Cinacalcet_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cinacalcet perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

61 genes differentially expressed following the Cinacalcet_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.251316
PDE4D phosphodiesterase 4D, cAMP-specific 0.230414
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.178628
NLGN1 neuroligin 1 0.170973
FN1 fibronectin 1 0.165073
IGFBP3 insulin-like growth factor binding protein 3 0.104897
RUNX1 runt-related transcription factor 1 0.0794589
FMN1 formin 1 0.0779533
AKAP12 A kinase (PRKA) anchor protein 12 0.0731165
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0718929
CD44 CD44 molecule (Indian blood group) 0.0672848
MYOF myoferlin 0.0629447
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0586274
TRIO trio Rho guanine nucleotide exchange factor 0.0561865
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.055142
HMGA2 high mobility group AT-hook 2 0.0517114
MAML3 mastermind-like 3 (Drosophila) 0.0454672
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0450434
AKAP13 A kinase (PRKA) anchor protein 13 0.0402658
BIRC6 baculoviral IAP repeat containing 6 0.0306444
MACF1 microtubule-actin crosslinking factor 1 0.029342
ELL2 elongation factor, RNA polymerase II, 2 0.0290852
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0221867
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0219427
CARD16 caspase recruitment domain family, member 16 0.0217247
ASPH aspartate beta-hydroxylase 0.0208464
PTMA prothymosin, alpha 0.0173772
MTSS1 metastasis suppressor 1 0.00996185
FNDC3B fibronectin type III domain containing 3B 0.00906465

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.237683
NKD1 naked cuticle homolog 1 (Drosophila) -0.195563
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.189415
NAV2 neuron navigator 2 -0.179432
JMJD1C jumonji domain containing 1C -0.15668
RPS16 ribosomal protein S16 -0.148441
VIM vimentin -0.112293
FMNL2 formin-like 2 -0.105182
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0998484
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0875262
EXT1 exostosin glycosyltransferase 1 -0.0873292
ZFAND3 zinc finger, AN1-type domain 3 -0.0838427
ITGA6 integrin, alpha 6 -0.082894
SNX9 sorting nexin 9 -0.0715865
LMO7 LIM domain 7 -0.0596866
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0584848
GLIS3 GLIS family zinc finger 3 -0.056341
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0510531
DSPP dentin sialophosphoprotein -0.0421604
ACBD3 acyl-CoA binding domain containing 3 -0.0392137
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.032243
MAML2 mastermind-like 2 (Drosophila) -0.024112
IRS2 insulin receptor substrate 2 -0.0189747
USP3 ubiquitin specific peptidase 3 -0.0170554
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0167365
RPLP1 ribosomal protein, large, P1 -0.016473
SOS1 son of sevenless homolog 1 (Drosophila) -0.014923
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0110489
KMT2C lysine (K)-specific methyltransferase 2C -0.0092095
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.00783715
RPS6 ribosomal protein S6 -0.00221886
NAMPT nicotinamide phosphoribosyltransferase -0.00112925