 transforming growth factor, beta receptor 1 0.0220655
IL1RAP interleukin 1 receptor accessory protein 0.021697
USP34 ubiquitin specific peptidase 34 0.0206145
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0201198
MYOF myoferlin 0.0197595
NBEAL1 neurobeachin-like 1 0.0193928
CD109 CD109 molecule 0.0192037
ARHGAP29 Rho GTPase activating protein 29 0.0190002
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0188596
STC2 stanniocalcin 2 0.0185456
BIRC6 baculoviral IAP repeat containing 6 0.0179758
ANKRD28 ankyrin repeat domain 28 0.0178589
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0178472
ZFC3H1 zinc finger, C3H1-type containing 0.0175147
NEK7 NIMA-related kinase 7 0.0173396
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0171088
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0171008
SDK1 sidekick cell adhesion molecule 1 0.017007
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0168786
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0167651
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0163796
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.016367
ATP13A3 ATPase type 13A3 0.0161471
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0161191
CARD16 caspase recruitment domain family, member 16 0.015999
NDRG1 N-myc downstream regulated 1 0.0159332
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0159292
AKAP13 A kinase (PRKA) anchor protein 13 0.0159242
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.015842
ARHGAP5 Rho GTPase activating protein 5 0.0158073
FNDC3B fibronectin type III domain containing 3B 0.0157915
CEP170 centrosomal protein 170kDa 0.0155679
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0154776
ABLIM1 actin binding LIM protein 1 0.0150606
ENAH enabled homolog (Drosophila) 0.014982
MSN moesin 0.0149455
NRCAM neuronal cell adhesion molecule 0.0148884
TPD52 tumor protein D52 0.0147156
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0147019
RTN4 reticulon 4 0.014688
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0144816
BMP6 bone morphogenetic protein 6 0.0143843
PFKP phosphofructokinase, platelet 0.0141962
NBAS neuroblastoma amplified sequence 0.0141283
PM20D1 peptidase M20 domain containing 1 0.0139723
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0136868
PTEN phosphatase and tensin homolog 0.0136465
COPA coatomer protein complex, subunit alpha 0.013505
NGLY1 N-glycanase 1 0.0134974
ARRDC3 arrestin domain containing 3 0.0134564
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0134456
DUSP4 dual specificity phosphatase 4 0.0131869

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.168263
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.139061
PTMA prothymosin, alpha -0.132594
TMSB10 thymosin beta 10 -0.117131
PDE10A phosphodiesterase 10A -0.110902
RPS6 ribosomal protein S6 -0.0965992
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0942723
COL5A2 collagen, type V, alpha 2 -0.0888624
FTL ferritin, light polypeptide -0.0883855
NALF1 NALCN channel auxiliary factor 1 -0.0837893
RPLP1 ribosomal protein, large, P1 -0.0793013
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0753242
RPL37A ribosomal protein L37a -0.0704791
TPT1 tumor protein, translationally-controlled 1 -0.0683068
RPS8 ribosomal protein S8 -0.0670024
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.065603
RPL12 ribosomal protein L12 -0.0650041
RPS12 ribosomal protein S12 -0.0638421
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0635823
SMYD3 SET and MYND domain containing 3 -0.0615567
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0612538
RPL26 ribosomal protein L26 -0.0609838
RPL35A ribosomal protein L35a -0.0607669
RPL23 ribosomal protein L23 -0.0602993
NAP1L1 nucleosome assembly protein 1-like 1 -0.0583144
RPS19 ribosomal protein S19 -0.0578981
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0573904
PRKN parkin RBR E3 ubiquitin protein ligase -0.0539234
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0535614
VIM vimentin -0.0495953
RPL13A ribosomal protein L13a -0.048519
RPS24 ribosomal protein S24 -0.0460026
RPL19 ribosomal protein L19 -0.0459736
LSAMP limbic system-associated membrane protein -0.0444439
RPL31 ribosomal protein L31 -0.044236
RPL34 ribosomal protein L34 -0.0436266
P3H2 prolyl 3-hydroxylase 2 -0.0432753
RPL9 ribosomal protein L9 -0.042659
RPS3 ribosomal protein S3 -0.0420459
RPL11 ribosomal protein L11 -0.0420053
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0396633
PSD3 pleckstrin and Sec7 domain containing 3 -0.0389758
RPL37 ribosomal protein L37 -0.0375317
RPS27A ribosomal protein S27a -0.0371878
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0369607
GNAS GNAS complex locus -0.0359661
RPL36 ribosomal protein L36 -0.0357095
CDH13 cadherin 13 -0.0353731
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0350777
ACTG1 actin gamma 1 -0.0346568
YBX1 Y box binding protein 1 -0.0327948
RPL35 ribosomal protein L35 -0.0326198
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0319324
RPS27 ribosomal protein S27 -0.03177
B2M beta-2-microglobulin -0.0314949
RPS14 ribosomal protein S14 -0.0310401
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0309224
CALR calreticulin -0.0308761
RACK1 receptor for activated C kinase 1 -0.0303322
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0301562
RPL38 ribosomal protein L38 -0.0299812
RPLP2 ribosomal protein, large, P2 -0.0298983
PTPRM protein tyrosine phosphatase, receptor type, M -0.0298407
WSB1 WD repeat and SOCS box containing 1 -0.0295699
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0293286
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0291996
RPS4X ribosomal protein S4, X-linked -0.0291084
RPS21 ribosomal protein S21 -0.0285354
KIAA0825 KIAA0825 -0.0282718
RPLP0 ribosomal protein, large, P0 -0.0281857
RPS17 ribosomal protein S17 -0.0281049
CADM2 cell adhesion molecule 2 -0.0279586
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0279421
RPS29 ribosomal protein S29 -0.0274286
S100A6 S100 calcium binding protein A6 -0.0271167
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.026912
RBM39 RNA binding motif protein 39 -0.0266865
RPS16 ribosomal protein S16 -0.0265417
RPL5 ribosomal protein L5 -0.0265153
EIF5B eukaryotic translation initiation factor 5B -0.0258694
S100A10 S100 calcium binding protein A10 -0.0258505
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0251645
SQSTM1 sequestosome 1 -0.025018
EIF3A eukaryotic translation initiation factor 3, subunit A -0.024938
PCDH15 protocadherin-related 15 -0.0244667
RPS13 ribosomal protein S13 -0.0244551
VCL vinculin -0.0244055
ANTXR1 anthrax toxin receptor 1 -0.0242932
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0240081
AGTPBP1 ATP/GTP binding protein 1 -0.0236026
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.023601
RPL27 ribosomal protein L27 -0.0234739
PCBP3 poly(rC) binding protein 3 -0.0233255
NCOA7 nuclear receptor coactivator 7 -0.0233029
EEF1G eukaryotic translation elongation factor 1 gamma -0.0232892
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0232795
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0227887
RPS25 ribosomal protein S25 -0.0226504
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0222368
PDE7B phosphodiesterase 7B -0.0221861